[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.14405/kjvr.2014.54.1.21

Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus

Chung, Kang Min (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)
Kang, Wonyoung (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)
Kim, Dong Geon (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)
Hong, Hyun Ju (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)
Lee, Youngjae (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)
Han, Chang-Hoon (Department of Toxicology and Biochemistry, College of Veterinary Medicine, Jeju National University)

Publication Information

Korean Journal of Veterinary Research / v.54, no.1, 2014 , pp. 21-26 More about this Journal

Abstract

Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated the effects of benfotiamine on the hepatic insulin signaling pathway in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are a type 2 diabetes mellitus model. OLETF rats treated with benfotiamine showed decreased body weight gain and reduced adipose tissue weight. In addition, blood glucose levels were lower in OLETF rats treated with benfotiamine. Following treatment with benfotiamine, the levels of Akt phosphorylation (S473/T308) in the OLETF groups increased significantly compared to the OLETF control group so that they were almost identical to the levels observed in the control group. Moreover, benfotiamine restored the phosphorylation levels of both glycogen synthase kinase (GSK)- $3{\alpha}/{\beta}$ (S21, S9) and glycogen synthase (GS; S641) in OLETF rats to nearly the same levels observed in the control group. Overall, these results suggest that benfotiamine can potentially attenuate type 2 diabetes mellitus in OLETF rats by restoring insulin sensitivity through upregulation of Akt phosphorylation and activation of two downstream signaling molecules, GSK- $3{\alpha}/{\beta}$ and GS, thereby reducing blood glucose levels through glycogen synthesis.

Keywords

Akt phosphorylation; benfotiamine; insulin signaling pathway; OLETF rats; type 2 diabetes mellitus;

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Times Cited By KSCI : 1 (Citation Analysis)

Reference
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1664-042X	(2018) Frontiers in Physiology Benfotiamine, a Lipid-Soluble Analog of Vitamin B1, Improves the Mitochondrial Biogenesis and Function in Blunt Snout Bream (Megalobrama amblycephala) Fed High-Carbohydrate Diets by Promoting the AMPK/PGC-1β/NRF-1 Axis / 9 (1664-042X)