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http://dx.doi.org/10.5667/tang.2013.0022

Anticonvulsant potential of some traditional medicinal plants  

Asif, Mohammad (Department of Pharmacy, GRD (PG) Institute of Management and Technology)
Publication Information
CELLMED / v.4, no.1, 2014 , pp. 1.1-1.13 More about this Journal
Abstract
Epilepsy has now become the most serious brain disorder. A number of synthetic antiepileptic drugs are available in practice, however their effectiveness does not grip true with the entire population suffering from epilepsy. Traditional systems of medicine are popular in developing countries and most of the population relies on traditional medicines for their primary health care need. Medicinal plants to be an important source of traditional medicines. Various plants are used for the treatment of epilepsy in traditional system of medicines and various plants are yet to be scientifically investigated. Phyto-constituents have been the basis of treatment of human diseases including epilepsy. Herbal products are extensively used for the treatment of many diseases worldwide and where allopathic fails or has severe side effects. Psycho neural drugs are also have very serious side effects like physical dependence, tolerance, deterioration of cognitive function and effect on respiratory, digestive and immune system. So the treatments through herbal medicines are widely used across the world due to their wide applicability and therapeutic efficacy with least side effects, which in turn has accelerated the research regarding natural therapy. In this review we have summarized some herbal anti-epileptics.
Keywords
anti-epileptics; convulsions; herbs; side effects;
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1 Zia A, Siddqui S, Begum S, Suria S. Studies on the constituents of the leaves of Nerium oleander on behavior pattern in mice. J Ethnopharmacol. 1995;49:33-39.   DOI   ScienceOn
2 Singh D, Goel RK. Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways. J Ethnopharmacol. 2009;123: 330-334.   DOI   ScienceOn
3 Smith MC, Bleck TP. Convulsive Disorders: toxicity of anticonvulsants. Clin Neuropharmacol. 1991;14:97-115. Sonavane, G.S., Palekar, R.C., Kasture, V.S., Kasture, S.B. Anticonvulsant and behavioural actions of Myristica fragrans seeds. Ind J Pharmacol. 2002;34:332-338.
4 Sridharan, R. Epidemiology of epilepsy. Current Science. 2002;82:664-670.
5 Sudha S, Kumaresan S, Amit A, David J, Venkataraman BV. Anti-convulsant activity of different extracts of Centella asiatica and Bacopa monnieri in animals. J Nat Remedies. 2002;2:33-41.
6 Sumathy T, Subramanian S, Govindaswamy S, Balakrishna K, Veluchamy G. Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytother Res. 2001;15:643-645.   DOI   ScienceOn
7 The Wealth of India - A Dictionary of Indian Raw materials and Industrial products. Vol. 10 (New Delhi, India: CSIR), pp. 581-585, 1995.
8 Umukoro S, Aladeokin AC. Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice. J Ethnopharmacol. 2010;127768-770.
9 Vasudevan M, Parle M. Antiamnesic potential of Murraya koenigii leaves. Phytother Res. 2009; 23:308-316.   DOI   ScienceOn
10 Visweswari G, Prasad KS, Chetan PS, Lokanatha V, Rajendra W. Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy Behav. 2010; 17:332-335.   DOI   ScienceOn
11 Vyawahare NS, Bodhankar SL. Anticonvulsant Activity of Argyreia speciosa in Mice. Indian J Pharm Sci. 2009;71:131-134.   DOI   ScienceOn
12 Rho JM, Sankar R. The pharmacologic basis of antiepileptic drug action. Epilepsia. 1999;40:1471-1483.   DOI   ScienceOn
13 Ribeiro RA, Leite JR. Nantenine alkaloid presents anticonvulsant effect on two classical animal models. Phytomedicine. 2003;10:563-568.   DOI   ScienceOn
14 Laidlaw J, Richens A, Chadwick D eds. Textbook of epilepsy. (Edinburgh, Scotland: Churchill Livingstone), pp. 495-559, 1993.
15 Rogawski M A, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553-564.   DOI   ScienceOn
16 Saini P, Kannapan N, Diwan A, Kumar P, Antil V, Sharma S, Singh S. Anticonvulsant activity of flower part of N. oderum. Inter J Pharma & Bio Sci. 2010;1:1-4.
17 Sayyah M, Mandgary A, Kamalinejad M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J Ethnopharmacol. 2002;82:105-109.   DOI   ScienceOn
18 Sayyah M, Mandgary A. Anticonvulsant effect of Ferula gummosa root extract against experimental seizures. Iran Biomed J. 2003;7:139-143.
19 Sayyah M, Valizadeh J, Kamalinejad M. Anticonvulsant activity of the leaf essential oilof Laurus nobilis against pentylenetetrazole-and maximal electroshock-induced seizures. Phytomedicine. 2002;9:212-216.   DOI   ScienceOn
20 Sayyah M, Saroukhani G, Peirovi A, Kamalinejad M. Analgesic and Anti-inflammatory Activity of the Leaf Essential oil of Lauraus nobilis Linn. Phytother Res. 2003;17:733-736.   DOI   ScienceOn
21 Silva MR, Ximenes RM, da Costa JG, Leal LK, de Lopes AA, Viana GS. Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Naunyn Schmiedeberqs Arch Pharmacol. 2010;381:415-426.   DOI   ScienceOn
22 Oraon A, Dev A, Jayaprakash V, Basu A, Pattnaik AK, Tripapthi SN, Akhtar M, Ahmad S, Swaroop S, Basu M. Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. J Ethnopharmacol. 2010;128:533-536.   DOI   ScienceOn
23 Pal D, Dutta S, Sarkar A. Evaluation of CNS activities of ethanol extract of roots and rhizomes of Cyperus rotundus in mice. Acta Pol Pharm, 2009;66:535-541.
24 Park, G., Lee, E., Lee, S. Evaluation of cytotoxic potential of Indonesian medicinal plants in cultured human cancer cells. Natural Product Sci. 2002;8:165-169.
25 Patil KS, Suresh Babu AR, Chaturvedi SC. Anti-convulsant activity of roots and barks of Calotropis gigantea Linn. J Nat Remedies. 2008;8:109-114.
26 Pedersen ME, Vestergaard HT, Stafford GI, van Staden J, Jager AK. The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex. J Ethnopharmacol. 2008;119:538-541.   DOI   ScienceOn
27 Reddy J, Gnanasekaran D, Vijay D, Ranganathan T.V. In vitro studies on anti asthmatic, analgesic and anti convulsant activities of the medicinal plant Bryonia laciniosa.Linn. Inter J Drug Disc. 2010;2:1-10   DOI
28 Pourgholami MH, Majzoob S, Javadi M, Kamalinejad M, Fanaee GHR, Sayyah M. The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. J. Ethnopharmacol. 1999;66:211-215.   DOI   ScienceOn
29 Pradhan D, Subudhi BB, Mishra P, Roul J. Anticonvulsant activity of methanolic extract of the plant beincasa hispidahispida (thunb) cogn fruits extracts. Indian Drugs. 2007;444-448.
30 Raza M, Shaheen F, Choudhary MI, Sambati S, Rafig A, Suria A, Atta-ur-Rahman, DeLorenzo R J. Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum. J Ethnopharmacol. 2001;78:73-78.   DOI   ScienceOn
31 Katiyar C, Kumar A, Bhattacharya SK, Singh RS. Ayurvedic processed seeds of Nuxvomica: neuropharmacological and chemical evaluation. Fitoterapia. 2010;81:190-195.
32 Kulkarni S, Desai S. Immunostimulant activity of inulin isolated from Saussurea lappa roots. Indian J Pharm Sci. 2001;63:292-294.
33 Kumar A, Ranu P. Anti-convulsant Activity of Benincasa hispida Fruit Methanol Extract. J Nat Remedies. 2004;4:195-198.
34 Maiha BB, Magaji MG, Yaro AH, Hamza AH, Ahmed ST, Magaji RA. Anticonvulsant Studies on Cochlospermum Tinctorium and Paullinia Pinnata Extracts in Laboratory Animals. Nig J Pharm Sci. 2009; 8:102-108.
35 Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia. 1995;36:S13-S26.   DOI   ScienceOn
36 Ngo Bum E, Dawack DL, Schmutz M, Rakotonirina A, Rakotonirina SV, Portet C, Jeker A, Olpe HR, Herrling P. Anticonvulsant activity of Mimosa pudica decoction. Fitoterapia. 2004;75:309-314.   DOI   ScienceOn
37 Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of Gingko nuts. Epilepsia. 2001;42:280-281.
38 Mohanraj R, Brodie MJ. Measuring the efficacy of antiepileptic drugs. Seizure. 2003;12:413-443.   DOI   ScienceOn
39 Muceniece R, Saleniece K, Krigere L, Rumaks J, Dzirkale Z, Mezhapuke R, Kviesis J, Mekss P, Klusa V, Schiöth HB, Dambrova M. Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors. Planta Med. 2008;74:491-496.   DOI   ScienceOn
40 Okokon JE, Nwafor PA. Antiulcer and anticonvulsant activity of Croton zambesicus. Pak J Pharm Sci. 2009;22;384-390.
41 Oliveira FA, Almeida RN, Sousa MFV, Barbosa-Filho JM, Diniz SA, Medeiros IA. Anticonvulsant properties of Nsalicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001; 68:199-202.   DOI   ScienceOn
42 Gupta YK, Sharma M, Chaudhary G. Antiepileptic activity of Panax ginseng against pentylenetetrazole induced kindling in rats. Indian J Physiol Pharmacol. 2001;45:502-506.   DOI   ScienceOn
43 Holmes GL. Critical issues in the treatment of epilepsy. Am J Hosp Pharm. 1993;50:S5-S16.
44 Hosseinzadeh H, Karimi GR, Rakhshanizadeh M. Anticonvulsant effect of Hypericum perforatum: role of nitric oxide. J Ethnopharmacol. 2005;98:207-208.   DOI   ScienceOn
45 Janahmadi M, Farajnia S, Vatanparast J, Abbasipour H, Kamalinejad M. The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization. J Ethnop harmacol. 2008;120:360-365.   DOI   ScienceOn
46 Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11:56-64.   DOI   ScienceOn
47 Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 2003;66:125-132.   DOI   ScienceOn
48 Huguenard JR. Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol. 1999;79:991-999.
49 Jawaid T, Argal S, Singh S. Botanicals and herbs: A traditional approach in treatment of epilepsy. J Pharm Res. 2011;4:1138-1140.
50 Kabir M, Iliyasu Z, Abubakar IS, Kabir ZS, Farinyaro AU. Knowledge, Attitude and Beliefs about epilepsy among adults in a northern Nigerian urban community. Annals of Afr Med. 2005;4:107-112.
51 Kasture VS, Kasture SB, Chopde CT. Anticonvulsive activity of Butea monosperma flowers in laboratory animals. Pharmacol Biochem Behav. 2002;72:965-972.   DOI   ScienceOn
52 Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii. Biomedica. 2010;30:245-250.   DOI
53 French, J.A, Kanner, A.M, Bautista, J, Abou-Khalil, B, Browne, T, Harden, C.L, Theodore, W.H, Bazil, C, Stern, J, Schachter, S.C, Bergen, D, Hirtz, D, Montouris, G.D, Nespeca, M, Gidal, B, Marks, W.J, Jr, Turk, W.R, Fischer, J.H, Bourgeois, B, Wilner, A, Faught, R.E Jr, Sachdeo, R.C, Beydoun, A, Glauser, T.A. Efficacy and tolerability of the new antiepileptic drugs i: Treatment of new onset epilepsy: Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the american academy of neurology and the american epilepsy society. Neurology. 2004;62:1252-1260.   DOI   ScienceOn
54 Gerlach AC, Krajewski JL. Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?. Pharmaceuticals. 2010;3:2884-2899.   DOI
55 Gilani AH, Aziz N, Khan MA, Shaheen F, Jabeen Q, Siddiqui BS, Herzig JW. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. J Ethnopharmacol. 2000;71:161-167.   DOI   ScienceOn
56 Gonzalez-Trujano ME, Lopez-Meraz L, Reyes-Ramírez A, Aguillon M, Martinez A. Effect of repeated administration of Annona diversifolia Saff. (ilama) extracts and palmitone on rat amygdala kindling. Epilepsy Behav. 2009;16:590-595.   DOI   ScienceOn
57 Goyal M, Nagori BP, Sasmal D. Sedative and anticonvulsant effects of an alcoholic extract of Capparis deciduas. J Nat Med. 2009;63:375-379.   DOI
58 Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V. Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice. Phytomedicine. 2009;16:295-302.   DOI   ScienceOn
59 Cockerel OC, Johnson L, Sander JWA, Hart YM, Shorvon DS. Remission of epilepsy: results from the National general Practice study of epilepsy. Lancet. 1995;346:140-144.   DOI   ScienceOn
60 Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, 1st ed. (New Delhi, India: National Institute of Science Communication), pp. 85-126, 1996.
61 Curio M, Jacone H, Perrut J, Pinto AC, Filho VF, Silva RC. Acute effect of Copaifera reticulata, Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. J Pharm Pharmacol. 2009;61:1105-1110.   DOI
62 Debnath S, Kannadasan M, Ghosh S, Ghosh NS, Chakraborty R, Sen S. Antiepileptic activity of the hydroalcoholic extract of Erythrina fusca Lour. bark against the animal models of MES, PTX and PTZ induced epileptic seizure models. Int J Chem Res. 2010;1:610.
63 Devinsky O. Cognitive and behavioral effects of antiepileptic drugs. Epilepsia. 1995;36:S46-S65.   DOI   ScienceOn
64 Dwivedi C, Smar, MW. Antiepileptic Agents-Recent Developments. Exp Opin Ther Patent. 1994;4:139-144.   DOI
65 Fisher RS, van Emde Boas W, Blume W, Elger C, Genton, P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: Definitions proposed by the international league against epilepsy (ilae) and the international bureau for epilepsy (ibe). Epilepsia. 2005;46:470-472.   DOI   ScienceOn
66 French J, Smith M, Faught E, Brown L. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 1999;52:1540-1545.   DOI   ScienceOn
67 Cardoso VF, Soncini R, Giusti-Paiva A. Anxiolytic-like effect of Sonchus oleraceus L. in mice. J Ethnopharmacol. 2009;124;325-327.   DOI   ScienceOn
68 Bum EN, Schmutz M, Meyer C, Rakotonirina A, Bopelet M, Portet C, Jeker A, Rakotonirina SV, Olpe HR, Herrling P. Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). J. Ethnopharmacol. 2001;76:145-150.   DOI   ScienceOn
69 Bum EN, Taiwe GS, Nkainsa LA, Moto FC, Seke Etet PF, Hiana IR, Bailabar T, Rouyatou, Seyni P, Rakotonirina A, Rakotonirina SV. Validation of anticonvulsant and sedative activity of six medicinal plants. Epilepsy Behav. 2009;14:454-458.   DOI   ScienceOn
70 Burkill, H.M. The Useful Plants of West Tropical Africa. 2nd ed. (London, UK: Kew Publishing), pp. 45-78, 2000.
71 Carrasco MC, Vallejo JR, Pardo-de-Santayana M, Peral D, Martín MA, Altimiras J. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009;23:1795-1796.   DOI   ScienceOn
72 Dwivedi C. Antiepileptic drugs. Am J Pharm Educ. 2001;65:197-202.
73 Chao JY, Baik KV, Jung JH, Park MH. In vitro antiinflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol. 2000;398:399-407.   DOI   ScienceOn
74 Ching FP, Omogbai EK, Otokiti IO. Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electroconvulsive models in rodents. Afr J Tradit Complement Altern Med. 2009;6:544-548.
75 Chisholm D. Cost-effectiveness of first-line antiepileptic drug treatments in the developing world: a population-level analysis. Epilepsia. 2005;46:751-759.   DOI   ScienceOn
76 Balamurugan G, Muralidharan P, Selvarajan S. Anti Epileptic Activity of Poly Herbal Extract from Indian Medicinal Plants. J Sci Res. 2009;1:153-159.
77 Chitme HR, Chandra M, Kaushik S. Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals. J Pharm Pharm Sci. 2004;7:70-75.
78 Bagheri SM, Sahebkar A, Gohari AR, Saeidnia S, Malmir M, Iranshahi M. Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. Pharm Biol. 2010;48:242-246.   DOI   ScienceOn
79 Balakrishnan S, Pandhi P, Bhargava VK. Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats. Indian J Exp Biol. 1998;36:51-54.
80 Barar, F.S.K.. Essentials of Pharmacotheraputics. (New delhi, India: S. Chand and Company Ltd. Publishers), 2004.
81 Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res. 2008;22:1660-1664.   DOI   ScienceOn
82 Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. 2004;61:1-48.   DOI   ScienceOn
83 Bialer M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs. 2006;15:637-647.   DOI   ScienceOn
84 Bienvenu E, Amabeoku GJ, Eagles PK, Scott G, Springfield EP. Anticonvulsant activity of aqueous extract of Leonotis leonurus. Phytomedicine. 2002;9:217-223.   DOI   ScienceOn
85 Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia. 1991;32:429-445.   DOI   ScienceOn
86 Birbeck G, Chomba E, Atadzhanov M, Mbewe E, Haworth A. The social and economic impact of epilepsy in Zambia: a crosssectional study. Lancet Neurol. 2007;6:39-44.   DOI   ScienceOn
87 Bodhankar SL, Vyawahare NS. A text book of pathophysiology. (India: Nirali Prakashan, Pune), 2005.
88 Bopaiah CP, Pradhan N. Central nervous system stimulatory action from the root extract of Plumbago zeylanica in rats. Phytother Res. 2001;15:153-156.   DOI   ScienceOn
89 Kavimani S, Iiango R, Madheswaran M, Jayakar B, Gupta M, Majumdar UK. Antitumor activity of plumbagin against dalton's ascitic lymphoma. Indian J Pharm Sci.1996;58:194-196.
90 Sonavane, G.S., Palekar, R.C., Kasture, V.S., Kasture, S.B. Anticonvulsant and behavioural actions of Myristica fragrans seeds. Ind J Pharmacol. 2002;34:332-338.
91 Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res. 2000;14:149-152.   DOI
92 Achliya GS, Wadodkar SG, Dorle AK. Evaluation of sedative and anticonvulsant activities of Unmadnashak Ghrita. J Ethnopharmacol. 2004;94:77-83.   DOI   ScienceOn
93 Achliya GS, Wadodkar SG, Dorley AK. Evaluation of CNS activity of Bramhi Ghrita. Ind J Pharmacol. 2005;37:33-36.   DOI   ScienceOn
94 Wahab A, Ul Haq R, Ahmed A, Khan RA, Raza M. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytother Res. 2009;23:153-158.   DOI   ScienceOn
95 Ambawade SD, Kasture VS, Kasture SB. Anticonvulsant activity of roots and rhizomes of Glycyrrhiza glabra. Indian J Pharmacol. 2002;34:251-255.
96 Amos S, Kolawole E, Akah P, Wambebe C, Gamaniel K. Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats. Phytomedicine. 2001;8:356-361.   DOI   ScienceOn
97 Arumugam S, Palanivelu A, Retnasamy G, Ramaiyan D. Study on the antiseizure activities of inner bark of Guettarda Speciosa (L.). Iran J Pharmacol & Therapeutics. 2009;8:73-76.
98 Vyawahare NS, Khandelwal AR, Batra VR, Andnikam AP. Herbal anticonvulsants. J Herbal Med & Toxicol. 2007;1; 9-14.
99 Wagh RV, Antre RV, Oswal RJ, Nimje HM. Anticonvulsant Activity: An Overview. J pharmaceutical Res and bioscientific Res. 2011;1:142-147.
100 Wang HH, Liao, JF, Chen, CF. Anticonvulsant effect of water extract of Scutellariae radix in mice. J Ethnopharmacol. 2000;73:185-190.   DOI   ScienceOn
101 Wannang NN, Anuka JA, Kwanashie HO, Gyang SS, Auta A. Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals. Afr Health Sci. 2008;8:74-79.
102 WHO. Epilepsy: aetiology, epidemiology and prognosis. Fact sheet No 165, 2001. http://www.who.int/inf-fs/en/fact165.html
103 Wickenden AD. Potassium channels as antiepileptic drug targets. Neuropharmacol. 2002;43:1055-1060.   DOI   ScienceOn
104 Yemitan OK, Adeyemi OO. CNS depressant activity of Lecaniodiscus cupanioides. Fitoterapia. 2005;76:412-418.   DOI   ScienceOn
105 Zhang Z, Lian XY, Li S, Stringer JL. Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora). Phytomedicine. 2009;16:485-493.   DOI   ScienceOn
106 Gupta M, Muzumdar UK, Chakrabrati S. CNS activities of methanolic extract of Moringa oleifera root in mice. Fitoterapia.1999;70:244-250.   DOI   ScienceOn
107 Nayak B. Ayurvedline. (Banglore, India: Geekay Printing Press), 2004.
108 Cambie RC, Ash J. Fijian Medicinal Plants. (Collingwood, Australia: CSIRO), p. 255,1994.
109 Yau J, Yaro AH, Abubakar MS, Anuka JA, Hussaini IM. Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract. J Ethnopharmacol. 2008;120:255-258.   DOI   ScienceOn
110 Taiwe GS, Moto FC, Ngoupaye GT, Nkantchoua GC, Pelanken MM, Rakotonirina SV, akotonirina A. Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. Epilepsy Behav. 2009;15:434-440.   DOI   ScienceOn
111 Gomes PB, Noronha EC, de Melo CT, Bezerra JN, Neto MA, Lino CS, Vasconcelos SM, Viana GS, de Sousa FC. Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice. J Ethnopharmacol. 2008;120:209-214.   DOI   ScienceOn
112 Amabeoku G. Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice. Hum Exp Toxicol. 2008;27:811-818.   DOI
113 Fulzele SV, Bhurchandi PM, Kanoje VM, Joshi SB, Dorle AK. Immunostimulant activity of Ashtamangal ghrita in rats. Indian J Pharmacol. 2002;34:194-197.
114 Silva FD, Silva MG, Feng D, de Freitas RM. Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice. Fitoterapia. 2011;82:255-259.   DOI   ScienceOn
115 Reza HM , Mohammad H, Golnaz E, Gholamreza S. Effect of methanolic extract of hyoscymus niger L. on the seizure induced by picritoxin in mice. Pak J Pharm Sci. 2009;22:308-312.