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http://dx.doi.org/10.5667/tang.2019.0015

The regulatory effect of AST cream on atopic dermatitis-like skin disease.  

Han, Na-Ra (Department of Pharmacology, College of Korean Medicine, Kyung Hee University)
Kim, Hyung-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University)
Jeong, Hyun-Ja (Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University)
Publication Information
CELLMED / v.9, no.3, 2019 , pp. 7.1-7.4 More about this Journal
Abstract
In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.
Keywords
AST cream; histamine; IgE; atopic dermatitis;
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