Browse > Article
http://dx.doi.org/10.5667/tang.2011.0002

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model  

Oh, Hyun-A (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University)
Ryu, Jae-Gyu (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University)
Cha, Wung-Seok (Department of Korean Medical History, College of Oriental Medicine, Kyung Hee University)
Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University)
Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
Publication Information
CELLMED / v.2, no.1, 2012 , pp. 9.1-9.13 More about this Journal
Abstract
Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVA-sensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, I${\kappa}$B kinase-${\beta}$, nuclear factor-${\kappa}$B/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.
Keywords
Jeechool-Whan; allergic rhinitis; macrophage inflammatory protein-2; intercellular adhesion molecule-1; receptor interacting protein; caspase-1;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Cha WS, Oh JH, Park HJ, Ahn SW, Hong SY, Kim NI. Historical difference between traditional Korean medicine and traditional Chinese medicine. Neurol Res. 2007;29 Suppl 1:S5-9.
2 Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002;416:190-194.   DOI   ScienceOn
3 Choi K, Lee J, Yoo J, Lee E, Koh B, Lee. Sasang constitutional types can act as a risk factor for insulin resistance. J.Diabetes Res Clin Pract. 2011;91:57-60.   DOI   ScienceOn
4 Eum HA, Lee WY, Kim SH, Kim JY, Park SW, Lee JS, Choi SM, Pyo S, Kang MJ, Min YD, et al. Anti-inflammatory activity of CML-1: an herbal formulation. Am J Chin Med. 2005;33:29-40.   DOI   ScienceOn
5 Fuentes-Beltran A, Montes-Vizuet R, Valencia-Maqueda E, Negrete-García MC, García-Cruz Mde L, Teran LM. Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients. Clin Exp Allergy. 2009;39:491-499.   DOI   ScienceOn
6 Fukui N, Honda K, Ito E, Ishikawa K. Peroxisome proliferator-activated receptor gamma negatively regulates allergic rhinitis in mice. Allergol Int. 2009;58:247-253.   DOI   ScienceOn
7 Albelda SM. Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol. 1991;4:195-203.   DOI   ScienceOn
8 Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347:911-920.   DOI   ScienceOn
9 Bournazou I, Mackenzie KJ, Duffin R, Rossi AG, Gregory CD. Inhibition of eosinophil migration by lactoferrin. Immunol Cell Biol. 2010;88:220-223.   DOI   ScienceOn
10 Yazdi AS, Guarda G, 'Ombrain MC, Drexler SK. Drexler SK. Inflammatory caspases in innate immunity and inflammation. J Innate Immun. 2010;2(3):228-237.   DOI   ScienceOn
11 Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J allergy Clin Immunol. 2001;108:2-8.
12 Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH. Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. Biochem Biophys Res Commun. 2002;299:652-658.   DOI   ScienceOn
13 Sato Y, Ohta S, Sakurai N, Shinoda M. Studies on chemical protectors against radiation. XXVI. Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation. Yakugaku Zasshi. 1989;109:113-118.   DOI
14 Shin TY, Kim SH, Kim SH, Kim YK, Park HJ, Chae BS, Jung HJ, Kim HM. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens. Immunopharmacol Immunotoxicol. 2000;22:489-500.   DOI   ScienceOn
15 Smith SJ, Piliponsky AM, Rosenhead F, Elchalal U, Nagler A, Levi-Schaffer F. Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells. Clin Exp Allergy. 2002;32:906-913.   DOI   ScienceOn
16 Stutz A, Golenbock DT, Latz E. Inflammasomes: too big to miss. J Clin Invest. 2009;119:3502-3511.   DOI   ScienceOn
17 Tachibana H, Kubo T, Miyase T, Tanino S, Yoshimoto M, Sano M, Yamamoto-Maeda M, Yamada K. Identification of an inhibitor for interleukin 4-induced epsilon germline transcription and antigen specific IgE production in vivo. Biochem Biophys Res Commun. 2001;280:53-60.   DOI   ScienceOn
18 Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K, Yasuda A, Natsume M, Baba S, Ichiishi E, Yoshikawa T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med. 2004;229:247-254.   DOI
19 Whitcup SM. Recent advances in ocular therapeutics. Int Ophthalmol Clin. 2006;46:1-6.
20 Tosi MF, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: Effects on neutrophils-epithelial cell adhesion. Am J Respir Cell Mol Biol. 1992;7:214-221.   DOI   ScienceOn
21 Woschnagg C, Rubin J, Venge P. Eosinophil cationic protein (ECP) is processed during secretion. J Immunol. 2009;183:3949-3954.   DOI   ScienceOn
22 Makino T, Furuta A, Fujii H, Nakagawa T, Wakushima H, Saito K, Kano Y. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol Pharm Bull. 2001;24:1206-1209.   DOI   ScienceOn
23 Marlin SD, Springer TA. Purified intercellular adhesion molecular-1 (ICAM-1) is a ligand for lymphocyte function associated antigen-1 (LFA-1). Cell. 1987;51:813-819.   DOI   ScienceOn
24 Montefort S, Holgate ST, Howarth PH. Leukocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis. Eur Respir J. 1994;6:1044-1054.
25 Montuschi P, Sala A, Dahlen SE, Folco G. Pharmacological modulation of the leukotriene pathway in allergic airway disease. Drug Discov Today. 2007;12:404-412.   DOI   ScienceOn
26 Mosmann TR, Cherwinski H, Bond MW, Giedin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348-2357.
27 Osakabe N, Yasuda A, Natsume M, Sanbongi C, Kato Y, Osawa T, Yoshikawa T. Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice. Free Radic Biol Med. 2002;33:798-806.   DOI   ScienceOn
28 Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagisawa R, Inoue K, Kato Y, Osawa T, Yoshikawa T. Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radic Biol Med. 2003;34:1060-1069.   DOI   ScienceOn
29 Park SH, Kim MG, Lee SJ, Kim JY, Chae H. Temperament and Character Profiles of Sasang Typology in an Adult Clinical Sample. Evid Based Complement Alternat Med. 2009 Nov 17. [Epub ahead of print]
30 Pawankar R, Lee KH, Nonaka M, Takizawa R. Role of mast cells and basophils in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:93-101.
31 Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC, Wewers MD. ASC directs NF-B activation by regulating receptor interaction protein-2 (RIP2) caspase-1 interactions. The journal of immunology. 2006;176:4979-4986.   DOI
32 Jeong HJ, Kim SJ, Kim HM, Um JY, Moon PD, Jun SM, Hong SH. Yulda-hanso-tang attenuates the endotoxin-induced inflammatory cytokine production in peripheral blood mononuclear cells. International Journal of Neuroscience. 2007;117(8):1149-1165.   DOI   ScienceOn
33 Jeong HJ, Moon PD, Kim SJ, Seo JU, Kang TH, Kim JJ, Kang IC, Um JY, Kim HM, Hong SH. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression. Cell Mol Life Sci. 2009;66:1309-1319.   DOI   ScienceOn
34 Jeong MY, Lee JS, Lee JD, Kim NJ, Kim JW, Lim S. A combined extract of Cinnamomi Ramulus, Anemarrhenae Rhizoma and Alpiniae Officinari Rhizoma suppresses production of nitric oxide by inhibiting NF-kappaB activation in RAW 264.7 cells. Phytother Res. 2008;22:772-777.   DOI
35 Johansson SG, Hiurihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, et al. A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56:813-824.   DOI   ScienceOn
36 Kelsall B. Getting to the guts of NOD2. Nature medicine. 2005;11:383-384.   DOI   ScienceOn
37 Lamkanfi M, Declercq W, Depuydt B. In Caspases-Their role in Cell death and cell survival (Los M, and Walczak H, ed). Landes Bioscience and Kluwer Academic, New York. 2003
38 Kim YS, Jeong HJ, Kim HM, Cho SH. Brief comparison of the mechanism of modern medicine and traditional medicine in neuronal cell death. TANG. 2011;1(1):e1.
39 Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signaling for receptors of the innate and adaptive immune systems. Nature. 2002;416:194-199.   DOI   ScienceOn
40 Kubo M, Ma S, Wu J, Matsuda H. Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex. Biol Pharm Bull. 1996;19:1041-1045.   DOI   ScienceOn
41 Lee SS, Won TB, Kim JW, Rhee CS, Lee CH, Hong SC, Min YG. Effects of Dexamethasone on the Expression of Transforming Growth Factor-b in the Mouse Model of Allergic Rhinitis. Laryngoscope. 2007;117:1323-1328.   DOI   ScienceOn
42 Grzegorczyk J, Kowalski ML, Pilat A, Iwaszkiewicz J. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis. Mediators Inflamm. 2002;11:225-233.   DOI   ScienceOn
43 Gupta S, Feng L, Yoshimura T, Redick J, Fu SM., Rose CE. Intra-alveolar macrophage-inflammation peptide 2 induces rapid neutrophil localization in the lung. Am J Respir Cell Mol Biol. 1996;15:656-663.   DOI   ScienceOn
44 Guzman J, Izumi T, Nagai S, Costabel U. ICAM-1 and integrin expression on isolated human alveolar type II pneumocytes. Eur Respir. 1994;7:736-739.   DOI   ScienceOn
45 Hellings PW, Fokkens WJ. Allergic rhinitis and its impact on otorhinolaryngology. Allergy. 2006;61:656-664.   DOI   ScienceOn
46 Howarth PH. Allergic and nonallergic rhinitis. In: Middleton E, Reed C, Ellis E, Adkinson N, Yunginger J, Busse W, eds. Allergy, Principles and Practice, vol. 2, Allergy, Principles and Practice. 6th ed. Philadelphia: Mosby. 2003;391-410.
47 Hirota RJ, Roger NN, Nakamura H, Song HS, Sawamura M, Suganuma N. Anti-inflammatory Effects of Limonene from Yuzu (Citrus junos Tanaka) Essential Oil on Eosinophils. J Food Sci. 2010;75:87-92.   DOI
48 Hong MH, Kim JH, Bae HS, Lee NY, Shin YC, Kim SH, Ko SG. Atractylodes japonica Koidzumi Inhibits the Production of Proinflammatory Cytokines through Inhibition of the NF-${\kappa}$B/I${\kappa}$B Signal Pathway in HMC-1 Human Mast Cells. Arch Pharm Res. 2010;33:843-851.   DOI
49 Hosomi N, Fukai K, Nakanishi T, Funaki S, Ishii M. Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome. Br J Dermatol. 2008;159:744-746.
50 Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Nunez G. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 2000;275:27823-27831.
51 Martinon F. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 2005;26:447-454.   DOI   ScienceOn
52 Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, et al. World Health Organization; GA (2) LEN; Allergen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA (2) LEN and Allergen). Allergy. 2008;86:8-160.
53 Calderon E, Lockey RF. A possible role for adhesion molecules in asthma. J Allergy Clin Immunol. 1992;90:852-865.   DOI
54 Chang ML, Yang LL, Chang DM, Kuo SY, Chu SJ. The influence of Chinese traditional medicine on the production and activity of interleukin 1 (IL-1). Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1993;26:15-24.