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http://dx.doi.org/10.3947/ic.2010.42.3.137

IgE-Mediated Hypersensitivity Reactions to Cephalosporins  

Kim, Baek-Nam (Department of Internal Medicine1, Inje University SanggyePaik Hospital, Inje Uni versity College of Medicine)
Cho, You-Sook (Division of Allergy and Clinical Immunology, Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
Infection and chemotherapy / v.42, no.3, 2010 , pp. 137-142 More about this Journal
Abstract
Cephalosporins are commonly prescribed either orally or parenterally for the treatment of bacterial infections because of wide safety margin compared with penicillins. Skin testing with a parent cephalosporin antibiotic has routinely been performed in Korea in the fear of developing anaphylaxis after the administration of a cephalosporin although penicillins are antibiotics that most commonly induce severe or life-threatening IgE-mediated reactions (anaphylaxis). In this review, we will discuss IgE-mediated hypersensitivity reactions to cephalosporins. Immunopathogenesis of IgE-mediated hypersensitivity reaction to cephalosporins, limitations of skin testing with parent cephalosporin antibiotics, and prescription strategy of cephalosporins for patients with a history of cephalosporin or penicillin hypersensitivity was described.
Keywords
Cephalosporins; Penicillins; Hypersensitivity; Anaphylaxis;
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Times Cited By KSCI : 5  (Citation Analysis)
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