Browse > Article

Ovarian adenocarcinoma in white leghorn and Ogol chicken  

Ha, Jeong-Im (College of Veterinary Medicine, Seoul National University)
Jee, Hyang (College of Veterinary Medicine, Seoul National University)
Lim, Jung-Mook (College of Agricultural Biotechnology, Seoul National University)
Han, Jae-Yong (College of Agricultural Biotechnology, Seoul National University)
Kim, Dae-Yong (College of Veterinary Medicine, Seoul National University)
Publication Information
Korean Journal of Veterinary Research / v.48, no.4, 2008 , pp. 469-472 More about this Journal
Abstract
Necropsy was performed on a total of twenty three either white leghorn or ogol chickens which were more than 150 weeks of age. Among twenty three chickens examined, fifteen chickens were laying and the rest eight chickens were non-laying. On necropsy, neoplastic mass in the five chickens among non-laying chickens was found. These neoplastic masses were present mostly in the ovaries and one case in the liver and characterized by multifocal to coalescing 1 to 5 mm tan firm nodular formation. On histopathology, ovarian adenocarcinoma with widespread abdominal seeding and hepatic metastasis was diagnosed in the three chickens. Oviductal leiomyoma was also found in two chickens that had a focal well-demarcated nodules in the oviduct. Taken together, the number with ovarian adenocarcinoma among non-laying chickens over 150 week old was 37.5%. As most animal species do rarely develop ovarian tumors, the high rate of spontaneous ovarian adenocarcinoma in non-laying hen suggest that the hen is a proper model for human ovarian cancer study.
Keywords
chicken; neoplasia; ovarian adenocarcinoma; oviductal leiomyoma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chi DS, Hoskins WJ. Primary surgical management of ovarian cancer. In: Bartlett JMS (ed.). Ovarian Cancer: Methods and Protocols. Vol. 39. pp. 75-87, Humana Press, Totowa, 2000
2 Rodriguez-Burford C, Barnes MN, Berry W, Partridge EE, Grizzle WE. Immunohistochemical expression of molecular markers in an avian model: a potential model for preclinical evaluation of agents for ovarian cancer chemoprevention. Gynecol Oncol 2001, 81, 373-379   DOI   ScienceOn
3 Johnson PA, Giles JR. Use of genetic strains of chickens in studies of ovarian cancer. Poult Sci 2006, 85, 246-250   DOI
4 Urick ME, Johnson PA. Cyclooxygenase 1 and 2 mRNA and protein expression in the Gallus domesticus model of ovarian cancer. Gynecol Oncol 2006, 103, 673-678   DOI   ScienceOn
5 Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55, 74-108   DOI   ScienceOn
6 Giles JR, Shivaprasad HL, Johnson PA. Ovarian tumor expression of an oviductal protein in the hen: a model for human serous ovarian adenocarcinoma. Gynecol Oncol 2004, 95, 530-533   DOI   ScienceOn
7 Alfonso M, Adochiles L, Hendrickson VM, Carver DK, Rodriguez GC, Barnes HJ. Metastatic adenocarcinoma in the lungs of older laying hens. Avain Dis 2005, 49, 430-432   DOI   ScienceOn
8 Jackson E, Anderson K, Ashwell C, Petitte J, Mozdziak PE. CA125 expression in spontaneous ovarian adenocarcinomas from laying hens. Gynecol Oncol 2007, 104, 192-198   DOI   ScienceOn
9 Auersperg N, Maines-Bandiera SL. Culture and characterization of human ovarian surface epithelium. In: Bartlett JMS (ed.). Ovarian Cancer: Methods and Protocols. Vol. 39. pp. 169-174, Humana Press, Totowa, 2000
10 Barnes MN, Berry WD, Straughn JMJ, Kirby TO, Leath CA, Huh WK, Grizzle WE, Partridge EE. A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis. Gynecol Oncol 2002, 87, 57-63   DOI   ScienceOn
11 Fredrickson TN. Ovarian tumors of the hen. Environ Health Perspect 1987, 73, 35-51   DOI