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A case of Hydrocephalus in S/D Rat with the Closure of Mesencephalic Aqueduct  

Cho, Ik-Hyun (College of Veterinary Medicine, Konkuk University)
Han, Kyu-Bo (Samsung Veterinary Hospital)
Chang, Byung-Joon (College of Veterinary Medicine, Konkuk University)
Publication Information
Korean Journal of Veterinary Research / v.42, no.3, 2002 , pp. 429-436 More about this Journal
Abstract
Hydrocepbalus may be an acquired or a congenital condition. We have studied the macroscopic and microscopic changes in the hydrocephalus of an inbred Sprague-Dawley rat at postnatal week 8. The animal suspected with the hydrocephalus showed clinical syndromes such as depression, severe ataxia, eye abnormalities, dome-shaped head, and persistent fontanelle. With the postmortem examination, the suspected animal was clearly revealed as a severe internal hydrocephalus. In this animal, severe ventriculomegaly was limited to the third and lateral ventricles, and cortical thining was most apparent in the parieto-occipital region. With the routine histological examination, brain tissue showed aqueductal obstruction, thinning of the cerebral cortex, severe ependymal damage, subependymal edema, damage of choroid plexus of fourth ventricle, enlarged cortical vessels, and expanded ventricles. Aqueductal obstruction was observed with the appearance of simple stenosis at the level of rostral colliculus. Subsequently, the other structures of brain such as septal nucleus, caudate nucleus, and hippocampus etc. were abnormally reconstructed by hydrocephalus. This study suggests that the hydrocephalus can be taken place by primary aqueductal obstruction and this type of hydrocephalus is classified as uncommunicating type. Though the mechanism of aqueductal obstruction is not clear, the morphological studies of this case may be helpful for the further study of hydrocephalus.
Keywords
Sprague-Dawley rat; spontaneous; mesencephalic aqueduct; hydrocephalus;
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