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Discoid lupus erythematosus (DLE) in a juvenile Alaskan Malamute dog  

Kim, Ha-Jung (College of Veterinary Medicine, Konkuk University)
Yoo, Jong-Hyun (College of Veterinary Medicine, Konkuk University)
Kim, Ju-Won (College of Veterinary Medicine, Konkuk University)
Park, Chul (School of Veterinary Medicine, University of California)
Lim, Chae-Young (College of Veterinary Medicine, Konkuk University)
Lee, Jong-Hwan (College of Veterinary Medicine, Konkuk University)
Quan, Fu-Shi (College of Medicine, The Catholic University of Korea)
Park, Hee-Myung (College of Veterinary Medicine, Konkuk University)
Publication Information
Korean Journal of Veterinary Research / v.49, no.1, 2009 , pp. 73-78 More about this Journal
Abstract
Discoid lupus erythematosus (DLE) is an immune-mediated skin disease which requires histopathology and immunohistopathology in both dogs and humans. A 10-month-old, intact female Alaskan Malamute presented for depigmentation, swelling, alopecia, erythema, and crusting on the bridge of the nose and the nasal planum. Cytological examination of nasal lesions revealed numerous cocci and neutrophils. Histopathological features included of infiltration of mononuclear cells at the dermoepidermal junction. Direct immunofluorescence tests and immunohistochemistry exhibited positive IgG, IgM, IgA, CD3, CD18, and CD79a on the epidermal basement membranes and around adnexal glands. This case indicates both T cells and B cells are related to mechanism of canine DLE. This case report describes advanced diagnostic tests and clinical outcome with immune suppressive therapy in a rare juvenile canine DLE case.
Keywords
discoid lupus erythematosus; dog; immunohistochemistry; immunohistopathology;
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