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http://dx.doi.org/10.4070/kcj.2014.44.6.406

Usefulness of the Doppler Flow of the Ophthalmic Artery in the Evaluation of Carotid and Coronary Atherosclerosis  

Hong, Seung Pyo (Department of Cardiology, Daegu Catholic University Medical Center)
Park, Yon Woong (Department of Cardiology, Daegu Catholic University Medical Center)
Lee, Chan Wook (Department of Cardiology, Daegu Catholic University Medical Center)
Park, Joung Won (Department of Cardiology, Daegu Catholic University Medical Center)
Bae, Kyung Ryun (Department of Cardiology, Daegu Catholic University Medical Center)
Jun, Seung Woon (Department of Cardiology, Daegu Catholic University Medical Center)
Lee, Young Soo (Department of Cardiology, Daegu Catholic University Medical Center)
Lee, Jin Bae (Department of Cardiology, Daegu Catholic University Medical Center)
Ryu, Jae Kean (Department of Cardiology, Daegu Catholic University Medical Center)
Choi, Ji Yong (Department of Cardiology, Daegu Catholic University Medical Center)
Chang, Sung Guk (Department of Cardiology, Daegu Catholic University Medical Center)
Kim, Kee Sik (Department of Cardiology, Daegu Catholic University Medical Center)
Publication Information
Korean Circulation Journal / v.44, no.6, 2014 , pp. 406-414 More about this Journal
Abstract
Background and Objectives: There is little information about the relationship between the Doppler flow of the ophthalmic artery (OA) and carotid and coronary atherosclerosis. The aim of the investigation was to assess the clinical usefulness of the Doppler flow of the OA to estimate the severity of carotid and coronary atherosclerosis. Subjects and Methods: The study was a retrospective analysis of the findings in 140 patients (mean age: 60 years, male: 64%) who underwent coronary angiography (CA) for the evaluation of typical angina between July 2010 and October 2011 in our single center. The severity of coronary artery stenosis was based on the Gensini score (GS). Significant coronary artery disease (CAD) was defined as the obstruction of over 75% of the major coronary arteries confirmed with CA. The pulsed Doppler flow of the OA and carotid ultrasound were performed before CA. Results: The mean systolic velocity/mean diastolic velocity (MSV/MDV), pulsatile index and resistance index in the Doppler flow of the OA were identified as significant and independent correlations with carotid intima-media thickness, and MSV/MDV was identified to have a significant and independent correlation with the GS. MSV/MDV >2.1 was the independent predictor for significant CAD {odds ratio (OR) 3.8, 95% confidence interval (CI) 1.5-9.7, p=0.005} and carotid plaque (OR 2.8, 95% CI 1.1-7.0, p=0.028), after adjustment for CAD-associated factors. Conclusion: The Doppler flow of the OA might be a useful predictor of the severity of carotid and coronary atherosclerosis.
Keywords
Atherosclerosis; Carotid arteries; Coronary vessels; Ophthalmic artery; ultrasound;
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1 Burger-Kentischer A, Gobel H, Kleemann R, et al. Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF). Atherosclerosis 2006; 184:28-38.   DOI   ScienceOn
2 Stein JH, Korcarz CE, Hurst RT, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008;21: 93-111; quiz 189-90.   DOI   ScienceOn
3 Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007;115:459-67.   DOI   ScienceOn
4 Zielinski T, Dzielinska Z, Januszewicz A, et al. Carotid intima-media thickness as a marker of cardiovascular risk in hypertensive patients with coronary artery disease. Am J Hypertens 2007;20:1058-64.   DOI
5 Ralph RA. Prediction of cardiovascular status from arteriovenous crossing phenomena. Ann Ophthalmol 1974;6:323-6.
6 Michelson EL, Morganroth J, Nichols CW, MacVaugh H 3rd. Retinal arteriolar changes as an indicator of coronary artery disease. Arch Intern Med 1979;139:1139-41.   DOI
7 Gillum RF. Retinal arteriolar findings and coronary heart disease. Am Heart J 1991;122(1 Pt 1):262-3.   DOI   ScienceOn
8 Wong TY, Klein R, Klein BE, Tielsch JM, Hubbard L, Nieto FJ. Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Surv Ophthalmol 2001;46:59-80.   DOI   ScienceOn
9 Tedeschi-Reiner E, Strozzi M, Skoric B, Reiner Z. Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery disease. Am J Cardiol 2005;96:1107-9.   DOI
10 Maruyoshi H, Kojima S, Kojima S, et al. Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis. Circ J 2010;74:1251-6.   DOI
11 Hu HH, Sheng WY, Yen MY, Lai ST, Teng MM. Color Doppler imaging of orbital arteries for detection of carotid occlusive disease. Stroke 1993; 24:1196-203.   DOI
12 Guidelines Committee European Society of Hypertension. European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003;21:1011-53.   DOI   ScienceOn
13 ADA Statement. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013;36:67-74.   DOI
14 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.   DOI   ScienceOn
15 Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.   DOI   ScienceOn
16 Lieb WE, Cohen SM, Merton DA, Shields JA, Mitchell DG, Goldberg BB. Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol 1991;109:527-31.   DOI   ScienceOn
17 Yatsuka Y, Matsukubo S, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S. Ophthalmic artery flow velocity after physical exercise in healthy men. Jpn J Ophthalmol 1996;40:103-10.
18 Metz CE, Herman BA, Shen JH. Maximum likelihood estimation of receiver operating characteristic (ROC) curves from continuously-distributed data. Stat Med 1998;17:1033-53.   DOI   ScienceOn
19 National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.
20 Tranquart F, Berges O, Koskas P, et al. Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 2003;31:258-73.   DOI
21 Pearson TA, Blair SN, Daniels SR, et al. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation 2002;106:388-91.   DOI   ScienceOn
22 Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42:1206-52.   DOI   ScienceOn
23 Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003;108:2154-69.   DOI   ScienceOn
24 Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-39.   DOI   ScienceOn
25 Dzau VJ, Antman EM, Black HR, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation 2006;114:2850-70.   DOI
26 Matthiessen ET, Zeitz O, Richard G, Klemm M. Reproducibility of blood flow velocity measurements using colour decoded Doppler imaging. Eye (Lond) 2004;18:400-5.   DOI
27 Nemeth J, Kovacs R, Harkanyi Z, Knezy K, Senyi K, Marsovszky I. Observer experience improves reproducibility of color Doppler sonography of orbital blood vessels. J Clin Ultrasound 2002;30:332-5.   DOI
28 Paivansalo M, Pelkonen O, Rajala U, Keinanen-Kiukaanniemi S, Suramo I. Diabetic retinopathy: sonographically measured hemodynamic alterations in ocular, carotid, and vertebral arteries. Acta Radiol 2004;45: 404-10.   DOI
29 Fukuda M, Suzuki A, Okamoto N, Tsubakimori S. Investigation of Doppler ultrasound waveform indices in the ophthalmic artery: comparison between results in normal and diabetic eyes. Folia Ophthalmol Jpn 1999;50:218-23.
30 Paivansalo M, Riihelainen K, Rissanen T, Suramo I, Laatikainen L. Effect of an internal carotid stenosis on orbital blood velocity. Acta Radiol 1999;40:270-5.   DOI