Browse > Article
http://dx.doi.org/10.14405/kjvr.2014.54.4.245

Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats  

Hue, Jin Joo (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
Lee, Hu-Jang (College of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University)
Jon, Sangyong (School of Life Science, Gwangju Institute of Science and Technology)
Nam, Sang Yoon (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
Yun, Young Won (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
Kim, Jong-Soo (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
Lee, Beom Jun (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
Publication Information
Korean Journal of Veterinary Research / v.54, no.4, 2014 , pp. 245-252 More about this Journal
Abstract
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-${\alpha}$ and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
Keywords
accumulation; biodistribution; rats; thermally cross-linked superparamagnetic iron oxide nanoparticles; toxicity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Arbab AS, Ichikawa T, Sou H, Araki T, Nakajima H, Ishigame K, Yoshikawa T, Kumagai H. Ferumoxides-enhanced double-echo T2-weighted MR imaging in differentiating metastases from nonsolid benign lesions of the liver. Radiology 2002, 225, 151-158.   DOI
2 Baldi G, Bonacchi D, Franchini MC, Gentili D, Lorenzi G, Ricci A, Ravagli C. Synthesis and coating of cobalt ferrite nanoparticles: a first step toward the obtainment of new magnetic nanocarriers. Langmuir 2007, 23, 4026-4028.   DOI
3 Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS. Noninvasive imaging of quantum dots in mice. Bioconjug Chem 2004, 15, 79-86.   DOI   ScienceOn
4 Berry CC. Progress in functionalization of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2009, 42, 224003.   DOI   ScienceOn
5 Bourrinet P, Bengele HH, Bonnemain B, Dencausse A, Idee JM, Jacobs PM, Lewis JM. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol 2006, 41, 313-324.   DOI   ScienceOn
6 Goya GF, Grazu V, Ibarra MR. Magnetic nanoparticles for cancer therapy. Curr Nanosci 2008, 4, 1-6.   DOI
7 Briley-Saebo KC, Johansson LO, Hustvedt SO, Haldorsen AG, Bjornerud A, Fayad ZA, Ahlstrom HK. Clearance of iron oxide particles in rat liver effect of hydrated particle size and coating material on liver metabolism. Invest Radiol 2006, 41, 560-570.   DOI   ScienceOn
8 Chertok B, Moffat BA, David AE, Yu F, Bergemann C, Ross BD, Yang VC. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 2008, 29, 487-496.   DOI   ScienceOn
9 Crichton RR, Wilmet S, Legssyer R, Ward RJ. Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem 2002, 91, 9-18.   DOI
10 Gupta AK, Curtis AS. Surface modified superparamagnetic nanoparticles for drug delivery: interaction studies with human fibroblasts in culture. J Mater Sci Mater Med 2004, 15, 493-496.   DOI   ScienceOn
11 Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003, 348, 2491-2499.   DOI   ScienceOn
12 Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm 2008, 5, 316-327.   DOI
13 Lee H, Yu MK, Park S, Moon S, Min JJ, Jeong YY, Kang HW, Jon S. Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo. J Am Chem Soc 2007, 129, 12739-12745.   DOI   ScienceOn
14 Kim JH, Hue JJ, Kang BS, Park H, Nam SY, Yun YW, Kim JS, Lee BJ. Effects of selenium on colon carcinogenesis induced by azoxymethane and dextran sodium sulfate in mouse model with high-iron diet. Lab Anim Res 2011, 27, 9-18.   DOI
15 Kohler N, Sun C, Wang J, Zhang M. Methotrexatemodified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir 2005, 21, 8858-8864.   DOI   ScienceOn
16 Kolb AM, Smit NPM, Lentz-Ljuboje R, Osanto S, van Pelt J. Non-transferrin bound iron measurement is influenced by chelator concentration. Anal Biochem 2009, 385, 13-19.   DOI
17 Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 2000, 18, 410-414.   DOI   ScienceOn
18 Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2010, 469, 6-10.   DOI   ScienceOn
19 Sajiki J, Iwata H, Paek HJ, Tosha T, Fujita S, Ueda Y, Park YG, Zhu B, Satoh S, Ikai I, Yamaoka Y, Ikada Y. Transmission electron microscopic study of hepatocytes in bioartificial liver. Tissue Eng 2000, 6, 627-640.   DOI
20 Sarin H. Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. J Angiogenes Res 2010, 2, 14.   DOI
21 Sun C, Lee JSH, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 2008, 60, 1252-1265.   DOI   ScienceOn
22 Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, Koretsky AP. MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A 2004, 101, 10901-10906.   DOI
23 Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A 2006, 103, 3357-3362.   DOI
24 Tartaj P, Morales MDP, Veintemillas-Verdaguer S, Gonzalez-Carreno T, Serna CJ. The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2003, 36, R182-197.   DOI   ScienceOn
25 Rana S, Gallo A, Srivastava RS, Misra RDK. On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics. Acta Biomater 2007, 3, 233-242.   DOI   ScienceOn
26 Riggio C, Calatayud MP, Hoskins C, Pinkernelle J, Sanz B, Torres TE, Ibarra MR, Wang L, Keilhoff G, Goya GF, Raffa V, Cuschieri A. Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance. Int J Nanomedicine 2012, 7, 3155-3166.
27 Thorek DLJ, Chen AK, Czupryna J, Tsourkas A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng 2006, 34, 23-38.   DOI   ScienceOn
28 Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. Heme and iron metabolism: Role in cerebral hemorrhage. J Cereb Blood Flow Metab 2003, 23, 629-652.   DOI
29 Wang YX, Hussain SM, Krestin GP. Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging. Eur Radiol 2001, 11, 2319-2331.   DOI   ScienceOn
30 Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab 2010, 30, 15-35.   DOI
31 Willard MA, Kurihara LK, Carpenter EE, Calvin S, Harris VG. Chemically prepared magnetic nanoparticles. Int Mater Rev 2004, 49, 125-170.   DOI   ScienceOn
32 Meyrick D, Webb J, Cole C. Iron and iron proteins found in the genetic disease, hereditary spherocytosis. Inorganica Chim Acta 2002, 339, 481-487.   DOI
33 Zhang P, Sawicki V, Lewis A, Hanson L, Monks J, Neville MC. The effect of serum iron concentration on iron secretion into mouse milk. J Physiol 2000, 522, 479-491.   DOI