[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5667/tang.2011.0016

Role of tea catechins in prevention of aging and age-related disorders

Khanna, Arjun (Amity Institute of Biotechnology, Amity University)
Maurya, Pawan Kumar (Amity Institute of Biotechnology, Amity University)

Publication Information

CELLMED / v.2, no.1, 2012 , pp. 2.1-2.11 More about this Journal

Abstract

Tea polyphenols especially catechins have long been studied for their antioxidant and radical scavenging properties. Scientists throughout the world have investigated the usefulness of the regular green tea consumption in several disease conditions. In-vitro and in-vivo experiments on catechins especially epigallocatechingallate have revealed a significant role in many ways. Reactive oxygen species have been increasingly implicated in the pathogenesis of many diseases and important biological processes. Toxic effects of these oxidants, commonly referred to as oxidative stress, can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Oxidative stress has been related to aging and age related disorders. It is found that in a wide variety of pathological processes, including cancer, atherosclerosis, neurological degeneration, Alzheimer's disease, ageing and autoimmune disorders, oxidative stress has its implications. Catechins have been reported to be useful in combating aging and age related disorders like cancer, cardiovascular disorders and neurodegenerative diseases. In this mini review we will discuss such studies done across the globe.

Keywords

tea catechins; aging; oxidative stress; age-related disorders;

Citations & Related Records

Reference

1	Dhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens. 2000;18(6):655-673. DOI ScienceOn
2	Dyer DG, Dunn JA, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, and Baynes JW. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest. 1993;91(6):2463-2469. DOI ScienceOn
3	El Bedoui J, Oak MH, Anglard P, Schini-Kerth VB. Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. Cardio Res. 2005;67(2):317-325. DOI ScienceOn
4	Erba D, Riso P, Bordoni A, Foti P, Biagi PL, Testolin G. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem. 2005;16(3): 144-149. DOI ScienceOn
5	Berletch JB, Liu C, Love WK, Andrews LG, Katiyar SK, Tollefsbol TO. Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG. J Cell Biochem. 2008;103(2):509-519. DOI ScienceOn
6	Berlett BS, Stadtman ER. Protein Oxidation in Aging, Disease, and Oxidative Stress. The J Biol Chem.1997;272(33):20313-20316. DOI ScienceOn
7	Bernardi P, Petronilli V, Di Lisa F, Forte M. A mitochondrial perspective on cell death. Trends Biochem Sci. 2001;26(2):112-117. DOI
8	Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with High-Grade Prostate Intraepithelial Neoplasia: A preliminary report from a one-year proof-of-principle study. Cancer Res. 2006;66(2):1234-1240. DOI ScienceOn
9	Bickford P, Heron C, Young DA, Gerhardt GA, De La Garza R. Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats. Neurobiol Aging.1992;13(4):475-481. DOI ScienceOn
10	West RL. An application of pre-frontal cortex function theory to cognitive aging. Psychol Bull. 1996;120(2):272-292. DOI
11	Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J. 1996;313(Pt1):17-29. DOI
12	Wolff VJ, Freshman M. Age-related reduction of the RNA content of rat cardiac muscle and cerebellum. Arch Biochem Biophys. 1961;95:181-182. DOI ScienceOn
13	Xu Y, Ho CT, Amin SG, Han C, Chung FL. Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. Cancer Res. 1992; 52(14):3875-3879.
14	Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F, Kitamoto T: Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease. J Neurochem. 2002; 82(5):1137-1147.
15	Yamane T, Nakatani H, Kikuoka N, Matsumoto H, Iwata Y, Kitao Y, Oya K, Takahashi T. Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Cancer 1996; 77(8 Suppl):1662-1667. DOI
16	Youdim KA, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radic Biol Med. 2001;30(6),583-594. DOI ScienceOn
17	Youdim MB, Stephenson G, Ben Shachar D. Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Ann N Y Acad Sci. 2004;1012:306-325. DOI ScienceOn
18	Zaveri NT. Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications. Life Sci. 2006;78(18):2073-2080. DOI ScienceOn
19	Bu-Abbas A, Clifford MN, Walker R, Ioannides C. Marked antimutagenic potential of aqueous green tea extracts: mechanism of action. Mutagenesis 1994;9(4):325-331. DOI ScienceOn
20	Bickford P. Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function. Brain Res.1993; 620(1):133-138. DOI ScienceOn
21	Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest.1991;87(2):432-438. DOI
22	Burgess ML, McCrea JC, Hedrick HL. Age-associated changes in cardiac matrix and integrins. Mech Ageing Dev. 2001;122(15):1739-1756. DOI ScienceOn
23	Cao J, Xu Y, Chen J, and Klaunig JE. Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis. Fundam Appl Toxicol. 1996;29(2):244-250. DOI ScienceOn
24	Virmani R, Avolio AP, Mergner WJ, Robinowitz M, Herderick EE, Cornhill JF, Guo SY, Liu TH, Ou DY, O'Rourke M. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis: comparison between occidental and Chinese communities. Am J Pathol.1991;139(5):1119-1129.
25	Zhang G, Miura Y, Yagasaki K. Effects of dietary powdered green tea and theanine on tumor growth and endogenous hyperlipidemia in hepatoma-bearing rats. Biosci Biotechnol Biochem. 2002;66(4):711-716. DOI ScienceOn
26	Velayutham P, Babu A, Liu D. Green Tea Catechins and Cardiovascular Health: An Update. Curr Med Chem.2008; 15(18):1840-1850. DOI ScienceOn
27	Verma S, Yeh ET. C-reactive protein and atherothrombosis-beyond a biomarker: an actual partaker of lesion formation. Am J Physiol Regul Integr Comp Physiol. 2003;285(5):R1253-256. DOI
28	Vlassara H, Bucala R, Striker L. Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Inves. 1994;70(2):138-151.
29	Wakai K, Ohno Y, Obata K, Aoki K: Prognostic significance of selected lifestyle factors in urinary bladder cancer. Jpn J Cancer Res. 1993;84(12):1223-1229. DOI
30	Wang CH, Li SH, Weisel RD, Fedak PW, Dumont AS, Szmitko P, Li RK, Mickle DA, Verma S. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation. 2003;107(13):1783-1790. DOI ScienceOn
31	Wang ZY, Huang MT, Lou YR, Xie JG, Reuhl KR, Newmark HL, Ho CT, Yang CS, Conney, AH. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carconogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice. Cancer Res. 1994;54(13):3428-3435.
32	Stangl V, Dreger H, Stangl K, Lorenz M. Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc Res. 2007;73(2):348-358. DOI ScienceOn
33	Ahmad N, Gupta S, Mukhtar H. Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys. 2000;376(2):338-346. DOI ScienceOn
34	Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Venneria E, O'Connor JM, Maiani G, Coudray C, Roussel AM. Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. Eur J Clin Nutr.2005;59(Suppl 2):S58-62. DOI
35	Arts IC, Hollman PC, Kromhout D. Chocolate as a source of tea flavonoids. Lancet 1999;354(9177):488. DOI ScienceOn
36	Wang ZY, Khan WA, Bickers DR and Mukhtar H. Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols. Carcinogenesis. 1989;10(2):411-415. DOI ScienceOn
37	Weinreb O, Mandel S, Amit T, Youdim MB. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem. 2004;15(9):506-516. DOI ScienceOn
38	Starke-Reed PE, Oliver CN. Protein oxidation and proteolysis during aging and oxidative stress. Arch Biochem Biophys. 1989; 275(2):559-567. DOI ScienceOn
39	Steinberg D, Parthasarathy S, Carew TF, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increases its atherogenicity. N Engl J Med. 1989;320(14):915-924. DOI ScienceOn
40	Subramanian N, Venkatesh P, Ganguli S, Sinkar VP. Role of polyphenol oxidase and peroxidase in the generation of black tea theaflavins. J Agric Food Chem. 1999;47(7):2571-2578. DOI ScienceOn
41	Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H, Fujiki H. Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis. 1998;19(10):1771-1776. DOI ScienceOn
42	Sugisawa A, Kimura M, Fenech M, Umegaki K. Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. Mutat Res. 2004;559(1-2):97-103. DOI
43	Sutherland BA, Rahman RM, Appleton I. Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem. 2006;17(5):291-306. DOI ScienceOn
44	Santangelo C, Vari R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita 2007;43(4):394-405.
45	Tournaire C, Croux S, Maurette MT, Beck I, Hocquaux M, Braun AM, Oliveros E. Antioxidant activity of flavonoids: Efficiency of singlet oxygen (1 ${\Delta}$ g) quenching. J Photochem Photobiol B. 1993; 19(3):205-215. DOI ScienceOn
46	Upaganlawar A, Balaraman R. Effect of vitamin E and green tea on hemodynamic, electrocardiographic and some biochemical alterations in experimentally induced myocardial infarction in rats. Eur J Integrative Med. 2010;2(3):135-141. DOI ScienceOn
47	van Acker SA, van den Berg DJ, Tromp MN, Griffioen DH, van Bennekom WP, van der Vijgh WJ. Bast A. Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med. 1996;20(3):331-342. DOI ScienceOn
48	Seeram NP, Zhang Y, Nair MG. Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. Nutr Cancer. 2003;46(1):101-106. DOI ScienceOn
49	Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer. Hum Mol Genet. 2001;10(7):677-685. DOI ScienceOn
50	Shimizu M, Deguchi A, Lim JT, Moriwaki H, Kopelovich L, Weinstein IB. (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. Clin. Cancer Res. 2005;11(7):2735-2746. DOI ScienceOn
51	Shukitt-Hale B, Lau FC, Joseph JA. Berry Fruit Supplementation and the Aging Brain. J Agric. Food Chem. 2008;56(3):636-641. DOI ScienceOn
52	Shukitt-Hale B, Mouzakis G, Joseph JA. Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp Gerontol. 1998;33(6):615-624. DOI ScienceOn
53	Song DU, Jung YD, Chay KO, Chung MA, Lee KH, Yang SY, Shin BA, Ahn BW. Effect of Drinking Green Tea on Age-Associated Accumulation of Maillard-Type Fluorescence and Carbonyl Groups in Rat Aortic and Skin Collagen. Arch Biochem Biophys. 2002;397(2):424-429. DOI ScienceOn
54	Shukitt-Hale B. The effects of aging and oxidative stress on psychomotor and cognitive behavior. Age 1999; 22(1):9-17. DOI ScienceOn
55	Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER and Floyd RA. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci USA. 1991;88(23):10540-10543. DOI ScienceOn
56	Son DJ, Cho MR, Jin YR, Kim SY, Park YH, Lee SH, Akiba S, Sato T, Yun YP. Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. Prostaglandins Leukot Essent Fatty Acids. 2004;71(1):25-31. DOI ScienceOn
57	Rizvi SI, Maurya PK. L-cysteine influx in erythrocytes as a function of human age. Rejuvenation Res. 2008;11(3):661-665. DOI ScienceOn
58	Rizvi SI, Pandey KB, Jha R, Maurya PK. Ascorbate recycling by erythrocytes during aging in humans. Rejuvenation Res. 2009;12:3-6. DOI ScienceOn
59	Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002;277(47):45518-45528. DOI
60	Ruidavets J, Teissedre P, Ferrieres J, Carando S, Bougard G, Cabanis J. Catechin in the Mediterranean diet: vegetable, fruit or wine? Atherosclerosis 2000;153(1):107-117. DOI ScienceOn
61	Sanae F, Miyaichi Y, Kizu H, Hayashi H. Effects of catechins on vascular tone in rat thoracic aorta with endothelium. Life Sci. 2002;71(21):2553-2562. DOI ScienceOn
62	Sachinidis A, Skach RA, Seul C, Ko Y, Hescheler JR, Ahn HY, Fingerle JR. Inhibition of the PDGF ${\beta}$ -receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. FASEB J. 2002; 16(8):893-895. DOI
63	Sadava D, Whitlock E, Kane SE. The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. Biochem Biophys Res Commun. 2007;360(1):233-237. DOI ScienceOn
64	Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Rice-Evans C. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys. 1995;322(2):339-346. DOI ScienceOn
65	Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD. Direct and indirect interactions between calcineurin-NFAT and MEK1- extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Mol Cell Biol. 2005;25(3):865-878. DOI ScienceOn
66	Paschka AG, Butler R, Young CY. Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer Lett.1998;130(1-2):1-7. DOI ScienceOn
67	Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comp Biochem Physiol C Toxicol Pharmacol. 2002;133(4):507-513. DOI ScienceOn
68	Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases:A review of their intracellular targets. Eur J Pharmacol. 2006;545(1):51-64. DOI ScienceOn
69	Raza H, John A. In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins. Food Chem Toxicol. 2007;45(10):1814-1820. DOI ScienceOn
70	Ramesh E, Geraldine P, Thomas PA. Regulatory effect of epigallocatechin gallate on the expression of C-reactive protein and other inflammatory markers in an experimental model of atherosclerosis. Chem Biol Interact. 2010;183(1):125-132. DOI ScienceOn
71	Reiter RJ, Guerrero JM, Garcia JJ, Acuna-Castroviejo D. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998;854:410-424. DOI
72	Riederer P, Sofic E, Rausch WD, Schmidt B, Reynolds GP, Jellinger K, Youdim MBH. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem. 1989;52(2):515-520. DOI
73	Rizvi SI, Maurya PK. Markers of oxidative stress in erythrocytes during aging in humans. Ann N Y Acad Sci. 2007;1100:373-382. DOI ScienceOn
74	Rizvi SI, Jha R, Maurya PK. Erythrocyte plasma membrane redox system in human aging. Rejuvenation Res. 2006;9:490-494.
75	Rizvi SI, Maurya PK. Alterations in antioxidant enzymes during aging in humans. Mol Biotechnol. 2007;27:58-61.
76	Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity. 2007;15(6):1473-1483. DOI ScienceOn
77	Nagata H, Takekoshi S, Takagi T, Honma T, Watanabe K. Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med.1999;24(1):1-11.
78	Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y. Influence of Drinking Green Tea on Breast Cancer Malignancy among Japanese Patients. Jpn J Cancer Res. 1998;89(3):254-261. DOI
79	Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER. Age-related changes in oxidized proteins. J Biol Chem. 1987;262(12):5488-5491.
80	Nam S, Smith DM, Dou QP. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem. 2001;276(16):13322-13330. DOI ScienceOn
81	Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem. 2003;87(1):172-181. DOI ScienceOn
82	Osada K, Takahashi M, Hoshina S, Nakamura M, Nakamura S, Sugano M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2001;128(2):153-164. DOI ScienceOn
83	Packham MA. Role of platelets in thrombosis and hemostasis. Can J Physiol Pharmacol. 1994;72(3):278-284. DOI ScienceOn
84	Pan T, Fei J, Zhou X, Jankovic J, Le W. Effects of green tea polyphenols on dopamine uptake and on MPP+-induced dopamine neuron injury. Life Sci. 2003;72(9):1073-1083. DOI ScienceOn
85	Pandey KB, Mehdi MM, Maurya PK, Rizvi SI. Plasma protein oxidation and its correlation with antioxidant potential during human aging. Dis Markers. 2010;29(1):31-36. DOI ScienceOn
86	Maurya PK, Prakash S. Intracellular uptake of (-) epicatechin by human erythrocytes as a function of human age. Phytotherapy Res. 2011;25(6):944-46. DOI ScienceOn
87	Maurya PK, Rizvi SI. Age dependent changes in glutathione-S-transferase: correlation with total total antioxidant potential and red cell intracellular glutathione. Indian J Clin Biochem. 2010;25(4):398-400. DOI ScienceOn
88	Maurya PK, Rizvi SI. Alterations in plasma nitric oxide during aging in humans. Indian J Biochem Biophys. 2009;46:130-132.
89	McDonald RJ, White NM. Parallel information processing in the water maze: evidence for independent memory systems involving dorsal striatum and hippocampus. Behav Neural Biol. 1994;61(3):260-270. DOI ScienceOn
90	Maurya PK, Rizvi SI. Protective role of tea catechins on erythrocytes subjected to oxidative stress during human aging. Nat Prod Res. 2009;23(12):1072-1079. DOI ScienceOn
91	Melov S. Animal models of oxidative stress, aging and therapeutic antioxidant interventions. Int J Biochem Cell Biol. 2002;34(11):1395-1400. DOI ScienceOn
92	Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol. 2004;24(3):703-710.
93	Miura Y, Chiba T, Miura S, Tomita I, Umegaki K, Ikeda M, Tomita T. Green tea polyphenols (flavan 3-ols) prevent oxidative modification of low density lipoproteins: An ex vivo study in humans. J Nutr Biochem. 2000;11(4):216-222. DOI ScienceOn
94	Mohan S, Radha E. Age related changes in muscle protein degradation. Mech Ageing Dev. 1978;7(2):81-87. DOI
95	Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet.1999;21(1):115-118. DOI ScienceOn
96	Mandel S, Maor G, Youdim MB: Iron and alpha-synuclein in the substantia Nigra of MPTP-treated mice: Effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate. J Mol Neurosci. 2004;24(3):401-416. DOI ScienceOn
97	Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng H, Weinreb O, Amit T, Youdim MB. Multifunctional Activities of Green Tea Catechins in Neuroprotection-Modulation of Cell Survival Genes, Iron-Dependent Oxidative Stress and PKC Signaling Pathway. Neurosignals. 2005;14(1-2):46-60. DOI ScienceOn
98	Matsumoto H, Yamane T, Inagake M, Nakatani H, Iwata Y, Takahashi T, Nishimura H, Nishino H, Nakagawa K, Miyazawa T. Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis. Cancer Lett.1996;104(2):205-209. DOI ScienceOn
99	Maridonneau I, Braquet P, Garay RP. $Na^+$ and $K^+$ transport damage induced by oxygen free radicals in human red cell membranes. J Biol Chem. 1983;258(5):3107-31013.
100	Masuda M, Suzui M, Weinstein IB. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res. 2001;7(12):4220-4229.
101	Matsuoka Y, Hasegawa H, Okuda S, Muraki T, Uruno T, Kubota K. Ameliorative effects of tea catechins on active oxygen-related nerve cell injuries. J Pharmacol Exp Ther.1995; 274(2):602-608.
102	Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Rev.1997;23(1-2):47-61. DOI
103	Maurya PK, Arora K, Sarkar S. Role of L-ascorbic acid in the stability of human erythrocytes during aging in humans. Indian J Gerontol. 2009;23:1-9.
104	Maurya PK, Kumar P, Siddiqui N, Tripathi P, Rizvi SI. Age-associated changes in erythrocyte glutathione peroxidase activity: correlation with total antioxidant potential. Indian J Biochem Biophys. 2010;47:319-321.
105	Li HL, Huang Y, Zhang C-N, Liu G, Wei YS, Wang AB, Liu YQ, Hui RT, Wei C, Williams GM, Liu DP, Liang CC. Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic Biol Med. 2006;40(10):1756-1775. DOI ScienceOn
106	Lin J, Lopez EF, Jin Y, Remmen HV, Bauch T, Han HC, Lindsey ML. Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms. Exp Gerontol. 2008;43(4):296-306. DOI ScienceOn
107	Li Q, Zhao HF, Zhang ZF, Liu ZG, Pei XR, Wang JB, Cai MY, Li Y. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade. Neuroscience. 2009; 159(4):1208-1215. DOI ScienceOn
108	Liao S, Umekita Y, Guo J, Kokontis JM, Hiipakka RA. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett. 1995;96(2):239-243. DOI ScienceOn
109	Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21(21):8370-8377.
110	Locher R, Emmanuele L, Suter PM, Vetter W, Barton M. Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. Eur J Pharmacol. 2002;434(1-2):1-7. DOI
111	Luczaj W, Waszkiewicz E, Skrzydlewska E, Roszkowska-Jakimiec W. Green tea protection against age-dependent ethanol-induced oxidative stress. J Toxicol Environ Health A. 2004;67(7):595-606. DOI ScienceOn
112	Lyu SY, Park WB. Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. Arc Pharm Res. 2005;28(5):573-581. DOI
113	Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727-747. DOI
114	Kumar N, Kant R, Maurya PK. Concentration-dependent effect of (-) epicatechin in hypertensive patients Phytother Res. 2010; 24(10):1433-1436. DOI ScienceOn
115	Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention. Arch Biochem Biophys. 2010;501(1):65-72. DOI ScienceOn
116	Kuroda Y, Hara Y. Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutat Res. 1999;436(1):69-97. DOI ScienceOn
117	Lakatta EG, Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease. Circulation. 2003;107(1):139-146. DOI ScienceOn
118	Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev.1993;73(2):413-467. DOI
119	Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, Prabhu S, Lambert G, Mohr S, Yang CS. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans : Formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev. 2002;11(10Pt1):1025-1032.
120	Levites Y, Amit T, Mandel S, Youdim MB. Neuroprotection and neurorescue against amyloid beta toxicity and PKC-dependent release of non-amyloidogenic soluble precursor protein by green tea polyphenol (-)epigallocatechin-3-gallate.FASEB J. 2003;17(8):952-954. DOI
121	Levites Y, Amit T, Youdim MB, Mandel S. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin-3-gallate neuroprotective action. J Biol Chem. 2002;277(34):30574-30580. DOI ScienceOn
122	Levites Y, Weinreb O, Maor G, Youdim MB, Mandel S: Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem. 2001;78(5):1073-1082. DOI ScienceOn
123	Joseph JA, Bartus RT, Clody DE, Morgan D, Finch C, Beer B, Sesack S. Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation. Neurobiol. Aging. 1983;4(4):313-319. DOI ScienceOn
124	Jain M, Hislop G, Howe G, Burch J, Ghadirian P. Alcohol and other beverage use and prostate cancer risk among Canadian men. Int J Cancer.1998;78(6):707-711. DOI ScienceOn
125	Janqueira VB, Barros SB, Chan SS, Rodriguez I, Giavarotti L, Abud RL, Deucher GP. Aging and oxidative stress. Mol Aspects Med. 2004;25(1-2):5-16. DOI ScienceOn
126	Ji BT, Chow WH, Hsing AW, McLaughlin JK, Dai Q, Gao YT, Blot WJ, Fraumeni JF Jr. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer. 1997;70(3):255-258. DOI ScienceOn
127	Jung YD, Kim MS, Shin BA, Chay KO, Ahn BW, Liu W, Bucana CD, Gallick GE and Ellis LM. EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. Br J Cancer. 2001;84(6):844-850. DOI ScienceOn
128	Kanai H, Matsuzawa Y, Kotani K, Keno Y, Kobatake T, Nagai Y, Fujioka S, Tokunaga K and Tarui S. Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertension. 1990;16(5):484-490. DOI
129	Kang WS, Lim IH, Yuk DY, Chung KH, Park JB, Yoo HS, Yun YP. Antithrombotic Activities of Green Tea Catechins and (-)-Epigallocatechin Gallate. Thromb Res. 1999;96(3):229-237. DOI ScienceOn
130	Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL and Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266(5193):2011-2115. DOI ScienceOn
131	Kluger A, Gianutsos JG, Golomb J, Ferris SH, George AE, Frannssen E, Reisberg B. Patterns of motor impairment in normal aging, mild cognitive decline, and early Alzheimer's disease. J Gerontol B Psychol Sci Soc Sci.1997;52(1):28-39.
132	Hibasami H, Komiya T, Achiwa Y, Ohnishi K, Kojima T, Nakanishi K, Akashi K, Hara Y. Induction of apoptosis in human stomach cancer cells by green tea catechins. Oncol Rep.1998;5(2):527-529.
133	Koga T, Meydani M. Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr. 2001;73(5):941-948. DOI
134	Harman D. Free-radical theory of aging. Increasing the functional life span. Ann N Y Acad Sci 1994;717:1-15. DOI ScienceOn
135	Hayakawa S, Saeki K, Sazuka M, Suzuki Y, Shoji Y, Ohta T, Kaji K, Yuo A and Isemura M. Apoptosis induction by epigallocatechin gallate involves its binding to Fas. Biochem Biophys Res Commun. 2001; 285(5):1102-1106. DOI ScienceOn
136	Hindmarch I, Rigney U, Stanley N, Quinlan P, Rycroft J, Lane J: A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality. Psychopharmacol. 2000;149(3):203-216. DOI
137	Hirose M, Akagi K, Hasegawa R, Yaono RM, Satoh T, Hara Y, Wakabayashi K, Ito N. Chemoprevention of 2-amino-1-methyl-6-phenylimidazow[4,5-b]-pyridine (PhIP).-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis 1995;16(2):217-221. DOI ScienceOn
138	Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group. A nested case-control study of stomach cancer in relation to green tea consumption in Japan. Br J Cancer. 2004;90(1):135-138. DOI ScienceOn
139	Ichikawa D, Matsui A, Imai M, Sonoda Y, Kasahara T. Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1. Biol Pharm Bull. 2004;27(9):1353-1358. DOI ScienceOn
140	Zhong L, Goldberg MS, Gao YT, Hanley JA, Parent ME, Jin F. A population-based case-control study of lung cancer and green tea consumption among women living in Shanghai, China. Epidemiology. 2001;12(6):695-700. DOI ScienceOn
141	Gao YT, McLaughlin JK, Blot WJ, Ji BT, Dai Q, Fraumeni JF Jr. Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Inst. 1994;86(11):855-858. DOI ScienceOn
142	Inagake M, Yamane T, Kitao Y, Oya K, Matsumoto H, Kikuoka N, Nakatani H, Takahashi T, Nishimura H, Iwashima A. Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage by green tea extract in rat. Jpn J Cancer Res.1995;86(11):1106-1111. DOI
143	Inal ME, Kanbak G, Sunal E. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin Chim Acta. 2001;305(1-2):75-80. DOI
144	Esterbauer H, Jurgens G, Quehenberger O, and Koller E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res.1987;28:495-509.
145	Gerlach M, Double KL, Ben-Shachar D, Zecca L, Youdim MB, Riederer P. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotox Res. 2003;5(1-2):35-44. DOI ScienceOn
146	Gokulakrisnan A, Vinayagam MM, Rahman LAA, Thirunavukkarasu C. Attenuation of cardiac oxidative stress by (-)-epigallocatechin-gallate(EGCG) in CS exposed rats. Biomed Pharmacother. 2010 Oct 23. [Epub ahead of print]
147	Gotz ME, Freyberger A, Riederer P. Oxidative stress: a role in the pathogenesis of Parkinson's disease. J Neural Transm Suppl.1990;29:241-249.
148	Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med. 1992;21(3):334-350. DOI ScienceOn
149	Gutteridge JM. Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun.1993;19(3):141-158. DOI
150	Zhou YD, Kim YP, Li XC, Baerson SR, Agarwal AK, Hodges TW, Ferreira D, Nagle DG. Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts. J Nat Prod. 2004;67(12):2063-2069. DOI ScienceOn
151	Zhu M, Gong Y, Yang Z, Ge G, Han C, Chen J. Green tea and its major components ameliorate immune dysfunction in mice bearing Lewis lung carcinoma and treated with the carcinogen NNK. Nutr Cancer. 1999;35(1):64-72. DOI ScienceOn
152	Harman D. Free radical involvement in aging. Pathophysiology and therapeutic implications. Drug Aging. 1993;3(1):60-80. DOI ScienceOn
153	Hakim IA, Harris RB, Brown S, Chow HH, Wiseman S, Agarwal S, Talbot W. Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J Nutr. 2003;133(10):3303S-3309S. DOI
154	Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys. 1986;246(2):501-514. DOI ScienceOn
155	Hammerstone JF, Lazarus SA, Schmitz HH. Procyanidin content and variation in some commonly consumed foods. J Nutr. 2000;130(8S Suppl):2086S-2092S. DOI
156	Carter HB, Epstein JI, Partin AW. Influence of age and prostate-specific antigen on the chance of curable prostate cancer among men with nonpalpable disease. Urology. 1999;53(1):126-130. DOI ScienceOn
157	Checkoway H, Powers K, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD. Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol. 2002;155(8):732-738. DOI ScienceOn
158	Choi JY, Park CS, Kim DJ, Cho MH, Jin BK, Pie JE, Chung WG. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicol. 2002;23(3):367-374. DOI ScienceOn
159	Chow HH, Hakim IA. Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacol Res. 2011;64(2):105-112
160	Cory S, Adams JM. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2(9):647-656. DOI
161	Devan BD, Goad EH, Petri HL. Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze. Neurobiol Learn Mem. 1996;66(3):305-323. DOI ScienceOn