Browse > Article
http://dx.doi.org/10.3350/kjhep.2009.15.3.391

Practice guidelines for management of hepatocellular carcinoma 2009  

Korean Liver Cancer Study Group, (Korean Liver Cancer Study Group)
National Cancer Center, (National Cancer Center)
Publication Information
Clinical and Molecular Hepatology / v.15, no.3, 2009 , pp. 391-423 More about this Journal
Abstract
Hepatocellular carcinoma (HCC) is a major cancer in Korea, typically has a poor prognosis, and constitutes the majority of primary hepatic malignancies. It is the number one cause of death among people in their 50s in Korea. The five-year survival rate of liver cancer is poor; at 18.9%. Efforts to increase the survival rate through early diagnosis of HCC and optimal treatments are keenly needed. Western guideline for the management of HCC were developed, but these guidelines are somewhat unsuitable for Korean patients. Thus, the Korean Liver Cancer Study Group (KLCSG) and the National Cancer Center (NCC), Korea jointly produced the Clinical Practice Guidelines for HCC for the first time in Korea in 2003. Owing to medical advances over the following six years, diagnosis and treatment of HCC has changed considerably. As more national and foreign data are accumulated, KLCSG and NCC, Korea recently revised the Clinical Practice Guidelines for HCC. Forty or more specialists in the field of hepatology, general surgery, radiology and radiation oncology participated, and meticulously reviewed national and foreign papers, and collected opinions through advisory committee conferences. These multidisciplinary, evidence-based guidelines summarized diagnosis, surgical resection, liver transplantation, local treatments, transarterial chemoembolization, radiation therapy, chemotherapy, preemptive antiviral treatments, and response evaluation of HCC. These Korean guidelines are expected to be useful for clinical management of and research on HCC.
Keywords
Hepatocellular carcinoma; Diagnosis; Management; Guidelines;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
Times Cited By SCOPUS : 19
연도 인용수 순위
1 Korean Statistical Information Services
2 Bruix J, Sherman M, Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology 2005; 42:1208-1236   DOI   ScienceOn
3 Ishizuka H, Nakayama T, Matsuoka S, Gotoh I, Ogawa M, Suzuki K, et al. Prediction of the development of hepato-cellular-carcinoma in patients with liver cirrhosis by the serial determinations of serum alpha-L-fucosidase activity. Intern Med 1999;38:927-931   DOI   ScienceOn
4 Yoon YJ, Han KH, Kim C, Chon CY, Moon YM, Han CH, et al. Clinical efficacy of serum PIVKA-II in the diagnosis and follow up after treatment of hepatocellular carcinoma. Korean J Hepatol 2002;8:465-471
5 Zacherl J, Pokieser P, Wrba F, Scheuba C, Prokesch R, Zacherl M, et al. Accuracy of multiphasic helical computed tomography and intraoperative sonography in patients undergoing orthotopic liver transplantation for hepatoma: what is the truth? Ann Surg 2002;235:528-532   DOI   ScienceOn
6 Piscaglia F, Bolondi L. Recent advances in the diagnosis of hepatocellular carcinoma. Hepatol Res 2007;37(Suppl 2): S178-S192   DOI
7 Capussotti L, Muratore A, Massucco P, Ferrero A, Polastri R, Bouzari H. Major liver resections for hepatocellular carcinoma on cirrhosis: early and long-term outcomes. Liver Transpl 2004;10(Suppl 1):S64-S68   DOI   ScienceOn
8 Kim JH, Choi DW, Kim SB. Saftey and long-term outcome following major hepatectomy for hepatocellular carcinoma combined with compensated liver cirrhosis. J Korean Surg Soc 2006;70:444-450
9 Torzilli G, Palmisano A, Del Fabbro D, Marconi M, Donadon M, Spinelli A, et al. Contrast-enhanced intraoperative ultrasonography during surgery for hepatocellular carcinoma in liver cirrhosis: is it useful or useless? A prospective cohort study of our experience. Ann Surg Oncol 2007;14:1347-1355   DOI   ScienceOn
10 Zhang K, Kokudo N, Hasegawa K, Arita J, Tang W, Aoki T, et al. Detection of new tumors by intraoperative ultrasonography during repeated hepatic resections for hepatocellular carcinoma. Arch Surg 2007;142:1170-1175   DOI   ScienceOn
11 Hanazaki K, Kajikawa S, Shimozawa N, Matsushita A, Machida T, Shimada K, et al. Perioperative blood transfusion and survival following curative hepatic resection for hepatocellular carcinoma. Hepatogastroenterology 2005;52:524-529   PUBMED   ScienceOn
12 Tsujita E, Taketomi A, Kitagawa D, Itoh S, Harimoto N, Gion T, et al. Selective hepatic vascular exclusion for the hepatic resection of HCC. Hepatogastroenterology 2007;54: 527-530   PUBMED   ScienceOn
13 Kaneko H, Takagi S, Otsuka Y, Tsuchiya M, Tamura A, Katagiri T, et al. Laparoscopic liver resection of hepatocellular carcinoma. Am J Surg 2005;189:190-194   DOI   ScienceOn
14 Shi M, Zhang CQ, Zhang YQ, Liang XM, Li JQ. Micrometastases of solitary hepatocellular carcinoma and appropriate resection margin. World J Surg 2004;28: 376-381   DOI   ScienceOn
15 Tralhao JG, Kayal S, Dagher I, Sanhueza M, Vons C, Franco D. Resection of hepatocellular carcinoma: the effect of surgical margin and blood transfusion on long-term survival. Analysis of 209 consecutive patients. Hepatogastroenterology 2007;54:1200-1206   PUBMED   ScienceOn
16 Chen HY, Juan CC, Ker CG. Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol 2008;15:800-806   DOI   ScienceOn
17 Vibert E, Perniceni T, Levard H, Denet C, Shahri NK, Gayet B. Laparoscopic liver resection. Br J Surg 2006;93: 67-72   DOI   ScienceOn
18 Pawlik TM, Poon RT, Abdalla EK, Ikai I, Nagorney DM, Belghiti J, et al. Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study. Surgery 2005;137:403-410   DOI   ScienceOn
19 Majno PE, Sarasin FP, Mentha G, Hadengue A. Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcomeoriented decision analysis. Hepatology 2000;31:899-906   DOI   ScienceOn
20 Hwang S, Lee SG, Joh JW, Suh KS, Kim DG. Liver transplantation for adult patients with hepatocellular carcinoma in Korea: comparison between cadaveric donor and living donor liver transplantations. Liver Transpl 2005;11:1265-1272   DOI   ScienceOn
21 Gondolesi GE, Roayaie S, Munoz L, Kim-Schluger L, Schiano T, Fishbein TM, et al. Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria. Ann Surg 2004;239: 142-149   DOI   ScienceOn
22 Llovet JM, Mas X, Aponte JJ, Fuster J, Navasa M, Christensen E, et al. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation. Gut 2002;50:123-128   DOI   ScienceOn
23 Mazzaferro V, Battiston C, Perrone S, Pulvirenti A, Regalia E, Romito R, et al. Radiofrequencyablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study. Ann Surg 2004;240:900-909   DOI   ScienceOn
24 Poon RT, Fan ST, Lo CM, Liu CL, Wong J. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation. Ann Surg 2002;235:373-382   DOI   ScienceOn
25 Ishii M, Gama H, Chida N, Ueno Y, Shinzawa H, TakagiT, et al. Simultaneous measurements of serum alphafetoproteinand protein induced by vitamin K absence fordetecting hepatocellular carcinoma. South Tohoku DistrictStudy Group. Am J Gastroenterol 2000;95:1036-1040   PUBMED
26 Jonas S, Bechstein WO, Steinmuller T, Herrmann M,Radke C, Berg T, et al. Vascular invasion and histopathologicgrading determine outcome after liver transplantationfor hepatocellular carcinoma in cirrhosis. Hepatology 2001;33:1080-1086   DOI   ScienceOn
27 Schwartz M, Roayaie S, Llovet J. How should patientswith hepatocellular carcinoma recurrence after livertransplantation be treated? J Hepatol 2005;43:584-589   DOI   ScienceOn
28 Faria LC, Gigou M, Roque-Afonso AM, Sebagh M, RocheB, Fallot G, et al. Hepatocellular carcinoma is associatedwith an increased risk of hepatitis B virus recurrenceafterliver transplantation. Gastroenterology 2008;134:1890-1899   DOI   ScienceOn
29 Zimmerman MA, Trotter JF, Wachs M, Bak T, CampsenJ, Skibba A, et al. Sirolimus-based immunosuppressionfollowing liver transplantation for hepatocellular carcinoma.Liver Transpl 2008;14:633-638   DOI   ScienceOn
30 Hwang S, Lee SG, Ahn CS, Kim KH, Moon DB, Ha TY,et al. Prevention of hepatitis B recurrence after livingdonor liver transplantation: primary high-dose hepatitis Bimmunoglobulin monotherapy and rescue antiviral therapy.Liver Transpl 2008;14:770-778   DOI   ScienceOn
31 Shiina S, Teratani T, Obi S, Sato S, Tateishi R,Fujishima T, et al. A randomized controlled trial ofradiofrequency ablation with ethanol injection for smallhepatocellular carcinoma. Gastroenterology 2005;129:122-130   DOI   ScienceOn
32 Choi D, Lim HK, Rhim H, Kim YS, Lee WJ, Paik SW, etal. Percutaneous radiofrequency ablation for early-stagehepatocellular carcinoma as a first-line treatment: longtermresults and prognostic factors in a large singleinstitutionseries. Eur Radiol 2007;17:684-692   DOI   ScienceOn
33 Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, ZhangYQ, et al. A prospective randomized trial comparingpercutaneous local ablative therapy and partial hepatectomyfor small hepatocellular carcinoma. Ann Surg 2006;243:321-328   DOI   ScienceOn
34 Daniele B, De Sio I, Izzo F, Capuano G, Andreana A,Mazzanti R, et al. Hepatic resection and percutaneousethanol injection as treatments of small hepatocellularcarcinoma: a Cancer of the Liver Italian Program (CLIP08) retrospective case-control study. J Clin Gastroenterol 2003;36:63-67   DOI   ScienceOn
35 Becker G, Soezgen T, Olschewski M, Laubenberger J, Blum HE, Allgaier HP. Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma. World J Gastroenterol 2005;11:6104-6109   DOI   PUBMED
36 Lee HS, Kim KM, Yoon JH, Lee TR, Suh KS, Lee KU, et al. Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study. J Clin Oncol 2002;20:4459-4465   DOI   ScienceOn
37 Chung JW, Park JH, Han JK, Choi BI, Han MC. Hepatocellular carcinoma and portal vein invasion: results of treatment with transcatheter oily chemoembolization. AJR Am J Roentgenol 1995;165:315-321   DOI   PUBMED   ScienceOn
38 Park JH, Chung JW, Lee SK, Han JK, Lee HS, Kim CY, et al. Chemoembolization of hepatocellular carcinoma: long-term survival and prognostic factors. J Korean Radiol Soc 1996;35:315-323
39 Hong K, Khwaja A, Liapi E, Torbenson MS, Georgiades CS, Geschwind JF. New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res 2006;12:2563-2567   DOI   ScienceOn
40 Kulik LM, Carr BI, Mulcahy MF, Lewandowski RJ, Atassi B, Ryu RK, et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology 2008;47:71-81   DOI   ScienceOn
41 Riaz A, Kulik L, Lewandowski RJ, Ryu RK, Giakoumis Spear G, Mulcahy MF, et al. Radiologic-pathologic correlation of hepatocellular carcinoma treated with internal radiation using yttrium-90 microspheres. Hepatology 2009;49:1185-1193   DOI   ScienceOn
42 Seong J, Lee IJ, Shim SJ, Lim do H, Kim TH, Kim JH, et al. A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea. Liver Int 2009;29:147-152   DOI   PUBMED   ScienceOn
43 Guo WJ, Yu EX. The long-term efficacy of combined chemoembolization and local irradiation in the treatment of patients with large hepatocellular carcinoma. Hepatogastroenterology 2003;50:500-503   PUBMED
44 Seong J, Park HC, Han KH, Chon CY. Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: a retrospective study of 158 patients. Int J Radiat Oncol Biol Phys 2003;55:329-336   DOI   PUBMED   ScienceOn
45 Kim TH, Kim DY, Park JW, Kim SH, Choi JI, Kim HB, et al. Dose-volumetric parameters predicting radiationinduced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2007;67:225-231   DOI   PUBMED   ScienceOn
46 Cheng SH, Lin YM, Chuang VP, Yang PS, Cheng JC, Huang AT, et al. A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma. J Gastroenterol Hepatol 1999;14:1025-1033   DOI   ScienceOn
47 Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H, Nakamura N, etal. Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: retrospective study. J Gastroenterol Hepatol 2007;22: 523-527   DOI   ScienceOn
48 Seong J, Koom WS, Park HC. Radiotherapy for painful bone metastases from hepatocellular carcinoma. Liver Int 2005;25:261-265   DOI   PUBMED   ScienceOn
49 Taki Y, Yamaoka Y, Takayasu T, Ino K, Shimahara Y, Mori K, et al. Bone metastases of hepatocellular carcinoma after liver resection. J Surg Oncol 1992;50: 12-18   DOI   ScienceOn
50 Murakami R, Baba Y, Furusawa M, Yokoyama T, Nishimura R, Uozumi H, et al. Short communication: the value of embolization therapy in painful osseous metastases from hepatocellular carcinomas; comparative study with radiation therapy. Br J Radiol 1996;69:1042-1044   DOI   ScienceOn
51 Choi HJ, Cho BC, Sohn JH, Shin SJ, Kim SH, Kim JH, et al. Brain metastases from hepatocellular carcinoma: prognostic factors and outcome: brain metastasis from HCC. J Neurooncol 2009;91:307-313   DOI   ScienceOn
52 Chiba T, Tokuuye K, Matsuzaki Y, Sugahara S, Chuganji Y, Kagei K, et al. Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients. Clin Cancer Res 2005;11:3799-3805   DOI   ScienceOn
53 Fong Y KN, Lawrence T. Cancer of the liver and biliary tree. In: De Vita VT, Hellman S, Rosenberg S, eds. Cancer: Principles and Practices of Oncology 2001;1: 1162-1204
54 Di Maio M, De Maio E, Perrone F, Pignata S, Daniele B. Hepatocellular carcinoma: systemic treatments. J Clin Gastroenterol 2002;35(Suppl 2):S109-S114   DOI   ScienceOn
55 Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-390   DOI   ScienceOn
56 Shim JH, Park JW, Choi JI, Park BJ, Kim CM. Practical efficacy of sorafenib monotherapy for advanced hepatocellular carcinoma patients in a Hepatitis B virus-endemic area. J Cancer Res Clin Oncol 2009;135: 617-625   DOI   ScienceOn
57 Loomba R, Rowley A, Wesley R, Liang TJ, Hoofnagle JH, Pucino F, et al. Systematic review: the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy. Ann Intern Med 2008;148:519-528   DOI   PUBMED   ScienceOn
58 Lalazar G, Rund D, Shouval D. Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol 2007;136: 699-712   DOI   ScienceOn
59 Mindikoglu AL, Regev A, Schiff ER. Hepatitis B virus reactivation after cytotoxic chemotherapy: the disease and its prevention. Clin Gastroenterol Hepatol 2006;4:1076-1081   DOI   ScienceOn
60 Jang JW, Choi JY, Bae SH, Yoon SK, Chang UI, Kim CW, et al. A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemolipiodolization. Hepatology 2006;43:233-240   DOI   ScienceOn
61 Mazzaferro V, Romito R, Schiavo M, Mariani L, Camerini T, Bhoori S, et al. Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis. Hepatology 2006;44:1543-1554   DOI   ScienceOn
62 Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response totreatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-216   DOI   ScienceOn
63 Walzer N, Kulik LM. Hepatocellular carcinoma: latest developments. Curr Opin Gastroenterol 2008;24:312-319   DOI   ScienceOn
64 Lam VW, Ng KK, Chok KS, Cheung TT, Yuen J, Tung H, et al. Risk factors and prognostic factors of local recurrence after radiofrequency ablation of hepatocellular carcinoma. J Am Coll Surg 2008;207:20-29   DOI   ScienceOn
65 Hori T, Nagata K, Hasuike S, Onaga M, Motoda M, Moriuchi A, et al. Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation. J Gastroenterol 2003; 38:977-981   DOI   ScienceOn
66 Kim YS, Rhim H, Cho OK, Koh BH, Kim Y. Intrahepatic recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: analysis of the pattern and risk factors. Eur J Radiol 2006;59:432-441   DOI   ScienceOn
67 Kuvshinoff BW, Ota DM. Radiofrequency ablation of liver tumors: influence of technique and tumor size. Surgery 2002;132:605-611   DOI   ScienceOn
68 Ghobrial RM, Freise CE, Trotter JF, Tong L, Ojo AO, Fair JH, et al. Donor morbidity after living donation for liver transplantation. Gastroenterology 2008:135:468-476   DOI   PUBMED   ScienceOn
69 Kim do Y, Paik YH, Ahn SH, Youn YJ, Choi JW, Kim JK, et al. PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection. Oncology 2007;72(Suppl 1):52-57   ScienceOn
70 Suh KS, Cho EH, Lee HW, Shin WY, Yi NJ, Lee KU. Liver transplantation for hepatocellular carcinoma in patients who do not meet the Milan criteria. Dig Dis 2007;25:329-333   DOI   ScienceOn
71 Shim SJ, Seong J, Han KH, Chon CY, Suh CO, Lee JT. Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma. Liver Int 2005;25:1189-1196   DOI   PUBMED   ScienceOn
72 Yamada K, Izaki K, Sugimoto K, Mayahara H, Morita Y, Yoden E, et al. Prospective trial of combined transcatheter arterial chemoembolization and three- dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2003;57:113-119   DOI   PUBMED   ScienceOn
73 Yoon SM, Kim JH, Choi EK, Ahn SD, Lee SW, Yi BY. Radioresponse of hepatocellular carcinoma: treatment of lymph node metastasis. Cancer Res Treat 2004;36:79-84   DOI   ScienceOn
74 Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007;45:507-539
75 Chen DS, Sung JL, Sheu JC, Lai MY, How SW, Hsu HC, et al. Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 1984;86:1404-1409   PUBMED   ScienceOn
76 Nakamura S, Nouso K, Sakaguchi K, Ito YM, Ohashi Y, Kobayashi Y, et al. Sensitivity and specificity of desgamma- carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. Am J Gastroenterol 2006;101:2038-2043   DOI   ScienceOn
77 Makuuchi M, Kokudo N, Arii S, Futagawa S,Kaneko S, Kawasaki S, et al. Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan. Hepatol Res 2008;38:37-51   DOI   ScienceOn
78 Suh KS. Systematic hepatectomy for small hepatocellular carcinoma in Korea. J Hepatobiliary Pancreat Surg 2005;12: 365-370   DOI   PUBMED   ScienceOn
79 Samuel M, Chow PK, Chan Shih-Yen E, Machin D, Soo KC. Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma. Cochrane Database Syst Rev 2009:CD001199
80 Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol 2009;10:35-43   DOI   ScienceOn
81 Hawkins MA, Dawson LA. Radiation therapy for hepatocellular carcinoma: from palliation to cure. Cancer 2006;106:1653-1663   DOI   ScienceOn
82 Zeng ZC, Fan J, Tang ZY, Zhou J, Qin LX, Wang JH, et al. A comparison of treatment combinations with and without radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombus. Int J Radiat Oncol Biol Phys 2005;61:432-443   DOI   PUBMED   ScienceOn
83 Lohe F, Angele MK, Gerbes AL, Lohrs U, Jauch KW, Schauer RJ. Tumour size is an important predictor for the outcome after liver transplantation for hepatocellular carcinoma. Eur J Surg Oncol 2005;31:994-999   DOI   ScienceOn
84 Huang JF, Wang LY, Lin ZY, Chen SC, Hsieh MY, Chuang WL, et al. Incidence and clinical outcome of icteric type hepatocellular carcinoma. J Gastroenterol Hepatol 2002;17:190-195   DOI   ScienceOn
85 Koneru B, Teperman LW, Manzarbeitia C, Facciuto M, Cho K, Reich D, et al. A multicenter evaluation of utility of chest computed tomography and bone scans in liver transplant candidates with stages I and II hepatoma. Ann Surg 2005;241:622-628   DOI   ScienceOn
86 Kneteman NM, Oberholzer J, Al Saghier M, Meeberg GA,Blitz M, Ma MM, et al. Sirolimus-based immunosuppressionfor liver transplantation in the presence ofextended criteria for hepatocellular carcinoma. LiverTranspl 2004;10:1301-1311   DOI   ScienceOn
87 Vilana R, Bruix J, Bru C, Ayuso C, Sole M, Rodes J.Tumor size determines the efficacy of percutaneousethanol injection for the treatment of small hepatocellularcarcinoma. Hepatology 1992;16:353-357   DOI   PUBMED
88 Yamakado K, Nakatsuka A, Takaki H, Yokoi H, Usui M, Sakurai H, et al. Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy. Radiology 2008;247:260-266   DOI   ScienceOn
89 Dawson LA, Ten Haken RK. Partial volume tolerance of the liver to radiation. Semin Radiat Oncol 2005;15:279- 283   DOI   ScienceOn
90 Shim JH, Park JW, Nam BH, Lee WJ, Kim CM. Efficacy of combination chemotherapy with capecitabine plus cisplatin in patients with unresectable hepatocellular carcinoma. Cancer Chemother Pharmacol 2009;63:459-467   DOI   ScienceOn
91 Lee KW. 1000 Cases of surgical resection for hepatocellular carcinoma. Kor J HBP Surgery postgraduate course 1998
92 Park JW. Practice guideline for diagnosis and treatment of hepatocellular carcinoma. Korean J Hepatol 2004;10:88-98   PUBMED
93 Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 2004;130:417-422   PUBMED   ScienceOn
94 Ng KK, Vanthey JN, Pawlik TM, Lauwers GY, Regimbeau JM, Belghiti J, et al. Is hepatic resection for large or multinodular hepatocelluar carcinoma justified? Results from a multi-institutional database. Ann Surg Oncol 2005;12:364-373   DOI   ScienceOn
95 Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693-699   DOI   ScienceOn
96 Hemming AW, Cattral MS, Reed AI, Van Der Werf WJ, Greig PD, Howard RJ. Liver transplantation for hepatocellular carcinoma. Ann Surg 2001;233:652-659   DOI   ScienceOn
97 Rhim H, Yoon KH, Lee JM, Cho Y, Cho JS, Kim SH, etal. Major complications after radio-frequency thermalablation of hepatic tumors: spectrum of imaging findings.Radiographics 2003;23:123-134   DOI   ScienceOn
98 Matsui O, Kadoya M, Yoshikawa J, Gabata T, TakashimaT, Demachi H. Subsegmental transcatheter arterialembolization for small hepatocellular carcinomas: localtherapeutic effect and 5-year survival rate. Cancer Chemother Pharmacol 1994;33(Suppl 1):S84-S88   DOI
99 Ganne-Carrie N, Trinchet JC. Systemic treatment of hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2004;16:275-281   PUBMED   ScienceOn
100 Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, Hong J, et al. Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg 2008;143:182-188   DOI   ScienceOn
101 Melloul E, Dondero F, Paugam-Burtz C, Bouadma L, Arnulf B, Belghiti J. Living liver donor death related to complications of myeloma. Liver Transpl 2009;15:326-329   DOI   ScienceOn
102 Marsh JW, Casavilla A, Iwatsuki S, Dvorchik I, Subotin M, Balan V, et al. Predicting the risk of tumor recurrence following transplantation for hepatocellular carcinoma. Hepatology 1997;26:1689-1691   DOI   PUBMED   ScienceOn
103 Yeo W, Chan PK, Zhong S, Ho WM, Steinberg JL, Tam JS, et al. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol 2000;62:299-307   DOI   ScienceOn
104 Hayashi K, Kumada T, Nakano S, Takeda I, Sugiyama K, Kiriyama S, et al. Usefulness of measurement of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma. Am J Gastroenterol 1999;94: 3028-3033   PUBMED
105 Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108
106 Katyal S, Oliver JH 3rd, Peterson MS, Ferris JV, Carr BS, Baron RL. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000;216:698-703   PUBMED   ScienceOn
107 Yang SH, Suh KS, Lee HW, Cho EH, Cho JY, Cho YB, et al. The role of (18)F-FDG-PET imaging for the selection of liver transplantation candidates among hepatocellular carcinoma patients. Liver Transpl 2006;12:1655-1660   DOI   ScienceOn
108 Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K,Kojiro M, et al. Results of surgical and nonsurgicaltreatment for small-sized hepatocellular carcinomas: aretrospective and nationwide survey in Japan. The LiverCancer Study Group of Japan. Hepatology 2000;32:1224-1229   DOI   ScienceOn
109 Takayasu K, Arii S, Ikai I, Omata M, Okita K, Ichida T,et al. Prospective cohort study of transarterial chemoembolizationfor unresectable hepatocellular carcinomain 8510 patients. Gastroenterology 2006;131: 461-469   DOI   PUBMED   ScienceOn
110 Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebocontrolled trial. Lancet Oncol 2009;10:25-34   DOI   ScienceOn
111 Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981;47:207-214   DOI   ScienceOn
112 Hwang S, Lee SG, Lee YJ, Sung KB, Park KM, Kim KH, et al. Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl 2006;12:920-927   DOI   ScienceOn
113 Tanaka H, Hirohashi K, Kubo S, Shuto T, Higaki I, Kinoshita H. Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function. Br J Surg 2000;87:879-882   DOI   ScienceOn
114 Roayaie S, Frischer JS, Emre SH, Fishbein TM, Sheiner PA, Sung M, et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Ann Surg 2002;235:533-539   DOI   ScienceOn
115 Graziadei IW, Sandmueller H, Waldenberger P, Koenigsrainer A, Nachbaur K, Jaschke W, et al. Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcome. Liver Transpl 2003;9:557-563   DOI   ScienceOn
116 Sala M, Llovet JM, Vilana R, Bianchi L, Sole M, AyusoC, et al. Initial response to percutaneous ablation predictssurvival in patients with hepatocellular carcinoma. Hepatology 2004;40:1352-1360   DOI   ScienceOn
117 Forner A, Vilana R, Ayuso C, Bianchi L, Sole M, Ayuso JR, et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 2008;47:97-104   DOI   ScienceOn
118 Miyayama S, Matsui O, Yamashiro M, Ryu Y, Kaito K,Ozaki K, et al. Ultraselective transcatheter arterialchemoembolization with a 2-f tip microcatheter for smallhepatocellular carcinomas: relationship between localtumor recurrence and visualization of the portal vein withiodized oil. J Vasc Interv Radiol 2007;18:365-376   DOI   ScienceOn
119 Llovet JM, Bruix J. Systematic review of randomizedtrials for unresectable hepatocellular carcinoma: Chemoembolizationimproves survival. Hepatology 2003;37:429-442   DOI   ScienceOn
120 Llovet JM, Sala M, Castells L, Suarez Y, Vilana R, Bianchi L, et al. Randomized controlled trial of interferon treatment for advanced hepatocellular carcinoma. Hepatology 2000;31:54-58   DOI   ScienceOn
121 Kim KA, Lee JS, Jung ES, Kim JY, Bae WK, Kim NH, et al. Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without HCC development. Korean J Gastroenterol 2006;48:321-326   PUBMED
122 Cho YK, Kim JK, Kim MY, Rhim H, Han JK. Systematicreview of randomized trials for hepatocellular carcinomatreated with percutaneous ablation therapies. Hepatology 2009;49:453-459   DOI   ScienceOn
123 Ikeda K, Arase Y, Saitoh S, Kobayashi M, Suzuki Y, Suzuki F, et al. Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology 2000;32:228-232   DOI   ScienceOn
124 Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-247   DOI   ScienceOn
125 Trevisani F, De NS, Rapaccini G, Farinati F, Benvegnu L, Zoli M, et al. Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience). Am J Gastroenterol 2002;97:734-744   DOI   ScienceOn
126 Kudo M, Okanoue T; Japan Society of Hepatology. Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology. Oncology 2007;72(Suppl 1): 2-15   PUBMED
127 Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005;25:133-142   DOI   ScienceOn
128 Hai L, Yong-Hong P, Yong F, Ren-Feng L. One-stage liver resection for spontaneous rupture of hepatocellular carcinoma. World J Surg 2005;29:1316-1318   DOI   ScienceOn
129 Minagawa M, Makuuchi M, Takayama T, Kokudo N. Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. Ann Surg 2003;238: 703-710   DOI   ScienceOn
130 Compagnon P, Grandadam S, Lorho R, Turlin B, CamusC, Jianrong Y, et al. Liver transplantation for hepatocellularcarcinoma without preoperative tumor biopsy.Transplantation 2008;86:1068-1076   DOI   ScienceOn
131 Hong SN, Lee SY, Choi MS, Lee JH, Koh KC, Paik SW,et al. Comparing the outcomes of radiofrequency ablationand surgery in patients with a single small hepatocellularcarcinoma and well-preserved hepatic function. J Clin Gastroenterol 2005;39:247-252   DOI   ScienceOn
132 Lupo L, Panzera P, Giannelli G, Memeo M, Gentile A,Memeo V. Single hepatocellular carcinoma ranging from3 to 5 cm: radiofrequency ablation or resection? HPB(Oxford) 2007;9:429-434   DOI   PUBMED   ScienceOn
133 Abu-Hilal M, Primrose JN, Casaril A, McPhail MJ,Pearce NW, Nicoli N. Surgical resection versus radiofrequencyablation in the treatment of small unifocalhepatocellular carcinoma. J Gastrointest Surg 2008;12:1521-1526   DOI   ScienceOn
134 Leung TW, Patt YZ, Lau WY, Ho SK, Yu SC, Chan AT, et al. Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 1999;5:1676-1681   PUBMED   ScienceOn
135 Johnson PJ. Is there a role for systemic therapy in hepatocellular carcinoma, and if so, can we assess response? Educational book, American Society of Clinical Oncology 2002
136 Lau GK, He ML, Fong DY, Bartholomeusz A, Au WY, Lie AK, et al. Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation. Hepatology 2002;36:702-709   DOI   ScienceOn
137 Yao FY, Kerlan RK Jr, Hirose R, Davern TJ 3rd, Bass NM, Feng S, et al. Excellent outcome following downstaging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis. Hepatology 2008;48:819-827   DOI   ScienceOn
138 Wu CC, Ho YZ, Ho WL, Wu TC, Liu TJ, P’eng FK. Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinoma: a reappraisal. Br J Surg 1995;82:122-126   DOI   ScienceOn
139 Wakai T, Shirai Y, Sakata J, Kaneko K, Cruz PV, Akazawa K, et al. Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinoma. Ann Surg Oncol 2007;14:1356-1365   DOI   ScienceOn
140 Choi GH, Kim DH, Kang CM, Kim KS, Choi JS, Lee WJ, et al. Prognostic factors and optimal treatment strategy for intrahepatic nodular recurrence after curative resection of hepatocellular carcinoma. Ann Surg Oncol 2008;15:618-629   DOI   ScienceOn
141 Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Radiofrequencyablation improves prognosis compared withethanol injection for hepatocellular carcinoma < or =4 cm. Gastroenterology 2004;127:1714-1723   DOI   PUBMED   ScienceOn
142 Okada S. Local ablation therapy for hepatocellular carcinoma. Semin Liver Dis 1999;19:323-328   DOI   PUBMED   ScienceOn
143 Llovet JM, Real MI, Montana X, Planas R, Coll S, AponteJ, et al. Arterial embolisation or chemoembolisationversus symptomatic treatment in patients with unresectablehepatocellular carcinoma: a randomised controlledtrial. Lancet 2002;359:1734-1739   DOI   PUBMED   ScienceOn
144 Kim TH, Kim DY, Park JW, Kim YI, Kim SH, Park HS, et al. Three-dimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable. Am J Clin Oncol 2006;29:568-575   DOI   ScienceOn
145 Georgiades CS, Hong K, D'Angelo M, Geschwind JF. Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis. J Vasc Interv Radiol 2005;16: 1653-1659   DOI   PUBMED   ScienceOn
146 De Luna W, Sze DY, Ahmed A, Ha BY, Ayoub W, Keeffe EB, et al. Transarterial chemoinfusion for hepatocellular carcinoma as downstaging therapy and a bridge toward liver transplantation. Am J Transplant 2009;9:1158-1168   DOI   ScienceOn
147 Sugawara Y, Tamura S, Makuuchi M. Living donor livertransplantation for hepatocellular carcinoma: Tokyo Universityseries. Dig Dis 2007;25:310-312   DOI   ScienceOn
148 Lai EC, Fan ST, Lo CM, Chu KM, Liu CL, Wong J.Hepatic resection for hepatocellular carcinoma. An auditof 343 patients. Ann Surg 1995;221:291-298
149 Poon RT, Tso WK, Pang RW, Ng KK, Woo R, Tai KS, et al. A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drugeluting bead. Clin Gastroenterol Hepatol 2007;5:1100-1108   DOI   ScienceOn
150 Meng MB, Cui YL, Lu Y, She B, Chen Y, Guan YS, et al. Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: a systematic review and meta-analysis. Radiother Oncol 2009;92:184-194   DOI   ScienceOn
151 Yao FY, Bass NM, Nikolai B, Davern TJ, Kerlan R, Wu V, et al. Liver transplantation for hepatocellular carcinoma: analysis of survival according to the intention-to-treat principle and dropout from the waiting list. Liver Transpl 2002;8:873-883   DOI   ScienceOn
152 Taketa K, Endo Y, Sekiya C, Tanikawa K, Koji T, Taga H, et al. A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res 1993;53:5419-5423   PUBMED   ScienceOn
153 Park JW, Kim JH, Kim SK, Kang KW, Park KW, Choi JI, et al. A prospective evaluation of 18F-FDG and 11Cacetate PET/CT for detection of primary and metastatic hepatocellular carcinoma. J Nucl Med 2008;49: 1912-1921   DOI   ScienceOn
154 Trevisani F, D’Intino PE, Morselli-Labate AM, Mazzella G, Accogli E, Caraceni P, et al. Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 2001;34:570-575   DOI   ScienceOn
155 Lang H, Sotiropoulos GC, Domland M, Fruhauf NR, Paul A, Husing J, et al. Liver resection for hepatocellular carcinoma in non-cirrhotic liver without underlying viral hepatitis. Br J Surg 2005;92:198-202   DOI   ScienceOn
156 An M, Park JW, Shin JA, Choi JI, Kim TH, Kim SH, et al. The adverse effect of indirectly diagnosed portal hypertension on the complications and prognosis after hepatic resection of hepatocellular carcinoma. Korean J Hepatol 2006;12:553-561   PUBMED
157 Kim IS, Lim YS, Yoon HK, Sung KB, Jang MK, Choi WB, et al. The effect of preoperative transarterial chemoembolization on the patient's outcome in resectable hepatocellular carcinoma. Korean J Med 2005;69:614-621
158 Nakagawa T, Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Matsushita M, et al. Pulmonary resection for metastases from hepatocellular carcinoma: factors influencing prognosis. J Thorac Cardiovasc Surg 2006;131: 1248-1254   DOI   ScienceOn
159 de Baere T, Risse O, Kuoch V, Dromain C, Sengel C,Smayra T, et al. Adverse events during radiofrequencytreatment of 582 hepatic tumors. AJR Am J Roentgenol 2003;181:695-700   DOI   PUBMED   ScienceOn
160 Grimaldi C, Bleiberg H, Gay F, Messner M, Rougier P, Kok TC, et al. Evaluation of antiandrogen therapy in unresectable hepatocellular carcinoma: results of a European Organization for Research and Treatment of Cancer multicentric double-blind trial. J Clin Oncol 1998;16:411-417   DOI   PUBMED   ScienceOn
161 Gournay J, Tchuenbou J, Richou C, Masliah C, Lerat F,Dupas B, et al. Percutaneous ethanol injection vs.resection in patients with small single hepatocellularcarcinoma: a retrospective case-control study with costanalysis. Aliment Pharmacol Ther 2002;16:1529-1538   DOI   ScienceOn
162 Poon RT, Fan ST, Lo CM, Liu CL, Wong J. Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. Ann Surg 1999;229:216-222   DOI   ScienceOn
163 Yi NJ, Suh KS, Cho JY, Lee HW, Cho EH, Yang SH, et al. Three-quarters of right liver donors experienced postoperative complications. Liver Transpl 2007;13:797-806   DOI   ScienceOn
164 Akabayashi A, Slingsby BT, Fujita M. The first donor death after living-related liver transplantation in Japan. Transplantation 2004;77:634   PUBMED
165 Guo WJ, Yu EX, Liu LM, Li J, Chen Z, Lin JH, et al. Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma. World J Gastroenterol 2003;9:1697-1701   PUBMED   ScienceOn
166 Varela M, Real MI, Burrel M, Forner A, Sala M, Brunet M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 2007;46:474-481   DOI   ScienceOn
167 Network NCC. NCCN Clinical Practice Guidelines in Oncology - v.2.2008. Hepatobiliary Cancers
168 Kim DY, Park W, Lim DH, Lee JH, Yoo BC, Paik SW, et al. Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma. Cancer 2005;103:2419-2426   DOI   ScienceOn
169 Park YJ, Lim do H, Paik SW, Koh KC, Lee JH, Choi MS, et al. Radiation therapy for abdominal lymph node metastasis from hepatocellular carcinoma. J Gastroenterol 2006;41:1099-1106   DOI   ScienceOn
170 Nakamura N, Igaki H, Yamashita H, Shiraishi K, Tago M, Sasano N, et al. A retrospective study of radiotherapy for spinal bone metastases from hepatocellular carcinoma (HCC). Jpn J Clin Oncol 2007;37:38-43   DOI   ScienceOn
171 Park JW, Park KW, Cho SH, Park HS, Lee WJ, Lee DH, et al. Risk of hepatitis B exacerbation is low after transcatheter arterial chemoembolization therapy for patients with HBV-related hepatocellular carcinoma: report of a prospective study. Am J Gastroenterol 2005; 100:2194-2200   DOI   ScienceOn
172 Okada S, Shimada K, Yamamoto J, Takayama T, Kosuge T, Yamasaki S, et al. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 1994;106:1618-1624   DOI   PUBMED   ScienceOn
173 Jain D. Diagnosis of hepatocellular carcinoma: fine needle aspiration cytology or needle core biopsy. J Clin Gastroenterol 2002;35(Suppl 2):S101-S108   DOI   ScienceOn
174 Giardina MG, Matarazzo M, Morante R, Lucariello A, Varriale A, Guardasole V, et al. Serum alpha-L-fucosidase activity and early detection of hepatocellular carcinoma: a prospective study of patients with cirrhosis. Cancer 1998; 83:2468-2474   DOI   ScienceOn
175 Kim SH, Choi BI, Lee JY, Kim SJ, So YH, Eun HW, et al. Diagnostic accuracy of multi-/single-detector row CT and contrast-enhanced MRI in the detection of hepatocellular carcinomas meeting the milan criteria before liver transplantation. Intervirology 2008;51(Suppl 1):52-60   ScienceOn
176 Kuo SW, Chang YL, Huang PM, Hsu HH, Chen JS, Lee JM, et al. Prognostic factors for pulmonary metastasectomy in hepatocellular carcinoma. Ann Surg Oncol 2007;14: 992-997   DOI   ScienceOn
177 Schlitt HJ, Neipp M, Weimann A, Oldhafer KJ, Schmoll E, Boeker K, et al. Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol 1999;17:324-331   PUBMED   ScienceOn
178 Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma.Lancet 2003;362:1907-1917   DOI   ScienceOn
179 Livraghi T, Bolondi L, Lazzaroni S, Marin G, Morabito A,Rapaccini GL, et al. Percutaneous ethanol injection in thetreatment of hepatocellular carcinoma in cirrhosis. Astudy on 207 patients. Cancer 1992;69:925-929   DOI   ScienceOn
180 Leung TW, Tang AM, Zee B, Yu SC, Lai PB, Lau WY, et al. Factors predicting response and survival in 149 patients with unresectable hepatocellular carcinoma treated by combination cisplatin, interferon-alpha, doxorubicin and 5-fluorouracil chemotherapy. Cancer 2002;94: 421-427   DOI   ScienceOn
181 Lu DS, Raman SS, Limanond P, Aziz D, Economou J, Busuttil R, et al. Influence of large peritumoral vessels on outcome of radiofrequency ablation of liver tumors. J Vasc Interv Radiol 2003;14:1267-1274   DOI   PUBMED   ScienceOn
182 Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, et al. Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 1995;108:768-775   DOI   ScienceOn
183 Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, SolbiatiL, Gazelle GS. Small hepatocellular carcinoma: treatmentwith radio-frequency ablation versus ethanol injection.Radiology 1999;210:655-661   DOI   PUBMED   ScienceOn
184 Bush DA, Hillebrand DJ, Slater JM, Slater JD. High-dose proton beam radiotherapy of hepatocellular carcinoma: preliminary results of a phase II trial. Gastroenterology 2004;127(Suppl 1):S189-S193   DOI
185 Kawashima M, Furuse J, Nishio T, Konishi M, Ishii H, Kinoshita T, et al. Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol 2005;23:1839-1846   DOI   ScienceOn
186 Cha CH, Ruo L, Fong Y, Jarnagin WR, Shia J, Blumgart LH, et al. Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation. Ann Surg 2003;238:315-321   PUBMED   ScienceOn
187 Poon RT, Fan ST, Lo CM, Ng IO, Liu CL, Lam CM, et al. Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 2001;234:63-70   DOI   ScienceOn
188 Makuuchi M, Sano K. The surgical approach to HCC: our progress and results in Japan. Liver Transpl 2004;10(Suppl 1):S46-S52   DOI   ScienceOn
189 Sheth H, Javed SS, Hilson AJ, Buscombe JR, Davidson BR. Radioisotope bone scans in the preoperative staging of hepatopancreatobiliary cancer. Br J Surg 2005;92:203-207   DOI   ScienceOn
190 Ellsmere J, Kane R, Grinbaum R, Edwards M, Schneider B, Jones D. Intraoperative ultrasonography during planned liver resections: why are we still performing it? Surg Endosc 2007;21:1280-1283   DOI   ScienceOn
191 Lee HS, Kim JS, Choi IJ, Chung JW, Park JH, KimCY. The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. A prospective controlled study. Cancer 1997;79:2087-2094   DOI   ScienceOn
192 Maddala YK, Stadheim L, Andrews JC, Burgart LJ, Rosen CB, Kremers WK, et al. Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization. Liver Transpl 2004;10:449-455   DOI   ScienceOn
193 Brunello F, Veltri A, Carucci P, Pagano E, Ciccone G,Moretto P, et al. Radiofrequency ablation versus ethanolinjection for early hepatocellular carcinoma: a randomizedcontrolled trial. Scand J Gastroenterol 2008;43:727-735   DOI   ScienceOn
194 Camma C, Schepis F, Orlando A, Albanese M, Shahied L, Trevisani F, et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology 2002;224:47-54   DOI   PUBMED   ScienceOn
195 Kim JH, Park JW, Kim TH, Koh DW, Lee WJ, Kim CM. Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2007;69:813-819   DOI   PUBMED   ScienceOn
196 Park W, Lim DH, Paik SW, Koh KC, Choi MS, Park CK, et al. Local radiotherapy for patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2005;61:1143-1150   PUBMED   ScienceOn
197 Dawson LA, McGinn CJ, Lawrence TS. Conformal chemoradiation for primary and metastatic liver malignancies. Semin Surg Oncol 2003;21:249-255   DOI   ScienceOn
198 Kubo S, Nishiguchi S, Hamba H, Hirohashi K, Tanaka H, Shuto T, et al. Reactivation of viral replication after liver resection in patients infected with hepatitis B virus. Ann Surg 2001;233:139-145   DOI   ScienceOn
199 Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003;38:200-207   PUBMED
200 Shetty K, Timmins K, Brensinger C, Furth EE, Rattan S, Sun W, et al. Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome. Liver Transpl 2004;10:911-918   DOI   ScienceOn
201 Yoon SK. Recent advances in tumor markers of human hepatocellular carcinoma. Intervirology 2008;51(Suppl 1):34-41   DOI   ScienceOn
202 Kim MJ, Bae KW, Seo PJ, Jeong IK, Kim JH, Lee BH, et al. Optimal cut-off value of PIVKA-II for diagnosis of hepatocellular carcinoma: using ROC curve. Korean J Hepatol 2006;12:404-411   PUBMED
203 Ministry for Health and Welfare, National Cancer Center. Annual report of cancer incidence and survivalin Korea. 2003
204 Farges O, Belghiti J, Kianmanesh R, Regimbeau JM, Santoro R, Vilgrain V, et al. Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 2003;237:208-217   DOI   ScienceOn
205 Suh KS, Yi NJ. Liver transplantation for hepatocellular carcinoma. Korean J Hepatol 2006;12:493-506   PUBMED
206 Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 2008;48(Suppl 1):S20-S37
207 Woo HY, Jang JW, Choi JY,You CR, Jeong SW, Bae SH, et al. Living donor liver transplantation in hepatocellular carcinoma beyond the Milan criteria. Liver Int 2008;28:1120-1128   DOI   PUBMED   ScienceOn
208 Yang SH, Suh KS, Lee HW, Cho EH, Cho JY, Cho YB, et al. A revised scoring system utilizing serum alphafetoprotein levels to expand candidates for living donor transplantation in hepatocellular carcinoma. Surgery 2007; 141:598-609   DOI   ScienceOn
209 Schwartz M. Liver transplantation for hepatocellular carcinoma.Gastroenterology 2004;127(Suppl 1):S268-S276   DOI   ScienceOn
210 Nagamatsu H, Itano S, Nagaoka S, Akiyoshi J, Matsugaki S, Kurogi J, et al. Prophylactic lamivudine administration prevents exacerbation of liver damage in HBe antigen positive patients with hepatocellular carcinoma undergoing transhepatic arterial infusion chemotherapy. Am J Gastroenterol 2004;99:2369-2375   DOI   ScienceOn
211 KONOS. Annual report. www.konos.go.kr. 2007.
212 Hwang S, Lee SG, Moon DB, Ahn CS, Kim KH, Lee YJ, et al. Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma. Liver Transpl 2007;13:741-746   DOI   ScienceOn
213 Yeo W, Lam KC, Zee B, Chan PS, Mo FK, Ho WM, et al. Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Ann Oncol 2004;15:1661-1666   DOI   ScienceOn
214 Bleicher RJ, Allegra DP, Nora DT, Wood TF, Foshag LJ, Bilchik AJ. Radiofrequency ablation in 447 complex unresectable liver tumors: lessons learned. Ann Surg Oncol 2003;10:52-58   DOI   ScienceOn
215 Komorizono Y, Oketani M, Sako K, Yamasaki N, Shibatou T, Maeda M, et al. Risk factors for local recurrence of small hepatocellular carcinoma tumors after a single session, single application of percutaneous radiofrequency ablation. Cancer 2003;97:1253-1262   DOI   ScienceOn
216 Capurro M, Wanless IR, Sherman M, Deboer G, Shi W, Miyoshi E, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 2003;125:89-97   DOI   ScienceOn
217 Park JW, An M, Choi JI,Kim YI, Kim SH, Lee WJ, et al. Accuracy of clinical criteria for the diagnosis of hepatocellular carcinoma without biopsy in a Hepatitis B virusendemic area. J Cancer Res Clin Oncol 2007;133:937-943   DOI   ScienceOn
218 Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 1999;30:1434-1440   DOI
219 Shimada M, Takenaka K, Gion T, Fujiwara Y, Kajiyama K, Maeda T, et al. Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan. Gastroenterology 1996;111:720-726   DOI   ScienceOn
220 Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001;33:1394-1403   DOI   ScienceOn
221 You CR, Jang JW, Kang SH, Bae SH, Choi JY, Yoon SK, et al. Efficacy of transarterial chemolipiodolization with or without 3-dimensional conformal radiotherapy for huge HCC with portal vein tumor thrombosis. Korean J Hepatol 2007;13:378-386   DOI   ScienceOn
222 Zeng ZC, Tang ZY, Fan J, Qin LX, Ye SL, Zhou J, et al. Consideration of role of radiotherapy for lymphnode metastases in patients with HCC: retrospective analysis for prognostic factors from 125 patients. Int J Radiat Oncol Biol Phys 2005;63:1067-1076   DOI   PUBMED   ScienceOn
223 Furuse J, Ishii H, Nakachi K, Suzuki E, Shimizu S, Nakajima K. Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci 2008;99:159-165   PUBMED   ScienceOn
224 Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Randomisedcontrolled trial comparing percutaneous radiofrequencythermal ablation, percutaneous ethanol injection, andpercutaneous acetic acid injection to treat hepatocellularcarcinoma of 3 cm or less. Gut 2005;54:1151-1156   DOI   ScienceOn
225 O'Rourke N, Fielding G. Laparoscopic right hepatectomy: surgical technique. J Gastrointest Surg 2004;8:213-216   DOI   ScienceOn
226 Kwon CH, Kim DJ, Han YS, Park JB, Choi GS, Kim SJ, et al. HCC in living donor liver transplantation: can we expand the Milan criteria? Dig Dis 2007;25:313-319   DOI   ScienceOn
227 Todo S, Furukawa H; Japanese Study Group on Organ Transplantation. Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan. Ann Surg 2004;240:451-459   DOI   ScienceOn
228 Volk M, Marrero JA. Liver transplantation for hepatocellularcarcinoma: who benefits and who is harmed?Gastroenterology 2008;134:1612-1614   DOI   ScienceOn
229 Yi NJ, Suh KS, Cho JY, Kwon CH, Lee KW, Joh JW, etal. Recurrence of hepatitis B is associated with cumulativecorticosteroid dose and chemotherapy againsthepatocellular carcinoma recurrence after liver transplantation. Liver Transpl 2007;13:451-458   DOI   ScienceOn
230 Ishii H, Okada S, Nose H, Okusaka T, Yoshimori M,Takayama T, et al. Local recurrence of hepatocellularcarcinoma after percutaneous ethanol injection. Cancer 1996;77:1792-1796   DOI   ScienceOn
231 Kaizu T, Karasawa K, Tanaka Y, Matuda T, Kurosaki H, Tanaka S, et al. Radiotherapy for osseous metastases from hepatocellular carcinoma: a retrospective study of 57 patients. Am J Gastroenterol 1998;93:2167-2171   DOI   ScienceOn
232 Colli A, Fraquelli M, Casazza G, Massironi S, Colucci A, Conte D, et al. Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review. Am J Gastroenterol 2006;101:513-523   DOI   ScienceOn
233 Ministry for Health, Welfare and Family Affairs, National Cancer Center. Annual report of cancer incidence (2005) and survival (1993-2005) in Korea. 2008
234 Marrero JA, Su GL, Wei W, Emick D, Conjeevaram HS, Fontana RJ, et al. Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients. Hepatology 2003;37:1114-1121   DOI   ScienceOn
235 Krinsky GA, Lee VS, Theise ND, Weinreb JC, Morgan GR, Diflo T, et al. Transplantation for hepatocellular carcinoma and cirrhosis: sensitivity of magnetic resonance imaging. Liver Transpl 2002;8:1156-1164   DOI   ScienceOn
236 Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike Y,et al. Percutaneous radiofrequency ablation for hepatocellularcarcinoma. An analysis of 1000 cases. Cancer 2005;103:1201-1209   DOI   ScienceOn
237 Ueno S, Tanabe G, Nuruki K, Hamanoue M, Komorizono Y, Oketani M, et al. Prognostic performance of the new classification of primary liver cancer of Japan (4th edition) for patients with hepatocellular carcinoma: a validation analysis. Hepatol Res 2002;24:395-403   DOI   ScienceOn
238 Bae JH, Hong SW, Heo TG, Lee H. Characteristics and prognosis after resection for ruptured hepatocellular carcinoma. Korean J Hepatobiliary Pancreat Surg 2006; 10:37-41
239 Todo S, Furukawa H, Tada M; Japanese Liver Transplantation Study Group. Extending indication: role of living donor liver transplantation for hepatocellular carcinoma. Liver Transpl 2007;13(Suppl 2):S48-S54   DOI   ScienceOn
240 Cillo U, Vitale A, Bassanello M, Boccagni P, Brolese A, Zanus G, et al. Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Ann Surg 2004;239:150-159   DOI   ScienceOn
241 Ebara M, Okabe S, Kita K, Sugiura N, Fukuda H,Yoshikawa M, et al. Percutaneous ethanol injection forsmall hepatocellular carcinoma: therapeutic efficacy basedon 20-year observation. J Hepatol 2005;43:458-464   DOI   ScienceOn
242 CLIP Group (Cancer of the Liver Italian Programme). Tamoxifen in treatment of hepatocellular carcinoma: a randomised controlled trial. Lancet 1998;352:17-20   DOI   PUBMED   ScienceOn
243 Jang JW, Choi JY, Bae SH, Kim CW, Yoon SK, Cho SH, et al. Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma. J Hepatol 2004;41:427-435   DOI   ScienceOn
244 Agency for Healthcare Research Quality USPSTF. Ranking evidence about the effectiveness of treatments or screening
245 Matsui O. Detection and characterization of hepatocellular carcinoma by imaging. Clin Gastroenterol Hepatol 2005;3 (Suppl 2):S136-S140   DOI
246 Ferrero A, Vigano L, Polastri R. Ribero D, Lo Tesoriere R, Muratore, A, et al. Hepatectomy as treatment of choice for hepatocellular carcinoma in elderly cirrhotic patients. World J Surg 2005;29:1101-1105   DOI   ScienceOn
247 Ito T, Takada Y, Ueda M, Haga H, Maetani Y, Oike F, etal. Expansion of selection criteria for patients withhepatocellular carcinoma in living donor liver transplantation.Liver Transpl 2007;13:1637-1644   DOI   ScienceOn
248 Lee SG, Hwang S, Moon DB, Ahn CS, Kim KH, SungKB, et al. Expanded indication criteria of living donorliver transplantation for hepatocellular carcinoma at onelarge-volume center. Liver Transpl 2008;14:935-945   DOI   ScienceOn
249 Roberts JP. Tumor surveillance-what can and should be done? Screening for recurrence of hepatocellular carcinoma after liver transplantation. Liver Transpl 2005;11(Suppl 2): S45-S46   DOI
250 Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona- 2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001;35:421-430   DOI   ScienceOn
251 Yao FY, Hirose R, LaBerge JM, Davern TJ 3rd, Bass NM, Kerlan RK Jr, et al. A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation. Liver Transpl 2005;11:1505-1514   DOI   ScienceOn
252 Sarasin FP, Majno PE, Llovet JM, Bruix J, Mentha G, Hadengue A. Living donor liver transplantation for early hepatocellular carcinoma: a life-expectancy and costeffectiveness perspective. Hepatology 2001;33:1073-1079   DOI   ScienceOn
253 Lencioni RA, Allgaier HP, Cioni D, Olschewski M,Deibert P, Crocetti L, et al. Small hepatocellular carcinomain cirrhosis: randomized comparison of radiofrequencythermal ablation versus percutaneous ethanolinjection. Radiology 2003;228:235-240   DOI   ScienceOn
254 Hsu HC, Chen TY, Chiu KW, Huang EY, Leung SW, Huang YJ, et al. Three-dimensional conformal radiotherapy for the treatment of arteriovenous shunting in patients with hepatocellular carcinoma. Br J Radiol 2007;80:38-42   DOI   PUBMED   ScienceOn
255 Shah SA, Wei AC, Cleary SP, Yang I, McGilvray ID, Gallinger S, et al. Prognosis and results after resection of very large(>=10cm) hepatocelluar carcinoma. J Gastrointest Surg 2007;11:589-595   DOI   ScienceOn
256 Yuen MF, Poon RT, Lai CL, Fan ST, Lo CM, Wong KW, et al. A randomized placebo-controlled study of longacting octreotide for the treatment of advanced hepatocellular carcinoma. Hepatology 2002;36:687-691   DOI   ScienceOn
257 Horiike N, Iuchi H, Ninomiya T, Kawai K, Kumagi T, Michitaka K, et al. Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation. Oncol Rep 2002;9:1059-1062   PUBMED
258 Roayaie S, Schwartz JD, Sung MW, Emre SH, Miller CM, Gondolesi GE, et al. Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis. Liver Transpl 2004;10:534-540   DOI   ScienceOn
259 Park JW. National cancer screening program. Korean J Hepatol 2002;8(Suppl 3):S16-S19
260 Eguchi S, Kanematsu T, Arii S, Okazaki M, Okita K, Omata M, et al. Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey. Surgery 2008;143: 469-475   DOI   ScienceOn
261 Toso C, Meeberg GA, Bigam DL, Oberholzer J, ShapiroAM, Gutfreund K, et al. De novo sirolimus-basedimmunosuppression after liver transplantation for hepatocellularcarcinoma: long-term outcomes and side effects.Transplantation 2007;83:1162-1168   DOI   ScienceOn
262 Buczkowski AK, Kim PT, Ho SG, Schaeffer DF, Lee SI, Owen DA, et al. Multidisciplinary management of ruptured hepatocellular carcinoma. J Gastrointest Surg 2006;10:379-386   DOI   ScienceOn
263 Shah SA, Cleary SP, Wei AC, Yang I, Taylor BR, Hemming AW, et al. Recurrence after liver resection for hepatocellular carcinoma: risk factors, treatment, and outcomes. Surgery 2007;141:330-339   DOI   ScienceOn
264 Hwang S, Lee SG, Jung DH, Kim KH, Ha TY, Song GW. Simulation of deceased-donor liver graft allocation as UNOS status I or IIa on the current Korean setting for patients with hepatitis B virus-induced fulminant hepatic failure. Korean J Hepatobiliary Pancreat Surg 2009;13:31-36
265 Huang GT, Lee PH, Tsang YM, Lai MY, Yang PM, HuRH, et al. Percutaneous ethanol injection versus surgicalresection for the treatment of small hepatocellularcarcinoma: a prospective study. Ann Surg 2005;242:36-42   DOI   ScienceOn
266 Goin JE, Salem R, Carr BI, Dancey JE, Soulen MC, Geschwind JF, et al. Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 2005;16:205-213   DOI   PUBMED   ScienceOn
267 Kumada T, Nakano S, Takeda I, Sugiyama K, Osada T, Kiriyama S, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma. Hepatology 1997;25:87-92   DOI   ScienceOn
268 Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-649   DOI   ScienceOn
269 Marin D, Di Martino M, Guerrisi A, De Filippis G, Rossi M, Ginanni Corradini S, et al. Hepatocellular carcinoma in patients with cirrhosis: qualitative comparison of gadobenate dimeglumine-enhanced MR imaging and multiphasic 64-section CT. Radiology 2009;251:85-95   DOI   ScienceOn
270 Tanaka K, Shimada H, Matsuo K, Nagano Y, Endo I, Togo S. Intra-operative blood loss predicts complications after a second hepatectomy for malignant neoplasms. Ann Surg Oncol 2007;14:2668-2677   DOI   ScienceOn
271 Chapman WC, Majella Doyle MB, Stuart JE, Vachharajani N, Crippin JS, Anderson CD, et al. Outcomes of neoadjuvant transarterial chemoembolization to downstage hepatocellular carcinoma before liver transplantation. Ann Surg 2008;248:617-625   PUBMED   ScienceOn
272 Belghiti J, Cortes A, Abdalla EK, Regimbeau JM, Prakash K, Durand F, et al. Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg 2003;238:885-892   DOI   ScienceOn
273 Miller C, Florman S, Kim-Schluger L, Lento P, De La Garza J, Wu J, et al. Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. Liver Transpl 2004;10:1315-1319   DOI   ScienceOn
274 Mazzaferro V, Chun YS, Poon RT, Schwartz ME, Yao FY, Marsh JW, et al. Liver transplantation for hepatocellular carcinoma. Ann Surg Oncol 2008;15:1001-1007   DOI   ScienceOn
275 Shirabe K, Kanematsu T, Matsumata T, AdachiE, Akazawa K, Sugimachi K. Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses. Hepatology 1991;14:802-805   DOI   PUBMED
276 Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L,Tinelli C, et al. Sustained complete response and complicationsrates after radiofrequency ablation of very earlyhepatocellular carcinoma in cirrhosis: is resection still thetreatment of choice? Hepatology 2008;47:82-89   DOI   ScienceOn
277 Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT,et al. Randomized controlled trial of transarterial lipiodolchemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002;35:1164-1171   DOI   ScienceOn
278 Firpi RJ, Nelson DR. Management of viral hepatitis in hematologic malignancies. Blood Rev 2008;22:117-126   DOI   ScienceOn