Slow Coronary Flow Phenomenon and Increased Platelet Volume Indices

Background and Objectives: We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF). Subjects and Methods: Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as control group. Baseline characteristics and laboratory data were collected before angiography. Results: Platelet volume indices MPV ($10.8{\pm}1.2$ fL), PDW ($14.5{\pm}2.2$ fL), and P-LCR ($30.5{\pm}8.1$%) in the SCF group were significantly (p<0.05) higher than those ($10.1{\pm}0.9$ fL, $13.2{\pm}1.8$ fL, and $26.8{\pm}6.8$%, respectively) in the NCF group. The patients with three SCF arteries had significantly higher platelet volume indices compared to those with NCF arteries; however, the patients with one SCF artery did not. Based on linear regression model, MPV, PDW, and P-LCR were independent predictors of mean infarction frame counting (TFC). In multivariate analysis, MPV {odds ratio (OR)=32.393, 95% confidence interval (CI)=1.189-882.606, p=0.039} and P-LCR (OR=0.566, 95% CI=0.330-0.937, p=0.028) were independent predictors of SCF. Conclusion: Platelet volume indices MPV, PDW, and P-LCR were associated with both the presence and extent of SCF.