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Park JB, Kario K, Wang JG. Systolic hypertension: an increasing clinical challenge in Asia. Hypertens Res 2015;38:227-36.
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Kario K. Essential manual of 24-hour blood pressure management from morning to nocturnal hypertension. London, UK; Wiley-Blackwell; 2015. p. 1-138.
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Endo K, Kario K, Koga M, et al. Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry. Stroke 2013;44:816-8.
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Tanaka E, Koga M, Kobayashi J, et al. Blood pressure variability on antihypertensive therapy in acute intracerebral hemorrhage: the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-intracerebral hemorrhage study. Stroke 2014;45:2275-9.
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Nagai M, Hoshide S, Nishikawa M, Masahisa S, Kario K. Visit-to-visit blood pressure variability in the elderly: associations with cognitive impairment and carotid artery remodeling. Atherosclerosis 2014;233:19-26.
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Palatini P, Reboldi G, Beilin LJ, et al. Added predictive value of night-time blood pressure variability for cardiovascular events and mortality: the Ambulatory Blood Pressure-International Study. Hypertension 2014;64:487-93.
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Kario K, Pickering TG, Hoshide S, et al. Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system. Am J Hypertens 2004;17:668-75.
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Kario K. Benefits of strict blood-pressure lowering in hypertension. Nat Rev Cardiol 2016;13:125-6.
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Kario K, Saito I, Kushiro T, et al. Morning home blood pressure is a strong predictor of coronary artery disease. J Am Coll Cardiol 2016;67:1519-27.
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Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med 1991;325:986-90.
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Kario K, Matsui Y, Shibasaki S, et al.; Japan Morning Surge-1 (JMS-1) Study Group. An alpha-adrenergic blocker titrated by self-measured blood pressure recordings lowered blood pressure and microalbuminuria in patients with morning hypertension: the Japan Morning Surge-1 Study. J Hypertens 2008;26:1257-65.
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Krum H, Schlaich MP, Sobotka PA, et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet 2014;383:622-9.
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Esler MD, Krum H, Schlaich M et al; Symplicity HTN-2 Investigators. Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 2012;126:2976-82.
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Hering D, Lambert EA, Marusic P, et al. Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension. Hypertension 2013;61:457-64.
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Imai Y, Ohkubo T, Sakuma M, et al. Predictive power of screening blood pressure, ambulatory blood pressure and blood pressure measured at home for overall and cardiovascular mortality: a prospective observation in a cohort from Ohasama, northern Japan. Blood Press Monit 1996;1:251-4.
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Kario K, Shimada K, Schwartz JE, Matsuo T, Hoshide S, Pickering TG. Silent and clinically overt stroke in older Japanese subjects with white-coat and sustained hypertension. J Am Coll Cardiol 2001;38:238-45.
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Kario K, Pickering TG, Umeda Y, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation 2003; 107:1401-6.
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Clement DL, De Buyzere ML, De Bacquer DA, et al; Office versus Ambulatory Pressure Study Investigators. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med 2003;348:2407-15.
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Ohkubo T, Kikuya M, Metoki H, et al. Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study. J Am Coll Cardiol 2005;46:508-15.
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Kagitani H, Hoshide S, Kario K. Optimal indicators of home BP variability in perimenopausal women and associations with albuminuria and reproducibility: The J-HOT home BP study. Am J Hypertens 2015;28:586-94.
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Kario K, Tomitani N, Matsumoto Y, et al. Research and development of information and communication technology-based home blood pressure monitoring from morning to nocturnal hypertension. Ann Glob Health 2016;82:254-73.
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Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 2009;361:932-4.
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Kario K, Okura A, Okawara Y, Tomitani N, Ikemoto T, Hoshide S. Impact of introducing catheter-based renal denervation into Japan for hypertension management: Estimation of number of target patients and clinical relevance of ambulatory blood pressure reduction. Cur Hypertens Rev 2016;12:156-63.
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Parati G, Ochoa JE, Lombardi C, Bilo G. Assessment and management of blood-pressure variability. Nat Rev Cardiol 2013;10:143-55.
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Kario K. Prognosis in relation to blood pressure variability: Pro side of the argument. Hypertension 2015;65:1163-9.
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Rakugi H, Ogihara T, Saruta T, et al; COLM Investigators. Preferable effects of olmesartan/calcium channel blocker to olmesartan/diuretic on blood pressure variability in very elderly hypertension: COLM study subanalysis. J Hypertens 2015;33:2165-72.
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Shibasaki S, Hoshide S, Eguchi K, Ishikawa J, Kario K; Japan Morning Surge-Home Blood Pressure (J-HOP) Study Group. Increase trend in home blood pressure on a single occasion is associated With B-type natriuretic peptide and the estimated glomerular filtration rate. Am J Hypertens 2015;28:1098-105.
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Liu Z, Zhao Y, Zhang H, et al. Excessive variability in systolic blood pressure that is self-measured at home exacerbates the progression of brain white matter lesions and cognitive impairment in the oldest old. Hypertens Res 2016;39:245-53.
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Kario K, Eguchi K, Nakagawa Y, Motai K, Shimada K. Relationship between extreme dippers and orthostatic hypertension in elderly hypertensive patients. Hypertension 1998;31:77-82.
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Kario K, Eguchi K, Hoshide S, et al. U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor. J Am Coll Cardiol 2002;40:133-41.
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Kario K. Orthostatic hypertension: a measure of blood pressure variation for predicting cardiovascular risk. Circ J 2009;73:1002-7.
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Kario K. Obstructive sleep apnea syndrome and hypertension: ambulatory blood pressure. Hypertens Res 2009;32:428-32.
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Kario K, Ogawa H, Okumura K, et al; SYMPLICITY HTN-Japan Investigators. SYMPLICITY HTN-Japan-first randomized controlled trial of catheterbased renal denervation in Asian patients. Circ J 2015;79:1222-9.
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Kario K, Bhatt DL, Brar S, Cohen SA, Fahy M, Bakris GL. Effect of Catheter-Based Renal Denervation on Morning and Nocturnal Blood Pressure: Insights From SYMPLICITY HTN-3 and SYMPLICITY HTN-Japan. Hypertension 2015;66:1130-7.
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Shirasaki O, Kuwabara M, Saito M, Tagami K, Washiya S, Kario K. Development and clinical application of a new technique for detecting ‘sleep blood pressure surges' in sleep apnea patients based on a variable desaturation threshold. Hypertens Res 2011;34:922-8.
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Kario K, Kuwabara M, Hoshide S, Nagai M, Shimpo M. Effects of nighttime single-dose administration of vasodilating vs. sympatholytic antihypertensive agents on sleep blood pressure in hypertensive patients with sleep apnea syndrome. J Clin Hypertens 2014;16:459-66.
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Kario K. New insight of morning blood pressure surge into the triggers of cardiovascular disease-synergistic resonance of blood pressure variability. Am J Hypertens 2016; 29:14-6.
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Kario K. Orthostatic hypertension-a new haemodynamic cardiovascular risk factor. Nat Rev Nephrol 2013;9:726-38.
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Kario K. Proposal of a new strategy for ambulatory blood pressure profile-based management of resistant hypertension in the era of renal denervation. Hypertens Res 2013;36:478-84.
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Kario K. Systemic hemodynamic atherothrombotic syndrome: a blind spot in the current management of hypertension. J Clin Hypertens (Greenwich) 2015;17:328-31.
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Kario K. Morning surge in blood pressure: a phenotype of systemic hemodynamic atherothrombotic syndrome. Am J Hypertens 2015;28:7-9.
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Matsui Y, Ishikawa J, Eguchi K, Shibasaki S, Shimada K, Kario K. Maximum value of home blood pressure: a novel indicator of target organ damage in hypertension. Hypertension 2011;57:1087-93.
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Kuwabara M, Kario K. Development of a triggered nocturnal blood pressure monitoring which detects nighttime blood pressure surges in sleep apnea syndrome. Curr Hypertens Rev 2016;12:27-31.
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Yoshida T, Kuwabara M, Hoshide S, Kario K. Recurrence of stroke caused by nocturnal hypoxia-induced blood pressure surge in a young adult male with severe obstructive sleep apnea syndrome. J Am Soc Hypertens 2016;10:201-4.
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Kario K, Hamasaki H. Nocturnal Blood Pressure Surge Behind Morning Surge in Obstructive Sleep apnea syndrome: another phenotype of systemic hemodynamic atherothrombotic syndrome. J Clin Hypertens (Greenwich) 2015;17:682-5.
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Kikuya M, Ohkubo T, Metoki H, et al. Day by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis: the Ohasama study. Hypertension 2008;52:1045-50.
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Ito S, Nagasawa T, Abe M, Mori T. Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk. Hypertens Res 2009;32:115-21.
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Nakase T, Yoshioka S, Sasaki M, Suzuki A. Clinical evaluation of lacunar infarction and branch atheromatous disease . J Stroke Cerebrovasc Dis 2013;22:406-12.
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Kario K, Pickering TG. Blood pressure variability in elderly patients. Lancet 2000;355:1645-6.
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Matsui Y, Eguchi K, Shibasaki S, et al; Japan morning Surge‐1 Study Group. Impact of arterial stiffness reduction on urinary albumin excretion during antihypertensive treatment: the Japan morning Surge‐1 study. J Hypertens 2010;28:1752-60.
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Kario K. Morning surge in blood pressure and cardiovascular risk – evidence and perspectives. Hypertension 2010;56:765-73.
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Li Y, Thijs L, Hansen TW, et al; International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators. Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations. Hypertension 2010;55:1040-8.
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Verdecchia P, Angeli F, Mazzotta G, et al. Day-night dip and early-morning surge in blood pressure in hypertension: prognostic implications. Hypertension 2012;60:34-42.
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Kario K, Ikemoto T, Kuwabara M, Ishiyama H, Saito K, Hoshide S. Catheter-based renal denervation reduces hypoxia-triggered nocturnal blood pressure peak in obstructive sleep apnea syndrome. J Clin Hypertens (Greenwich) 2015. [in press]
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Kario K, Bhatt DL, Kandzari DE, et al. Impact of renal denervation on patients with obstructive sleep apnea and resistant hypertension: insights from the SYMPLICITY HTN-3 trial. Circ J 2016;80:1404-12.
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Kandzari D, Kario K, Mahfoud F, et al. The SPYRAL HTN global clinical trial program: rationale and design for studies of renal denervation in the absence (SPYRAL HTN OFF-MED) and presence (SPYRAL HTN ON-MED) of antihypertensive medications. Am Heart J 2016;171;82-91.
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Muntner P, Shimbo D, Tonelli M, Reynolds K, Arnett DK, Oparil S. The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994. Hypertension 2011;57:160-6.
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Matsui Y, O'Rourke MF, Hoshide S, Ishikawa J, Shimada K, Kario K. Combined effect of angiotensin II receptor blocker and either a calcium channel blocker or diuretic on day-by-day variability of home blood pressure: the Japan Combined Treatment With Olmesartan and a Calcium-Channel Blocker Versus Olmesartan and Diuretics Randomized Efficacy Study. Hypertension 2012;59:1132-8.
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Eguchi K, Hoshide S, Schwartz JE, Shimada K, Kario K. Visit-to-visit and ambulatory blood pressure variability as predictors of incident cardiovascular events in patients with hypertension. Am J Hypertens 2012;25:962-8.
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Yokota K, Fukuda M, Matsui Y, Hoshide S, Shimada K, Kario K. Impact of visit-to-visit variability of blood pressure on deterioration of renal function in patients with non-diabetic chronic kidney disease. Hypertens Res 2013;36:151-7.
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Nagai M, Hoshide S, Ishikawa J, Shimada K, Kario K. Visit-to-visit blood pressure variations: new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease. J Hypertens 2012;30:1556-63.
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Nagai M, Hoshide S, Nishikawa M, Shimada K, Kario K. Sleep duration and insomnia in the elderly: associations with blood pressure variability and carotid artery remodeling. Am J Hypertens 2013;26:981-9.
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Nagai M, Kario K. Visit-to-visit blood pressure variability, silent cerebral injury, and risk of stroke. Am J Hypertens 2013;26:1369-76.
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Hoshide S, Kario K, de la Sierra A, et al. Ethnic differences in the degree of morning blood pressure surge and in its determinants between Japanese and European hypertensive subjects: data from the ARTEMIS study. Hypertension 2015;66:750-6.
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Kario K. Caution for winter morning surge in blood pressure: a possible link with cardiovascular risk in the elderly. Hypertension 2006;47:139-40.
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Murakami S, Otsuka K, Kubo Y, et al. Repeated ambulatory monitoring reveals a Monday morning surge in blood pressure in a community-dwelling population. Am J Hypertens 2004;17:1179-83.
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Kario K. Clinician's manual on early morning risk management in hypertension. London, UK; Science Press; 2004. p.1-68.
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Kario K, Ishikawa J, Pickering TG, et al. Morning hypertension: the strongest independent risk factor for stroke in elderly hypertensive patients. Hypertens Res 2006;29:581-7.
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Kario K, Eguchi K, Umeda Y, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: response. Circulation 2003;108:e72-3.
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Hoshide S, Kario K, Yano Y, et al; J‐HOP study group. Association of morning and evening blood pressure at home with asymptomatic organ damage in the J-HOP Study. Am J Hypertens 2014;27:939-47.
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Kario K, Saito I, Kushiro T, et al. Home blood pressure and cardiovascular outcomes in patients during antihypertensive therapy: primary results of HONEST, a large‐scale prospective, real‐world observational study. Hypertension 2014;64:989-96.
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