Browse > Article
http://dx.doi.org/10.12989/amr.2017.6.1.001

Ultraviolet-ozone irradiation of HPMC thin films: Structural and thermal properties  

Abdel-Zaher, Nabawia A. (Textile Metrology Lab, National Institute for Standards)
Moselhey, Manal T.H. (Al-Safwa High Institute of Engineering)
Guirguis, Osiris W. (Department of Biophysics, Faculty of Science, Cairo University)
Publication Information
Advances in materials Research / v.6, no.1, 2017 , pp. 1-12 More about this Journal
Abstract
The aim of the work was to evaluate the effect of ultraviolet-ozone ($UV-O_3$) irradiation with different times on the structure and thermal properties of hydroxypropyl methylcellulose (HPMC) in the form of a thin film to be used as bioequivalent materials according to their important broad practical and medical applications. HPMC thin films were exposed to $UV-O_3$ radiation in air at a wavelength of 184.9 nm.The beneficial effects of this treatment on the crystallinity and amorphousity regions were followed by X-ray diffraction technique and FTIR spectroscopy. Differential scanning calorimetry, thermogravimetric and differntial thermal analyses were used in order to study the thermal properties of HPMC samples following the process of photodegradation. The obtained results indicated that the rate of degradation process was increased with increasing the exposure time. Variations in shape and area of the thermal peaks were observed which may be attributed to the different degrees of crystallinity after exposing the treated HPMC samples. This meant a change in the amorphousity of the treated samples, the oxidation of its chemical linkages on its surface and its bulk, and the formation of free radical species as well as bond formation.
Keywords
HPMC; photodegradation; X-ray diffraction; FTIR spectroscopy; thermal properties;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Abd El-Kader, F.H., Gaafar, S.A., Mahmoud, K.H., Bannan, S.I. and Abd El-Kader, M.F.H. (2008), "${\gamma}$-irradiation effects on the thermal and optical properties of undoped and eosin doped 70/30 (wt/wt%) PVA/glycogen films", Curr. Appl. Phys., 8(1), 78-87.   DOI
2 Bernard, C., Chaussedent, S., Monteil, A., Montagna, M., Zampedri, L. and Ferrari, M. (2003), "Simulation by molecular dynamics of erbium-activated silica-titania glasses", J. Sol-Gel Sci. Technol., 26(1), 925-929.   DOI
3 Bolon, D.A. and Kunz, C.O. (1972), "Ultraviolet depolymerization of photoresist polymers", Polym. Eng. Sci., 12(2), 109-111.   DOI
4 Bras, A.R., Viciosa, M.T., Dionisio, M. and Mano, J.F. (2007), "Water effect in the thermal and molecular dynamics behaviour of poly(l-lactic acid)", J. Therm. Anal. Calorimet., 88(2), 425-429.   DOI
5 Chiu, J. (1966), "Applications of thermogravimetry to the study of high polymers", Appl. Polym. Symp., 2, 25-43.
6 Cullis, C.F. and Hirschler, M.M. (1981), Combustion of Organic Polymers, Clarendon Press, Oxford, U.K.
7 Desai, R.L. and Shields, J.A. (1969), "Photochemical degradation of cellulose material", Die Makromol. Chem., 122(1), 134-144.   DOI
8 El-Zaher, N.A. and Osiris, W.G. (2005), "Thermal and structural properties of poly(vinyl alcohol) doped with hydroxypropyl cellulose", J. Appl. Polym. Sci., 96(5), 1914-1923.   DOI
9 Ewa, O.K. (2015), "Effect of UV irradiation on thermal properties of nanocomposites based on polylactide", J. Therm. Anal. Calorimet., 119(1), 219-228.   DOI
10 Ferrero, C., Massuelle, D. and Doelker, E. (2010), "Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers: II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis", J. Control. Rel., 141, 223-233.   DOI
11 Gendre, C., Boiret, M., Genty, M., Chaminade, P. and Pean, J.M. (2011), "Real time predictions of drug release and end point detection of a coating operation by in-line near infrared measurements", J. Pharmac., 421(2), 237-243.
12 Ku, M.S., Lu, Q., Li, W. and Chen, Y. (2011), "Performance qualification of a new hypromellose capsule: Part II. Disintegration and dissolution comparison between two types of hypromellose capsules", J. Pharmac., 416(1), 16-24.
13 Hammel, R., MacKnight, W.J. and Karasz, F.E. (1975), "Structure and properties of the system: Poly(2,6-dimethyl-phenylene oxide) isotactic polystyrene wide-angle x-ray studies", J. Appl. Phys., 46(10), 4199-4203.   DOI
14 Hofenk-de, G.J. (1981), Central Research Laboratory for Objects of Art and Science, Gabriel Metsustroat and 1071 EA, Amsterdam, the Netherlands.
15 Kim, J.H., Kim, J.Y., Lee, Y.M. and Kim, K.Y. (1992), "Properties and swelling characteristics of crosslinked poly(vinyl alcohol)/chitosan blend membrane", J. Appl. Polym. Sci., 45(10), 1711-1717.   DOI
16 Lim, S.L., Fane, A.G. and Fell, C.J.D. (1990), "Radiation-induced grafting of regenerated cellulose hollow-fiber membranes", J. Appl. Polym. Sci., 41(7-8), 1609-1616.   DOI
17 Maderuelo, C., Zarzuelo, A. and Lanao, J.M. (2011), "Critical factors in the release of drugs from sustained release hydrophilic matrices", J. Control. Rel., 154(1), 2-19.   DOI
18 Michael, M.N., El-Zaher, N.A. and Ibrahim, S.F. (2004), "Investigation into surface modification of some polymeric fabrics by UV/ozone treatment", Polym.-Plast. Technol. Eng., 43(4), 1041-1052.   DOI
19 Madhu Mohan, V., Raja, V., Sharma, A.K. and Narasimha Rao, V.V.R. (2005), "Ionic conductivity and discharge characteristics of solid-state battery based on novel polymer electrolyte ($PEO+NaBiF_4$)", Mater. Chem. Phys., 94(2), 177-181.   DOI
20 METHOCEL Cellulose Ethers (2002), Technical Handbook, Trademark of the Dow Chemical Company, U.S.A.
21 Paradossi, G., Cavalieri, F., Chiessi, E., Spagnoli, C. and Cowman, M.K. (2003), "Poly(vinyl alcohol) as versatile biomaterial for potential biomedical applications", J. Mater. Sci.: Mater. Medic., 14(8), 687-691.   DOI
22 Nabawia, A., Abdel-Zaher, M.T.H. and Osiris, W.G. (2016), "Optical studies of hydroxypropyl methylcellulose thin films exposed to UV/ozone", J. Sci. Eng. Res., 3, 84-96.
23 Neto, C.G.T., Giacometti, J.A., Job, A.E., Ferreira, F.C., Fonseca, J.L.C. and Pereira, M.R. (2005), "Thermal analysis of chitosan based network", Carbohyd. Polym., 62(2), 97-103.   DOI
24 Osiris, W.G. and Manal, T.H.M. (2011), "Optical study of poly(vinyl alcohol)/hydroxypropyl methylcellulose blends", J. Mater. Sci., 46(17), 5775-5789.   DOI
25 Park, C.K., Choi, M.J. and Lee, Y.M. (1995), "Chelate membrane from poly(vinyl alcohol)/poly(N-salicylidene allyl amine) blend. I: Synthesis and characterization of Co(II) chelate membrane", Polym., 37, 1507-1512.
26 Qiangzhong, Z., Mouming, Z., Jianrong, L., Bao, Y., Guowan, S., Chun, C. and Yueming, J. (2009), "Effect of hydroxypropyl methylcellulose on the textural and whipping properties of whipped cream", Food Hydrocol., 23(8), 2168-2173.   DOI
27 Segal, L., Creely, J.J., Martin Jr, A.E. and Conrad, C.M. (1959), "An empirical method for estimating the degree of crystallinity of native cellulose using the x-ray diffractometer", Text. Res. J., 29(10), 786-794.   DOI
28 Quoc, T.L., Whelan, C.M., Struyf, H., Vanhaelemeersch, S., Azioune, A., Louette, P., Pireaux, J.J. and Maex, K. (2004), "Polymer dielectric treatment using ultraviolet-ozone: A photoelectron spectroscopy and ellipsometric porosimetry study", J. Appl. Phys., 96(7), 3807-3810.   DOI
29 Sakellariou, P., Hassan, A. and Rowe, R.C. (1993), "Phase separation and polymer interactions in aqueous poly(vinyl alcohol)/hydroxypropyl methylcellulose blends", Polym., 34(6), 1240-1248.   DOI
30 Schulz, M.B. and Daniels, R. (2000), "Hydroxypropyl methylcellulose (HPMC) as emulsifier for submicron emulsions: Influence of molecular weight and substitution type on the droplet size after high-pressure homogenization", Eur. J. Pharmac. Biopharmac., 49(3), 231-236.   DOI
31 Siepmann, J. and Peppas, N.A. (2001), "Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)", Adv. Drug Del. Rev., 48, 139-157.   DOI
32 Smith, A.L. (1979), Applied Infrared Spectroscopy, Fundamentals Techniques and Analytical Problem-Solving, Wiley, New York, U.S.A.
33 Smith, B.C. (2011), Fundamentals of Fourier Transform Infrared Spectroscopy, 2nd Edition, CRC Press, Boca Raton, London, New York, U.S.A.
34 Song, P., Chen, G., Wei, Z., Zhang, W. and Liang, J. (2013), "Calorimetric analysis of themultiplemelting behavior ofmelt-crystallized poly(L-lactic acid) with a low optical purity", J. Therm. Anal. Calorimet., 111(2), 1507-1514.   DOI
35 Yukoh, S., Sumihiro, S. and Makoto, O. (2006), "A novel white film for pharmaceutical coating formed by interaction of calcium lactate pentahydrate with hydroxypropyl methylcellulose", J. Pharmac., 317(2), 120-126.
36 Yinghui, W., Xiaoli, Y., Xiaoguang, S., Xuan, P., Qiang, B., Minchen, L., Manman, G. and Fanzhu, L. (2012), "Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS)", Coll. Surf. A: Physicochem. Eng. Asp., 396, 22-28.   DOI