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Control of canine respiratory and diarrheal disease using egg yolk antibodies II. Immunoprophylatic effect of egg yolk antibodies in mice and dogs  

Lee, Hee-Soo (National Veterinary Research and Quarantine Services)
Kim, Jong-man (National Veterinary Research and Quarantine Services)
Woo, Seung-ryong (National Veterinary Research and Quarantine Services)
Jeong, Byeong-yeal (National Veterinary Research and Quarantine Services)
Cho, Yun-Sang (National Veterinary Research and Quarantine Services)
Yoo, Han-sang (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
Yoon, Yong-dhuk (Green Cross Veterinary Science Institute)
Huh, Won (Dae Sung Microbiology Laboratory)
Mun, Young-sik (Dae Sung Microbiology Laboratory)
Oh, Jin-sik (Green Cross Veterinary Science Institute)
Publication Information
Korean Journal of Veterinary Research / v.44, no.3, 2004 , pp. 415-420 More about this Journal
Abstract
Immunoprophylatic effect of IgY against B. bronchispetica was proven with 100% preventive rate in mice administrated with IgY with antibody titer 1:640~1:2,560. Intramuscular administration was more efficient than oral administration. This phenomenon was also observed in the therapeutic effects of IgY after challenge with B. bronchseptica in mice. In the field trials with the egg yolk antibodies from hens immunized with combined antigens with B. bronchiseptica and parvovirus, curing rates in dogs with severe clnical signs such as bloody diarrhea were 81.6% and 86.7% by intramuscular or subcutaneous administration of IgY, respectively. Safety of the antibodies in dogs was proven without any side effects such as vomiting, edema, fever, etc. by adminstration of double doses for 7 days. These results indicated that the egg yolk antibodies could be used as effective prevention and treatment of alimentary and respiratory diseases in dogs.
Keywords
egg yolk antibodies; B. bronchiseptica; Parvovirus; therapeutic effects;
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