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Effect of lithium on endothelial-dependent relaxation to melatonin in rat aorta  

Kim, Shang-Jin (Bio-Safety Research Institute, Chonbuk National University)
Yu, Xianfeng (Bio-Safety Research Institute, Chonbuk National University)
Cho, In-Gook (Bio-Safety Research Institute, Chonbuk National University)
Kang, Hyung-Sub (Bio-Safety Research Institute, Chonbuk National University)
Kim, Jin-Shang (Bio-Safety Research Institute, Chonbuk National University)
Publication Information
Korean Journal of Veterinary Research / v.45, no.4, 2005 , pp. 553-562 More about this Journal
Abstract
Melatonin, the principal hormone of the vertebral pineal gland, participates in the regulation of cardiovascular system in vitro and in vivo. Lithium inhibits both inositol polyphosphate phosphatase (IPPase) and inositol monophosphatase (IMPase), which are involved in a wide range of signal transduction pathways. The aim of the present study was to assess the effect of lithium on endothelial-dependent relaxation to melatonin and on the melatonin-induced inhibition of contraction by phenylephrine (PE) in isolated rat aorta. Melatonin induced a concentration-dependent relaxation in PE-precontracted in endothelium-intact (+E) aortic rings. Melatonin inhibited a PE-induced sustained contraction in +E aortic rings. These effects of melatonin on relaxation and contractile responses were inhibited by pretreatment with lithium. In PE-precontracted +E aortic rings, the melatonin-induced vasorelaxations and the inhibitory effects of melatonin on maximal contractions were inhibited by endothelium removal or by pretreatment with L-$N^G$-nitro-arginine (L-NNA), 1H-[1,2,4] oxadiazolo-[4,3-a] quinoxalin-1-one (ODQ) and nifedipine and verapamil, but not by tetrabutylammonium, clotrimazole and glibenclamide, However, in endothelium-denuded (-E) aortic rings and in the presence of L-NNA and ODQ in +E aortic rings, the melatonin-induced residual relaxations and the melatonin-induced residual contractile responses to PE were not affected by lithium. It is concluded that the inositol phosphate pathway may be involved in endothelial-dependent relaxation induced by melatonin.
Keywords
aorta; contractile response; endothelium; lithium; melatonin; vasorelaxation;
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