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http://dx.doi.org/10.5667/tang.2012.0042

Anxiolytic-like activity of leaf extract of traditionally used Indian-Mustard (Brassica juncea) in diabetic rats  

Thakur, Ajit Kumar (Neuropharmacology Research Laboratory, Department of Pharmaceutical Engineering, Indian Institute of Technology (Banaras Hindu University))
Chatterjee, Shyam Sunder (Stettiner Strasse 1, D-76138 Karlsruhe)
Kumar, Vikas (Neuropharmacology Research Laboratory, Department of Pharmaceutical Engineering, Indian Institute of Technology (Banaras Hindu University))
Publication Information
CELLMED / v.3, no.1, 2013 , pp. 7.1-7.7 More about this Journal
Abstract
Brassica juncea is a polyphenols enriched edible plant, with diverse medicinal uses of different parts of which have been mentioned in the Ayurveda. The effects of 10 daily oral doses (100, 200, and 400 mg/kg/day) of a methanolic Brassica juncea leaf extract in rat models of anxiety using nondiabetic and alloxan-diabetic rats were quantified. In all the three behavioural tests used, i.e. elevated plus maze, open field, and social interaction tests, anxiolytic-like activity of the extract was observed in the diabetic animals only. Quantitatively, the efficacy of the highest tested dose of the extract in these tests was always less than those observed after its lower ones. These observations provide further experimental evidences for the conviction that Brassica vegetables could as well be useful for combating diabetes associated mental health problems.
Keywords
Brassica juncea; anxiety; comorbidities; diabetes mellitus;
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1 Rahmatullah M, Shefa TF, Hasan L, Hossain MT, Ahmed S, Mamun AA, Islam MR, Rahman S, Chowdhury MH. A study on antinociceptive and anti-hyperglycemic activity of methanol extract of Brassica juncea (L.) Czern. leaves in mice. Adv in Nat Appl Sci. 2010;4:221-225.
2 Reagan LP. Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications. Exp Neurol. 2012;233:68-78.   DOI   ScienceOn
3 Reaven GM, Sageman WS, Swenson RS. Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency. Diabetologia. 1977;13:459-462.   DOI
4 Rohilla A, Ali S. Alloxan Induced Diabetes: Mechanisms and Effects. Int J Res Pharma Biomedical Sci. 2012;3:819-823.
5 Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiol Rev. 2010;90:859-904.   DOI   ScienceOn
6 Son TG, Camandola S, Mattson MP. Hormetic dietary phytochemicals. Neuromolecular Med. 2008;10:236-246.   DOI   ScienceOn
7 Valavala VK, Vangipurapu RK, Banam VR, Pulukurthi UMR, Turlapati NR. Effect of Mustard (Brassica juncea) leaf extract on Streptozotocin-induced Diabetic cataract in Wistar rats. J Food Biochem. 2011;35:109-124.   DOI   ScienceOn
8 Yadav SP, Vats V, Ammini AC, Grover JK. Brassica juncea (Rai) significantly prevented the development of insulin resistance in rats fed fructose-enriched diet. J Ethnopharmacol. 2004;93:113-116.   DOI   ScienceOn
9 Yoon BH, Jung JW, Lee JJ, Cho YW, Jang CG, Jin C, Oh TH, Ryu JH. Anxiolytic-like effects of sinapic acid in mice. Life Sci. 2007;81:234-240.   DOI   ScienceOn
10 Faulkner GE, Gorczynski PF, Cohn TA. Psychiatric illness and obesity: recognizing the "obesogenic" nature of an inpatient psychiatric setting. Psychiatr Serv. 2009;60:538-541.   DOI   ScienceOn
11 File SE, Hyde JR. Can social interaction be used to measure anxiety? Br J Pharmacol. 1978;62:19-24.   DOI   ScienceOn
12 Grover JK, Yadav S, Vats V. Hypoglycemic and antihyperglycemic effect of Brassica juncea diet and their effect on hepatic glycogen content and the key enzymes of carbohydrate metabolism. Mol Cell Biochem. 2002;241:95-101.   DOI   ScienceOn
13 Hamilton-West K. Psychobiological processes in health and illness. (California, USA: SAGE Publication Inc.), 2011.
14 Herzer M, Hood KK. Anxiety symptoms in adolescents with type 1 diabetes: association with blood glucose monitoring and glycaemic control. J Pediatr Psychol. 2010;35:415-425.   DOI   ScienceOn
15 Hutter N, Schnurr A, Baumeister H. Healthcare costs in patients with diabetes mellitus and comorbid mental disordersa systematic review. Diabetologia. 2010;53:2470-2479.   DOI
16 Jahangir M, Kim HK, Choi YH, Verpoorte R. Health-Affecting Compounds in Brassicaceae. Compr Rev Food Sci Food Safety. 2009;8:31-43.   DOI
17 Kumar V, Chatterjee SS. Ethnopharmacology and rational evaluation of herbal remedies. In Handbook of Ethnopharmacology, Eddouks M ed. 1st ed. (Trivandrum, India: Research Signpost Publishers), pp. 25-50, 2008.
18 Kumar V, Thakur AK, Barothia ND, Chatterjee SS. Therapeutic potentials of Brassica juncea: an overview. TANG. 2011;1:e2.   과학기술학회마을   DOI   ScienceOn
19 Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008;51:216-226.   DOI   ScienceOn
20 Malgorzata NK, Aleksander S. Changes of phenolic content in rapeseed during preliminary drying. J Oilseed Brassica. 2010;1:33-38.
21 Malvi R, Jain S, Khatri S, Patel A, Mishra S. A review on Antidiabetic medicinal plants and marketed herbal formulations. Int J Pharm Biol Arch. 2011;2:1344-1355.
22 Manohar PR, Pushpan R, Rohini S. Mustard and its uses in Ayurveda. Indian J Tradit Knowl. 2009;8:400-404.
23 Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006;106:1-28.   DOI   ScienceOn
24 Pan A, Sun Q, Okereke OI, Rexrode KM, Rubin RR, Lucas M, Willett WC, Manson JE, Hu FB. Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults. Diabetologia. 2012;55:63-72.   DOI
25 Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 1986;24:525-529.   DOI   ScienceOn
26 Pimentel GD, Micheletti TO, Pace F, Rosa JC, Santos RV, Lira FS. Gut-central nervous system axis is a target for nutritional therapies. Nutr J. 2012;11:12.   DOI   ScienceOn
27 Araujo WL, Nunes-Nesi A, Fernie AR. Fumarate: Multiple functions of a simple metabolite. Phytochemistry. 2011;72:838-843.   DOI   ScienceOn
28 Balhara YPS. Diabetes and psychiatric disorders. Indian J Endocrinol Metab. 2011;15:274-283.   DOI   ScienceOn
29 Bronstein PM. Repeated trials with the albino rat in the open field as a function of age and deprivation. J Comp Physiol Psychol. 1972;81:84-93.   DOI
30 Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP. Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal. 2010;13:1763-1811.   DOI   ScienceOn
31 Cartea ME, Fransisco M, Soengas P, Velasco P. Phenolic compounds in Brassica vegetables. Molecules. 2011;16:251-280.
32 DeKock PC, Morrison RI. The metabolism of chlorotic leaves. 2. Organic acids. Biochem J. 1958;70:272-277.   DOI
33 Chandrasekaran CV, Thiyagarajan P, Sundarajan K, Goudar KS, Deepak M. Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmColdTM). Food Chem Toxicol. 2009;47:1892-1902.   DOI   ScienceOn
34 Chatterjee SS, Kumar V. Holistic Psychopharmacology and Promiscuous Plants and Principles of Ayurveda. Am J Plant Sci. 2012;3:1015-1021.   DOI
35 Chatterjee SS, Noeldner M, Schoetz K. Use of rutin and isorhamnetin for treating depressive states and depression and other emotion disorders. Bioplanta Arzneimittel. 2005;EP1599211.
36 Diamond J. Medicine: diabetes in India. Nature. 2011;469:478-479.   DOI   ScienceOn