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Medical imaging and immunohistochemical diagnosis of gastrointestinal stromal tumor originated from colon in a dog  

Choi, Jihye (Haemaru Referral Animal Hospital)
Kim, Hyunwook (Haemaru Referral Animal Hospital)
Lee, Haekyung (Haemaru Referral Animal Hospital)
Kim, Junyoung (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
Yoon, Junghee (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
Publication Information
Korean Journal of Veterinary Research / v.48, no.1, 2008 , pp. 111-117 More about this Journal
Abstract
Gastrointestinal stromal tumor (GIST) is one of the mesenchymal tumors originated from gastrointestinal submucosa. A 10 year-old, male, mixed breed dog with persistent diarrhea, anorexia and lethargy was referred to Haemaru Animal Referral Hospital. Large mass originated from the transverse colon was observed and large amount of ascites and free gas were found on abdominal radiography and ultrasonography. The ascites was septic exudate mixed with bacteria that consisted with intestinal perforation. There was no metastatic lesion. This mass was tentatively diagnosed as adenocarcinoma, leiomyosarcoma (LMS) and lymphosarcoma and surgical resection and histilogical examination were planned. However, according to owner's request, the patient was euthanized and then the necropsy was performed. About 10 cm sized mass originated from the cecum, ascending colon and transverse colon was adhered to surrounding mesentery and the perforation and large amount of ascites were observed. GIST was suspected on histopathologic examination and confirmed according to CD 117 expression in immunohistochemistry. GIST, derived from interstitial cells of Cajal, can be distinguished from LMS and leiomyoma (LM) on the basis of expression of CD117 (KIT) immunohistochemically. GIST has a different biological behavior and clinical course compared with LMS and LM, therefore definite diagnosis for GIST using immunohistochemistry is clinically important to predict the precise prognosis of the patient.
Keywords
dog; gastrointestinal stromal tumor; mesenchymal; immunohistochemistry; CD117;
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1 Koh JS, Trent J, Chen L, El-Naggar A, Hunt K, Pollock R, Zhang W. Gastrointestinal stromal tumors: overview of pathologic features, molecular biology, and therapy with imatinib mesylate. Histol Histopathol 2004, 19, 565-574
2 LaRock RG, Ginn PE. Immunohistochemical staining characteristics of canine gastrointestinal stromal tumors. Vet Pathol 1997, 34, 303-311   DOI   ScienceOn
3 Withrow JS. Gastric cancer. In: Withrow JS, MacEwin EG (eds.). Withrow and MacEwen's Small Animal Clinical Oncology. 4th ed. pp. 480-491, Saunders, Philadelphia, 2007
4 Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol 2003, 54, 3-24
5 Frost D, Lasota J, Miettinen M. Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 2003, 40, 42-54   DOI   ScienceOn
6 Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol 1999, 30, 1213-1220   DOI   ScienceOn
7 Kumagai K, Uchida K, Miyamoto T, Ushigusa T, Shinohara S, Yamaguchi R, Tateyama S. Three cases of canine gastrointestinal stromal tumors with multiple differentiations and c-kit-expression. J Vet Med Sci 2003, 65, 1119-1122   DOI   ScienceOn
8 Bettini G, Morini M, Marcato PS. Gastrointestinal spindle cell tumours of the dog: histological and immunohistochemical study. J Comp Pathol 2003, 129, 283-293   DOI   ScienceOn
9 Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002, 33, 459-465   DOI   ScienceOn
10 강동욱, 김주헌, 김동훈, 김경희, 박미자, 강대영. 위장관 간질종양에서 c-kit 유전자 돌연변이 및 면역조직화학적 발현. 대한병리학회지 2003, 37, 246-254
11 Russell KN, Mehler SJ, Skorupski KA, Baez JL, Shofer FS, Goldschmidt MH. Clinical and immunohistochemical differentiation of gastrointestinal stromal tumors from leiomyosarcomas in dogs: 42 cases (1990-2003). J Am Vet Med Assoc 2007, 230, 1329-1333   DOI   ScienceOn
12 Cohen M, Post GS, Wright JC. Gastrointestinal Leiomyosarcoma in 14 Dogs. J Vet Intern Med 2003, 17, 107-110   DOI   ScienceOn
13 Maas CPHJ, Haar GT, van der Gaag I, Kirpensteijn J. Reclassification of small intestinal and cecal smooth muscle tumors in 72 dogs: clinical, histologic, and immunohistochemical evaluation. Vet Surg 2007, 36, 302-313   DOI   ScienceOn
14 Selting KA. Tumors of the intestinal tract. In: Withrow SJ, MacEwin EG (eds.). Withrow and MacEwen's Small Animal Clinical Oncology. 4th ed. pp. 491-501, Saunders, Philadelphia, 2007
15 Lennartsson J, Ronnstrand L. The stem cell factor receptor/c-KIT as a drug target in cancer. Curr Cancer Drug Targets 2006, 6, 65-75   DOI   ScienceOn