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http://dx.doi.org/10.5385/nm.2021.28.4.7

Effects of Oxygen Saturation Fluctuations on Retinopathy in Infants Younger than 30 Weeks' Gestational Age  

Jeon, Chae Woo (Department of Pediatrics, Ajou University School of Medicine)
Kim, Ji Su (Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center)
Park, Bumhee (Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center)
Lee, Jang Hoon (Department of Pediatrics, Ajou University School of Medicine)
Publication Information
Neonatal Medicine / v.28, no.1, 2021 , pp. 7-13 More about this Journal
Abstract
Purpose: To evaluate the risk factors and effects of fluctuations in oxygen saturation on the occurrence and severity of retinopathy of prematurity (ROP). Methods: From January 1, 2013 to January 31, 2020, 260 patients hospitalized in the neonatal intensive care unit of Ajou University Hospital were retrospectively analyzed. Results: Sixty-six patients (25%) were diagnosed with ROP; of them 39 required treatment. In the multivariate regression analysis of ROP severity, the odds ratio (OR) of gestational age was 0.32 (95% confidence interval [CI], 0.22 to 0.47; P<0.0001). The OR of saturation of peripheral oxygen (SpO2) fluctuations at the 4th week after birth was 1.02 (95% CI, 1.02 to 1.12; P=0.041). Conclusion: SpO2 fluctuations in premature infants younger than 30 weeks' gestational age affects ROP severity, especially at the 4th week of life.
Keywords
Retinopathy of prematurity; Risk factors; Oxygen;
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