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Histopathological classification of the bovine lymphoma caused by bovine leukemia virus in Korea  

Yoon, Soon-Seek (National Veterinary Research and Quarantine Service)
Lee, Kyeong-Hyun (National Veterinary Research and Quarantine Service)
Bae, You-Chan (National Veterinary Research and Quarantine Service)
Jean, Young-Hwa (National Veterinary Research and Quarantine Service)
Kang, Mun-Il (National Veterinary Research and Quarantine Service)
Lee, O-Soo (National Veterinary Research and Quarantine Service)
Han, Hong-Ryul (College of Veterinary Medicine, Seoul National University)
Publication Information
Korean Journal of Veterinary Research / v.45, no.3, 2005 , pp. 391-398 More about this Journal
Abstract
Several studies have been performed on the bovine leukemia since bovine leukemia virus (BLV) had been detected in 1982 in Korea. We have conducted histopathological study on the bovine lymphoma caused by BLV because only limited results were reported on the pathological characterization of lymphoma. Lymphoma tissues were obtained from cattle necropsied and slaughtered during a designated period. Lymphoma was classified histopathologically according to the National Cancer Institute Working Formulation. Leukotic tissues consisted of fairly uniform sheets of closely packed medium to large lymphocytes without any architectural arrangement in all 30 cases. Twenty five cases belong to diffuse large cell type, while three cases were diffuse mixed cell type, and two cases were immunoblastic large cell type among 30 cases. Follicular type lymphoma was not detected in this study. The mitotic index of tumor cells showed average 2.5 in the field of 400X. Nuclear cleavage was detected in 53% of cases. Multi-nucleated cells were detected among tumor cells in 30% of lymphoma cases. In conclusion, the most common morphologic cell type of bovine lymphoma in Korea was a diffuse large cell type with multinucleated cells and nuclear cleavages.
Keywords
bovine; leukemia; lymphoma; pathology;
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1 Lee BH, Kim SK, Ko KD. Epizootiological observation on bovine enzootic leukosis occurring naturally in Korea. J Korean Vet Med Ass 1977, 13, 9-16
2 Lukes RJ, Collins RD. Immunologic characterization of human malignant lymphomas. Cancer 1974, 34, 1488-1503   DOI   PUBMED   ScienceOn
3 Marshak RR, Coriell LL, Lawrence WC, Croshaw JE, Schryver HF, Altera KP, Nichols WW. Studies on bovine lymphosarcoma. I. Clinical aspects, pathological alteration, and herd studies. Cancer Res 1962, 22, 202-217
4 Renstrom LMH, Venebles C, Beier D. Manual of diagnostic tests and vaccines for terrestrial animals (Enzootic bovine leukosis). 4th ed. pp. 371-380, Office International Des Epizooties, 2004
5 Yoon SS, Park JW, Byun JW, Kang MI, Yoo HS, Han HR. Cultivation and electronmicroscopy of bovine leukemia virus from peripheral blood lymphocytes of Holstein-Friesian dairy cattle. Korean J Electron Microscopy 2005, 35, 23-30
6 Gerard-Marchant, Hamlin I, Lennert K, Rilke F, Stansfeld AG, Unnik JAMV. Classification of non-Hodgkin's lymphomas. Lancet 1974, 17, 406-408
7 Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML. A revised European-American classification of lymphoid neoplasm: A proposal from the international lymphoma study group. Blood 1994, 84, 1361-1392
8 Miller JM, Miller LD, Olson C, Gillette KG. Viruslike particle in phytohemagglutinin-stimulated lymphocyte cultures with reference to bovine lymphosarcoma. J Natl Cancer Inst 1969, 43, 1297-1305
9 Smith HA. The pathology of malignant lymphoma in cattle. A study of 1113 cases. Pathol Vet 1965, 2, 68-94
10 Brandly P, Migaki G. Types of tumors found by federal meat inspectors in eight year survey. Ann NY Acad Sci 1963, 108, 872-879   DOI   ScienceOn
11 Johnson R, Kaneene JB. Bovine leukemia virus and enzootic bovine leukosis. Vet Bulletin 1992, 62, 287-312
12 Valli VE, McSherry BJ, Dunham BM, Jacobs RM, Lumden JH. Histopathology of lymphoid tumors in the dog, cat and cow. Vet Pathol 1981, 18, 494-512   DOI
13 Maruyama K, Fukushima T, Mochizuki S. Crossreactive antibodies to BLV and HTLV in bovine and human hosts with retrovirus infection. Vet Immunol Immunpathol 1989, 22, 265-274   DOI   ScienceOn
14 Rosenberg SA, Berard CW, Brown BW, Burke J, Dorfman RF, Glatstein E, Hoppe RT, Simon R. National cancer institute sponsored study of classifications of non-Hodgkin's lymphomas. Summary and description of a working formulation for clinical usage. Cancer 1982, 49, 2112-2135   DOI   PUBMED   ScienceOn
15 Suh GH. Establishment of a bovine leukemia virus-free dairy cattle. Ph.D. Thesis, Cheonnam national university, Gwangju, Korea. 2004
16 Aida Y, Amanuma H, Okada K. Identification of tumor-associated antigen that is expressed on bovine leukemia virus-induced lymphosarcoma cells and expression of its human homologue in human T-cell lymphotrophic virus I-infected cell lines. Leukemia 1994, 8(S), 231-234
17 Lim CH. Pathologic studies of tumors occurring in cattle. Seoul Natl Univ J (C) 1969, 20, 80-88
18 Yoon SS, Bae YC, Lee KH, Han B, Han HR. Characteristics of bovine lymphoma caused by bovine leukemia virus infection in Holstein-Friesian dairy cattle in Korea. Asian-Aust J Anim Sci 2005, 18, 728-733   DOI
19 Rappaport H, Winter WJ, Hicks EB. Follicular lymphoma. A re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer 1956, 9, 792-821   DOI   PUBMED   ScienceOn
20 Burny A, Bex F, Chantrenne H, Cleute Y, Dekegel D, Ghysdael J, Kettmann R, Leclercq M, Leunen J, Mammerickx M, Portetelle D. Bovine leukemia virus involvement in enzootic bovine leukosis. Advance Can Res 1978, 28, 251-311   DOI
21 Vernau W, Valli VEO, Dukes TW, Jacobs RM, Shoukri M, Heeney JL. Classification of 1,198 cases of bovine lymphoma using the national cancer institute working formulation for human non-Hodgkin's lymphoma. Vet Pathol 1992, 29, 183-195   DOI   ScienceOn
22 Trainin Z, Brenner J, Meirom R, Ungar-Waron H. Detrimental effect of bovine leukemia virus on the immunological state of cattle. Vet Immunol Immunopathol 1996, 54, 293-302   DOI   PUBMED   ScienceOn
23 Wu D, Takahashi K, Takahashi K, Liu N, Koguchi A, Makara M, Sasaki J, Goryo M, Okada K. Distribution of T-lymphocyte subpopulation in blood and spleen of normal cattle and cattle with enzootic bovine leukosis. J Comp Path 1999, 120, 117-127   DOI   ScienceOn
24 Bendixen HJ. Bovine enzootic leukosis. Advance in Vet Sci and Comp Med 1965, 10, 129-204
25 Carter RF, Valli VEO, Lumsden JH. The cytology, histology and prevalence of cell types in canine lymphoma according to the National Cancer Institute Working Formulation. Can J Vet Res 1986, 50, 154-164
26 Jun MH, Chung UI, Lee CK, Lee CK, Baig SY, Lim CH. Seroepizootiological study on bovine leukosis in Korea. Korean J Vet Res 1982, 22, 175-185
27 Parodi AL. Classification of malignant lymphoma in domestic animals: History and conceptual evolution. Eur J Vet Pathol 2001, 7, 43-50
28 Radostitis OM, Blood DC, Gay CC. Veterinary medicine. 8th ed. pp. 54-65, Bailliere Tindall, London, 1994