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Usefulness of Network Pharmacology Analysis in Exploring Herbal Medicine Resources for the Treatment of Dementia  

Suin Cho (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Journal of TMJ Balancing Medicine / v.12, no.1, 2022 , pp. 7-14 More about this Journal
Abstract
Objectives: Dementia is a disease in which a person maintains a normal intellectual level during the growth period, but has acquired cognitive impairment and personality change. In this study, we tried to check whether the network pharmacology analysis method is useful in the search for herbal medicine resources for the treatment of dementia. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database is a database frequently used in Chinese medicine research. We used the TCMSP to identify herbal medicines and their molecular targets that can be used for dementia by using network pharmacology research methods. Results: It was possible to select 28 types of components that are expected to be active by applying them to the living body, and 75 types of targets that these components act on were secured. In addition, 16 kinds of drugs were identified by checking the drugs containing 28 kinds of ingredients, and it was found that Radix Salviae contained 2 kinds of the selected 28 kinds of ingredients. Conclusions: Through this study, we were able to identify ingredients, drugs, and targets that can be used for basic and clinical research on dementia.
Keywords
Dementia; Systems biology; Herbal medicine; Molecular target;
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Times Cited By KSCI : 2  (Citation Analysis)
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