[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.14405/kjvr.2018.58.4.183

Long-circulating and target-specific distributions of cyanine 5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days after a single administration

Yun, Tae Sik (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Lin, Chunmei (College of Chinese Medicinal Materials, Jilin Agricultural University)
Yon, Jung-Min (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Park, Seul Gi (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Gwon, Lee Wha (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Lee, Jong-Geol (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Baek, In-Jeoung (Asan Institute for Life Sciences, University of Ulsan College of Medicine)
Nahm, Sang-Seop (College of Veterinary Medicine, Konkuk University)
Lee, Beom Jun (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Yun, Young Won (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
Nam, Sang-Yoon (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)

Publication Information

Korean Journal of Veterinary Research / v.58, no.4, 2018 , pp. 183-192 More about this Journal

Abstract

Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320-400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet fully understood. After a dose of 5 mg/kg of cyanine 5.5-labeled HA-NPs or HA-polymers was intravenously administrated into mice, the fluorescence was measured from 0.5 h to 28 days. The HA-NPs fluorescence was generally stronger than that of HA-polymers, which was maintained at a high level over 7 days in vivo, after which it gradually decreased. Upon ex vivo imaging, liver, spleen, kidney, lung, testis and sublingual gland fluorescences were much higher than that of other organs. The fluorescence of HA-NPs in the liver, spleen and kidney was highest at 30 min, where it was generally maintained until 4 h, while it drastically decreased at 1 day. However, the fluorescence in the liver and spleen increased sharply at 7 days relative to 3 days, then decreased drastically at 14 days. Conversely, the fluorescence of HA-polymers in the lymph node was higher than that of HA-NPs. The results presented herein may have important clinical implications regarding the safety of as self-assembled HA-NPs, which can be widely used in biomedical applications.

Keywords

drug delivery systems; hyaluronic acid; nanoparticles; tissue distribution; toxicokinetics;

Citations & Related Records

Reference

1	Choi KY, Min KH, Na JH, Choi K, Kim K, Park JH, Kwon IC, Jeong SY. Self-Assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution. J Mater Chem 2009, 19, 4029-4280. DOI
2	Choi KY, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Choi K, Jeong SY. PEGylation of hyaluronic acid nanoparticles improves tumor target ability in vivo. Biomaterials 2011, 32, 1880-1889. DOI
3	Collins MN, Birkinshaw C. Hyaluronic acid based scaffolds for tissue engineering-a review. Carbohyd Polym 2013, 92, 1262-1279. DOI
4	Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 1996, 13, 1838-1845. DOI
5	Desai MP, Labhasetwar V, Walter E, Levy RJ, Amidon GL. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res 1997, 14, 1568-1573. DOI
6	Fraser JRE, Appelgren LE, Laurent TC. Tissue uptake of circulating hyaluronic acid: a whole body autoradiographic study. Cell Tissue Res 1983, 233, 285-293.
7	Hwang HY, Kim IS, Kwon IC, Kim YH. Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release 2008, 128, 23-31. DOI
8	Joris F, Manshian BB, Peynshaert K, De Smedt SC, Braeckmans K, Soenen SJ. Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap. Chem Soc Rev 2013, 42, 8339-8359. DOI
9	Lee H, Lee K, Kim IK, Park TG. Synthesis, characterization, and in vivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes. Biomaterials 2008, 29, 4709-4718. DOI
10	Lee JS, Ji HJ, Chai H, Jeong JH, Nam SY, Yun YW, Lee BJ. Distribution and accumulation of Cy5.5-labeled hydrophobically modified glycol chitosan in mice. J Prev Vet Med 2015, 39, 48-57.
11	Marquis BJ, Love SA, Braun KL, Haynes CL. Analytical methods to assess nanoparticle toxicity. Analyst 2009, 134, 425-439. DOI
12	Mironov V, Kasyano V, Shu XZ, Eisenberg C, Eisenberg L, Gonda S, Trusk T, Markwald RR, Prestwich GD. Fabrication of tubular tissue constructs by centrifugal casting of cells suspended in an in situ crosslinkable hyaluronangelatin hydrogel. Biomaterials 2005, 26, 7628-7635. DOI
13	Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001, 53, 283-318.
14	Nam JM, Thaxton CS, Mirkin CA. Nanoparticle-based biobar codes for the ultrasensitive detection of proteins. Science 2003, 301, 1884-1886. DOI
15	Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003, 55, 329-347. DOI
16	Teijeiro C, McGlone A, Csaba N, Garcia-Fuentes M, Alonso MJ. Polysaccharide-based nanocarriers for drug delivery. In: Torchilin V (ed.). Handbook of Nanobiomedical Research: Fundamentals, Applications and Recent Developments. Vol. 1. 1st ed. pp. 235-278, World Scientific, Singapore, 2014.
17	Rosler A, Vandermeulen GWM, Klok HA. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv Drug Deliv Rev 2001, 53, 95-108. DOI
18	Song U, Jun H, Waldman B, Roh J, Kim Y, Yi J, Lee EJ. Functional analyses of nanoparticle toxicity: a comparative study of the effects of TiO2 and Ag on tomatoes (Lycopersicon esculentum). Ecotoxicol Environ Saf 2013, 93, 60-67. DOI
19	Taton TA, Mirkin CA, Letsinger RL. Scanometric DNA array detection with nanoparticle probes. Science 2000, 289, 1757-1760. DOI
20	Thomas SN, Schudel A. Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery. Curr Opin Chem Eng 2015, 7, 65-74. DOI
21	Tiantian Y, Wenji Z, Mingshuang S, Rui Y, Shuangshuang S, Yuling M, Jianhua Y, Xinggang Y, Shujun W, Weisan P. Study on intralymphatic-targeted hyaluronic acid-modified nanoliposome: influence of formulation factors on the lymphatic targeting. Int J Pharm 2014, 471, 245-257. DOI
22	Tripodo G, Trapani A, Torre ML, Giammona G, Trapani G, Mandracchia D. Hyaluronic acid and its derivatives in drug delivery and imaging: recent advances and challenges. Eur J Pharm Biopharm 2015, 97, 400-416. DOI
23	Walkey CD, Olsen JB, Guo H, Emili A, Chan WCW. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc 2012, 134, 2139-2147. DOI
24	Choi KY, Chung H, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Jeong SY. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 2010, 31, 106-114. DOI
25	Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mdler L, Cohen Y, Zink JI, Nel AE. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 2012, 6, 4349-4368. DOI
26	Arpicco S, Milla P, Stella B, Dosio F. Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment. Molecules 2014, 19, 3193-3230. DOI
27	Battistini FD, Olivera ME, Manzo RH. Equilibrium and release properties of hyaluronic acid-drug complexes. Eur J Pharm Sci 2013, 49, 588-594. DOI