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http://dx.doi.org/10.5667/tang.2014.0009

Prasaplai: An essential Thai traditional formulation for primary dysmenorrhea treatment  

Tangyuenyongwatana, Prasan (Faculty of Oriental Medicine, Rangsit University)
Gritsanapan, Wandee (Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University)
Publication Information
CELLMED / v.4, no.2, 2014 , pp. 10.1-10.8 More about this Journal
Abstract
Affecting more than half of menstruating women, dysmenorrhea is a cramp which causes abdominal or lower back pain just before or during a menstruation. In western medicine, non-steroidal anti-inflammatory drugs (NSAIDs) are normally used to treat primary dysmenorrheal symptoms. Despite their rapidity in relieving pain, NSAIDs have many serious side effects on the liver, kidney, and gastrointestinal tract. Thai traditional medicines comprise many preparations for treating dysmenorrhea, especially Prasaplai preparation which has been listed in the Thai traditional common household drug list since 2006. The use of Prasaplai was originated about 100 years ago and is still being used in the present time to treat dysmenorrhea. This review focuses on the history of the preparation, active ingredients, and biological activities especially on cyclooxygenase inhibitor, artifacts occurred in the preparation, quantitative analysis, and clinical trial of Prasaplai formulation.
Keywords
Prasaplai; Zingiber cassumunar; dysmenorrhea; non-steroidal anti-inflammatory drugs; cyclooxygenase;
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