Browse > Article

Effects of 2,3',4,4',5-pentachlorobiphenyl (PCB#118) on morphological changes in the rat testis  

Kim, Gon-Sup (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Park, Oh-Sung (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Han, Dae-Yong (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Kim, Mun-Ki (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Koh, Phil-Ok (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Cho, Jae-Hyeon (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Kim, Soon-Bok (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Won, Chung-Kil (Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Korean Journal of Veterinary Research / v.48, no.4, 2008 , pp. 385-391 More about this Journal
Abstract
This study was performed to examine the effect of 2,3',4,4',5-pentachlorobiphenyl (PCB#118) on testis of male rats. PCB#118 (20 mg/kg/week) in corn oil was intraperitoneally injected to adult male rats for 2, 5, 8 weeks. The body and testicular weights were measured at 3, 6, 9 weeks of PCB treatment. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results showed that PCB#118 caused significant change in the body weights and testicular weights. Moreover, the morphological studies that were conducted on the PCB-treated rats revealed that the number of spermatocytes and spermatids in their seminiferous tubules decreased than control group (LM). The nuclear membrane was damaged when PCB was administered to them for 9 weeks (TEM). These results suggest that the reproductive function of the adult male rats is sensitive to PCB#118, and that may affect the testicular morphology of adult male rats.
Keywords
morphology; polychlorinated biphenyl; testis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Backlin BM, Bergman A. Histopathology of postpartum placental sites in mink (Mustela vison) exposed to polychlorinated biphenyls or fractions thereof. APMIS 1995, 103, 843-854   DOI   ScienceOn
2 Spearow JL, Doemeny P, Sera R, Leffler R, Barkley M. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Science 1999, 285, 1259-1261   DOI   ScienceOn
3 Yamamoto M, Shirai M, Tamura A, Kobayashi T, Kohara S, Murakami M, Arishima K. Effects of maternal exposure to a low dose of diethylstilbestrol on sexual dimorphic nucleus volume and male reproductive system in rat offspring. J Toxicol Sci 2005, 30, 7-18   DOI   ScienceOn
4 Mably TA, Moore RW, Peterson RE. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Effects on androgenic status. Toxicol Appl Pharmacol 1992, 114, 97-107   DOI   ScienceOn
5 Kovacevi R, Vojinovi -Miloradov M, Teodorovi I, Andri S. Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro. J Steroid Biochem Mol Biol 1995, 52, 595-597   DOI   ScienceOn
6 Foster PM, Harris MW. Changes in androgenmediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages. Toxicol Sci 2005, 85, 1024-1032   DOI   ScienceOn
7 Ahmad N, Haltmeyer GC, Eik-Nes KB. Maintenance of spermatogenesis in rats with intratesticular implants containing testosterone or dihydrotestosterone (DHT). Biol Reprod 1973, 8, 411-419   DOI
8 Mclachlan JA, Newbold RR, Li S, Negishi M. Are estrogens carcinogenic during development of the testes? APMIS 1998, 106, 240-242   DOI   ScienceOn
9 Takao T, Nanamiya W, Nagano I, Asaba K, Kawabata K, Hashimoto K. Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice. Life Sci 1999, 65, 2351-2357   DOI   ScienceOn
10 Goldman D, Yawetz A. The interference of polychlorinated biphenyls (Aroclor 1254) with membrane regulation of the activities of cytochromes P-450C21 and P-450(17) alpha,lyase in guinea-pig adrenal microsomes. J Steroid Biochem Mol Biol 1992, 42, 37-47   DOI   ScienceOn
11 Wilker C, Johnson L, Safe S. Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. Toxicol Appl Pharmacol 1996, 141, 68-75   DOI
12 Kim Y, Park J, Moon Y. Hematopoietic and reproductive toxicity of 2-bromopropane, a recently introduced substitute for chlorofluorocarbons. Toxicol Lett 1999, 108, 309-313   DOI   ScienceOn
13 Hagenas L, Ritzen EM, Plooen L, Hansson V, French FS, Nayfeh SN. Sertoli cell origin of testicular androgen-binding protein (ABP). Mol Cell Endocrinol 1975, 2, 339-350   DOI   ScienceOn
14 Faqi AS, Dalsenter PR, Merker HJ, Chahoud I. Effects on developmental landmarks and reproductive capability of 3,3',4,4'-tetrachlorobiphenyl and 3,3',4,4',5-pentachlorobiphenyl in offspring of rats exposed during pregnancy. Hum Exp Toxicol 1998, 17, 365-372   DOI   ScienceOn
15 Hess RA, Bunick D, Lee KH, Bahr J, Taylor JA, Korach KS, Lubahn DB. A role for oestrogens in the male reproductive system. Nature 1997, 390, 509-512   DOI   ScienceOn
16 Mably TA, Moore RW, Goy RW, Peterson RE. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood. Toxicol Appl Pharmacol 1992, 114, 108-117   DOI   ScienceOn
17 Pflieger-Bruss S, Hanf V, Behnisch P, Hagenmaier H, Rune GM. Effects of single polychlorinated biphenyls on the morphology of cultured rat tubuli seminiferi. Andrologia 1999, 31, 77-82   DOI
18 Sager DB. Effect of postnatal exposure to polychlorinated biphenyls on adult male reproductive function. Environ Res 1983, 31, 76-94   DOI   ScienceOn
19 Shain W, Overmann SR, Wilson LR, Kostas J, Bush B. A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure. Arch Environ Contam Toxicol 1986, 15, 687-707   DOI
20 Van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, van Leeuwen FX, Liem AK, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998, 106, 775-792   DOI
21 Won CK, Park OS, Han DY, Koh PO, Cho JH, Kim EH, Kim GS. Effect of 2,3,3',4,4'-pentachlorobiphenyl (PCB#105) on rat testes. Lab Anim Res 2007, 23, 333-337
22 Yu WJ, Lee BJ, Nam SY, Ahn B, Hong JT, Do JC, Kim YC, Lee YS, Yun YW. Reproductive disorders in pubertal and adult phase of the male rats exposed to vinclozolin during puberty. J Vet Med Sci 2004, 66, 847-853   DOI   ScienceOn
23 Takagi Y, Aburada S, Hashimoto K, Kitaura T. Transfer and distribution of accumulated (14C) polychlorinated biphenyls from maternal to fetal and suckling rats. Arch Environ Contam Toxicol 1986, 15, 709-715   DOI
24 Brezner E, Terkel J, Perry AS. The effect of Aroclor 1254 (PCB) on the physiology of reproduction in the female rat-I. Comp Biochem Physiol C 1984, 77, 65-70   DOI   ScienceOn
25 Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 1993, 101, 378-384   DOI
26 Pocar P, Klonisch T, Brandsch C, Eder K, Frhlich C, Hoang-Vu C, Hombach-Klonisch S. AhR-agonistinduced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes. Toxicol Sci 2006, 89, 408-414   DOI   ScienceOn
27 Gray LE, Ostby JS, Kelce WR. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring. Toxicol Appl Pharmacol 1997, 146, 11-20   DOI   ScienceOn
28 Rowlands JC, Gustafsson JA. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997, 27, 109-134   DOI
29 Safe S. Polychlorinated biphenyls (PCBs), dibenzo-pdioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 1990, 21, 51-88   DOI
30 Roman BL, Timms BG, Prins GS, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development. 2. Effects on growth and cytodifferentiation. Toxicol Appl Pharmacol 1998, 150, 254-270   DOI   ScienceOn
31 Sager DB, Shih-Schroeder W, Girard D. Effect of early postnatal exposure to polychlorinated biphenyls (PCBs) on fertility in male rats. Bull Environ Contam Toxicol 1987, 38, 946-953   DOI
32 Crisp TM, Clegg ED, Cooper RL, Wood WP, Anderson DG, Baetcke KP, Hoffmann JL, Morrow MS, Rodier DJ, Schaeffer JE, Touart LW, Zeeman MG, Patel YM. Environmental endocrine disruption: an effects assessment and analysis. Environ Health Perspect 1998, 106, 11-56   DOI
33 Myllymaki SA, Haavisto TE, Brokken LJ, Viluksela M, Toppari J, Paranko J. In utero and lactational exposure to TCDD; steroidogenic outcomes differ in male and female rat pups. Toxicol Sci 2005 88, 534-544   DOI   ScienceOn