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http://dx.doi.org/10.5667/tang.2012.0032

Role of Curcuma longa, a traditional ayurvedic medicinal plant, in diabetes  

Ponnusamy, Sudha (Insitute of Bioinformatics and Biotechnology (IBB), University of Pune)
Zinjarde, Smita (Insitute of Bioinformatics and Biotechnology (IBB), University of Pune)
Bhargava, Shobha (Molecular Embryology Laboratory, Department of Zoology, University of Pune)
Kumara, Ameeta Ravi (Insitute of Bioinformatics and Biotechnology (IBB), University of Pune)
Publication Information
CELLMED / v.2, no.4, 2012 , pp. 31.1-31.7 More about this Journal
Abstract
Curcuma longa belongs to the family Zingiberaceae and can be found in the tropical and subtropical regions of the world. It is widely used in Asiatic countries, especially India and South East Asia where it is cultivated commercially as a condiment. Its rhizomes exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacterial, antioxidant effects, nematocidal activities, antiproliferative and antiangiogenic activities and are of pharmaceutical importance. Another relevant medicinal property exhibited by it is antidiabetic property which is reviewed here. Studies on the efficacy of crude C.longa extracts against type 2 diabetes in murine models reveal that it demonstrates a hypoglycemic effect by lowering the blood glucose levels under in vivo conditions. Clinical studies have revealed the safety of curucmin (major principle component exhibiting pharmaceutical properties from C.longa) on humans but with very low bioavailability. In view of its effective hypoglycemic effect and its low bioavailability, further studies are needed for the characterization of the bioactive principles and formulating the development of C.longa extracts as a novel anti-diabetic therapeutic agent.
Keywords
Curcuma longa; diabetes mellitus; curcuminoids; curcuminoid derivatives; glycosidases;
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1 Akram M, Uddin S, Ahmed A, Usmanghani K, Hannan A, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol-Plant Biol. 2010;55:65-70.
2 Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7.   DOI   ScienceOn
3 Ammon HP, Anazodo MI, Safayhi H, Dhawan BN, Srimal RC. Curcumin: a potent inhibitor of leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMPL). Planta Med. 1992;58:226.   DOI
4 Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7.   DOI   ScienceOn
5 Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of Curcumin: problems and promises. Mol Pharmaceutics. 2007;4:807-818.   DOI   ScienceOn
6 Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal, BB. Biological activities of curcumin and its analogues (Congeners) made by man and mother nature. Biocheml Pharmacol. 2008;76:1590-1611.   DOI
7 Anto RJ, Kuttan G, Babu KVD, Rajasekharan KN, Kuttan R. Antitumor and antioxidant activity of natural curcuminoids. Cancer Lett. 1995;94:79-83.   DOI   ScienceOn
8 Anto RJ, Kuttan G, Babu KVD, Rajasekharan KN, Kuttan R. Anti-inflammatory activity of natural and synthetic curcuminoids. Pharm Pharmacol Commun. 1998;4:103-106.
9 Araujo CAC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz, Rio de Janeiro. 2001;96:723-728.   DOI
10 Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr. 2002;57:41-52.   DOI
11 Balasubramanyam M, Koteswari AA, Kumar SR, Monickaraj SF, Maheswari JU Mohan V. Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J Biosci. 2003;28:715-72.   DOI   ScienceOn
12 Cheng AYY, Fantus IG. Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ. 2005;175:213-226.
13 Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-$\kappa B$. Nutrition. 2009;25:964-972.   DOI   ScienceOn
14 Cikrikci S, Mozioglu E, Yılmaz, H. Biological activity of curcuminoids isolated from Curcuma longa. Rec Nat Prod. 2008;2:19-24.
15 Du Z, Liu R, Shao W, Mao X, Ma L, Gu L, Huang Z, Chan, ASC. $\alpha$-Glucosidase inhibition of natural curcuminoids and curcumin analogs. Eur J Med Chem. 2006;41:213-218.   DOI
16 Gandhi P, Khan Z, Chakraverty N. Soluble curcumin: a promising oral supplement for health management. Int J Appl Biol Pharmaceut Tech. 2011;1:1-7.
17 Grover JK, Yadav S, Vats, V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81:81-100.   DOI   ScienceOn
18 Jain SK, Rains J, Croad J, Larson B, Jones K. Curcumin supplementation lowers TNF-$\alpha$, IL-6, IL-8, and MCP-1 Secretion in high glucose-treated cultured monocytes and blood levels of TNF-$\alpha$, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxidants & Redox Signaling. 2009;11:241-249.   DOI
19 Kuttan R, Bhanumathy P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 1985;29:197-202.   DOI   ScienceOn
20 Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, Kawada T, Nakagawa K, Kitahara M. Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol Pharm Bull. 2005;28:937-939.   DOI   ScienceOn
21 Lekshmi PC, Arimboor R, Raghu KG, Menon AN. Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects. Nat Prod Res. 2011;Oct 6. [Epub ahead of print].
22 Lekshmi PC, Arimboor R, Indulekha PS, Menon AN. Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. Int J Food Sci Nutr. 2012;Mar 5. [Epub ahead of print].
23 Luna B, Pharm D, Feinglos MN. Oral agents in the management of type 2 diabetes mellitus. Am Fam Physician. 2001;63:1747-1756.
24 Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci. 2006;78:2081-2087.   DOI
25 Nishiyama T, Mae T, Kishida H, Tsukagawa M, mimaki Y, Kuroda M, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara, M. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005;53:959-963.   DOI   ScienceOn
26 Pari L, Murugan P. Changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods Hum Nutr. 2007;62:25-29.   DOI
27 Petnual P, Sangvanich P, Karnchanatat A. A lectin from the rhizomes of turmeric (Curcuma longa L.) and its antifungal, antibacterial, and $\alpha$-glucosidase inhibitory activities. Food Sci Biotechnol. 2010;19:907-916.   DOI
28 Roughley PJ, Whiting DA. Experiments in the biosynthesis of curcumin. J Chem Soc. 1973;20:2379-2388.
29 Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine. 2000;7:303-308.   DOI
30 Roth GN, Chandra A, Nair MG. Novel bioactivities of Curcuma longa constituents. J Nat Prod. 1998;61:542-545.   DOI   ScienceOn
31 Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007;28:1765-1773.   DOI
32 Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol. 1995;47:59-67.   DOI
33 Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006;33:940-945.   DOI   ScienceOn
34 Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann NY. Acad Sci. 2005;1056:206-217.   DOI
35 Sivabalan S, Anuradha CV. A comparative study on the antioxidant and glucose-lowering effects of curcumin and bisdemethoxycurcumin analog through in vitro assays. Int J Pharmacol. 2010;6:664-669.   DOI
36 Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr. 2005;56:399-414.   DOI   ScienceOn
37 Srinivasan K, Ramarao P. Animal models in type 2 diabetes research: An overview. Indian J Med Res. 2007;125:451-472.
38 Sudha P, Zinjarde S, Bhargava S, Rajamohanan PR, Kumar AR. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic $\alpha$-amylase, a target for type-2 diabetes. Food Chem. 2012;135:2638-2642.   DOI
39 Srinivasan A, Menon VP, Periaswamy V, Rajasekaran K. Protection of pancreatic $\beta$-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. J Pharm Pharmaceut Sci. 2003;6:327-333.
40 Sudha P, Ravindran R, Zinjarde S, Bhargava S, Kumar AR. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. Evid base Compl Alternative Med. 2011;2011:Article ID 515647,1-10.
41 Suresh BP, Srinivasan K. Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mol Cell Biochem. 1995;152:13-21.
42 Suresh BP, Srinivasan K. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol Cell Biochem. 1997;175:49-57.   DOI
43 Suresh BP, Srinivasan K. Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats. Mol Cell Biochem. 1998;181:87-96.   DOI
44 Usharani P Mateen AA, Naidu MUR, Raju YSN, Naval C. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. 2008;9:243-250.   DOI
45 Verma S, Singh SP. Current and future status of herbal medicines. Vet World. 2008;1:347-350.
46 World Health Organization (WHO), Diabetes programme 2006, http//www.who.Int/diabetes/en/
47 Wickenberg J, Ingemansson SL, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9:1-5.   DOI