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http://dx.doi.org/10.4070/kcj.2016.46.2.135

Hypertriglyceridemia and Cardiovascular Diseases: Revisited  

Han, Seung Hwan (Department of Cardiology, Gachon University Gil Medical Center)
Nicholls, Stephen J (Department of Cardiology, South Australian Health and Medical Research Institute, University of Adelaide)
Sakuma, Ichiro (Department of Cardiovascular Medinine, Hokko Memorial Clinic)
Zhao, Dong (Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing An Zhen Hospital, Capital Medical University)
Koh, Kwang Kon (Department of Cardiology, Gachon University Gil Medical Center)
Publication Information
Korean Circulation Journal / v.46, no.2, 2016 , pp. 135-144 More about this Journal
Abstract
Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
Keywords
Residual cardiovascular risk; Hypertriglyceridemia; Treatment; Cardiovascular disease;
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