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The effect of calcium administration on the blood coagulationmechanism during heparin infusion  

Kim, Il-ryong (Department of Veterinary Medicine, Cheju National University)
Kim, Gon-hyung (National University of Singapore)
Kim, Byungsun (Korea Racing Assocoation)
Yun, Young-min (Department of Veterinary Medicine, Cheju National University)
Lee, Kyoung-kap (Department of Veterinary Medicine, Cheju National University)
Publication Information
Korean Journal of Veterinary Research / v.44, no.3, 2004 , pp. 469-473 More about this Journal
Abstract
This study was performed to investigate the effects of calcium administration on the blood coagulation mechanism through APTT in the calf. Five male calves (70~90 kg) were used in this experiment. In the control group, heparinized normal saline (1 IU/kg/min) had been infusing into the jugular vein for 100 minutes. For the analysis of calcium effects on the APTT, the same solutions had been infusing during the first 40 minutes, subsequently the solution including calcium gluconate (3.3 mg/ml/min) had been infusing for 60 minutes. Blood samples were serially collected every 10 minutes for the APTT and platelets count and every 20 minutes for the calicum level during the infusion. In the calcium-treated group, after 70 minutes the APTT ratio (APTT heparin/APTT baseline) was higher than the therapeutic range. APTT was significantly increased at 50, 60 and 70 minutes in the calcium-treated group as compared to the control group (p<0.01). In the control group, calcium level was decreased significantly after heparin infusion (p<0.01). The platelet count was gradually decreased without significant variation in the both control and calcium-treated groups. These results suggested that APTT is slightly increased in combined heparin and calcium administration.
Keywords
heparin; calcium gluconate; APTT; platelet count; calf;
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