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Effects of caffeine on capsular fibrous proliferation induced by N-bis(2-hydroxypropyl)nitrosamine and sulfadimethoxine in the thyroid glands  

Son, Hwa-young (College of Veterinary Medicine, Chungnam National University)
Yoon, Won-kee (Korea Research Institute of Bioscience and Biotechnology)
Jee, Young-heun (Department of Veterinary Medicine, Cheju National University)
Ryu, Si-yoon (College of Veterinary Medicine, Chungnam National University)
Kim, Jung-ran (Statistical Training Center, National Institute of Professional Administration)
Cho, Sung-whan (College of Veterinary Medicine, Chungnam National University)
Publication Information
Korean Journal of Veterinary Research / v.43, no.4, 2003 , pp. 683-688 More about this Journal
Abstract
Caffeine (1,3,7-trimethylxanthine), a central nervous system stimulant, is contained in various foods, beverages and over-the-counter medications. Sulfadimethoxine (SDM) is one of the anti-thyroid agents and induces proliferation of thyroid capsule in two stage thyroid carcinogenesis model using N-bis(2-hydroxypropyl)nitrosamine (DHPN). In this study, we examined the effect of caffeine on fibrous proliferation of thyroid capsule in DHPN and SDM-treated rats. Five-week-old male F344 rats were given a single subcutaneous injection of DHPN (2,800 mg/kg, body weight). Starting one week thereafter, SDM (1,000 ppm in drinking water) with or without caffeine (1,500 ppm in diet) was administered for 12 weeks. All animals were autopsied and histopathological examination of the thyroid glands was performed. Thyroid follicular proliferative changes were induced in all rats treated with DHPN+SDM. In addition, the proliferation of perithyroidal fibrous tissue and pleomorphic thyroid follicular cells within the capsule were observed in DHPN+SDM treated group. Caffeine would not be related to these lesions in this experimental condition. although pentoxifylline, a methyl xanthine derivative, has an anti fibrotic effects.
Keywords
caffeine; sulfadimethoxine; capsular fibrosis; histopathology;
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