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http://dx.doi.org/10.4070/kcj.2012.42.5.345

Recurrent Deep Vein Thrombosis due to Thrombophilia  

Rahman, Afzalur (Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital)
Islam, AKM Monwarul (Department of Cardiology, National Institute of Cardiovascular Diseases)
Husnayen, SAM (Department of Cardiology, Zia Heart Foundation Hospital and Research Institute)
Publication Information
Korean Circulation Journal / v.42, no.5, 2012 , pp. 345-348 More about this Journal
Abstract
Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.
Keywords
Deep vein thrombosis; Thrombophilia;
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