Nonpharmacologic Pain Relief with Oral 25% Dextrose or/and Pacifier for Newborn Infants
![]() |
Kim, Min-Kyung
(Department of Pediatrics, College of Medicine, Ulsan University, Seoul Asan Medical Center)
Kim, In-Ah (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) Jung, Min-Hee (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) Han, Myung-Ki (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) Park, Kie-Young (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) Kim, Bong-Seong (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) Jin, Hyun-Seong (Department of Pediatrics, College of Medicine, Ulsan University, Gangneung Asan Medical Center) |
1 | Puchalski M, Hummel P. The reality of neonatal pain. Adv Neonatal Care 2002;2:233-44. |
2 | Anand KJ, Coskun V, Thrivikraman KV, Nemeroff CB, Plotsky PM. Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiol Behav 1999;66:627-37. DOI ScienceOn |
3 | Bhutta AT, Anand KJ. Vulnerability of the developing brain. Neuronal mechanisms. Clin Perinatol 2002;29:357-72. DOI ScienceOn |
4 | Fitzgerald M, Beggs S. The neurobiology of pain: developmental aspects. Neuroscientist 2001;7:246-57. DOI |
5 | Porter FL, Grunau RE, Anand KJ. Long-term effects of pain in infants. J Dev Behav Pediatr 1999;20:253-61. DOI |
6 | Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA 2008;300:60-70. DOI ScienceOn |
7 | Porter FL, Wolf CM, Gold J, Lotsoff D, Miller JP. Pain and pain management in newborn infants: a survey of physicians and nurses. Pediatrics 1997;100:626-32. DOI ScienceOn |
8 | Simons SH, van Dijk M, Anand KS, Roofthooft D, van Lingen RA, Tibboel D. Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates. Arch Pediatr Adolesc Med 2003;157:1058-64. DOI ScienceOn |
9 | American Academy of Pediatrics; Committee on Fetus and Newborn; Canadian Paediatric Society; Fetus and Newborn Committee. Prevention and management of pain in the neonate. An update. Adv Neonatal Care 2007;7:151-60. DOI ScienceOn |
10 | Durrmeyer X, Vutskits L, Anand KJ, Rimensberger PC. Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data. Pediatr Res 2010;67:117-27. DOI ScienceOn |
11 | Cignacco E, Hamers JP, Stoffel L, van Lingen RA, Gessler P, McDougall J, et al. The efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates. A systematic literature review. Eur J Pain 2007;11:139-52. DOI ScienceOn |
12 | Franck LS, Lawhon G. Environmental and behavioral strategies to prevent and manage neonatal pain. Semin Perinatol 1998;22:434-43. DOI ScienceOn |
13 | Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev 2004;(3):CD001069. |
14 | Blass EM, Watt LB. Suckling- and sucrose-induced analgesia in human newborns. Pain 1999;83:611-23. DOI ScienceOn |
15 | Bruck E. Sucrose as an analgesic for newborn infants. Pediatrics 1991;88:655. |
16 | Ramenghi LA, Evans DJ, Levene MI. "Sucrose analgesia": absorptive mechanism or taste perception? Arch Dis Child Fetal Neonatal Ed 1999;80:F146-7. DOI |
17 | Chermont AG, Falcao LF, de Souza Silva EH, de Cassia Xavier Balda R, Guinsburg R. Skin-to-skin contact and/or oral 25% dextrose for procedural pain relief for term newborn infants. Pediatrics 2009;124: e1101-7. DOI ScienceOn |
18 | Curtis SJ, Jou H, Ali S, Vandermeer B, Klassen T. A randomized controlled trial of sucrose and/or pacifier as analgesia for infants receiving venipuncture in a pediatric emergency department. BMC Pediatr 2007;7:27. DOI |
19 | Lawrence J, Alcock D, McGrath P, Kay J, MacMurray SB, Dulberg C. The development of a tool to assess neonatal pain. Neonatal Netw 1993;12:59-66. |
20 | Elserafy FA, Alsaedi SA, Louwrens J, Bin Sadiq B, Mersal AY. Oral sucrose and a pacifier for pain relief during simple procedures in preterm infants: a randomized controlled trial. Ann Saudi Med 2009;29:184-8. |
21 | Grunau RV, Craig KD. Pain expression in neonates: facial action and cry. Pain 1987;28:395-410. DOI ScienceOn |
22 | Stevens B, Johnston C, Petryshen P, Taddio A. Premature infant pain profile: development and initial validation. Clin J Pain 1996;12:13- 22. |
23 | Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, Beyene J, et al. Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review. Arch Dis Child 2010;95:406-13. DOI ScienceOn |
24 | Shann F. Suckling and sugar reduce pain in babies. Lancet 2007;369:721-3. DOI ScienceOn |
25 | Taddio A, Shah V, Hancock R, Smith RW, Stephens D, Atenafu E, et al. Effectiveness of sucrose analgesia in newborns undergoing painful medical procedures. CMAJ 2008;179:37-43. DOI ScienceOn |
26 | Chung YC, Cho KJ. Pain relieving effect of sucrose coating pacifier in neonates. Korean J Child Health Nurs 2005;11:356-64. |
27 | Joung KH, Cho SC. The effect of sucrose on infants during a painful procedure. Korean J Pediatr 2010;53:790-4. DOI |
28 | Kim DS, O MH, Sim JG, Kim KH, Kim MH. Study of the analgesic effect of sucrose and non-sucrose sweet substances(Aspartam, Dextrose) in full term neonates. J Korean Pediatr Soc 1999;42:650-6. |
29 | Yoon HB. Pain relieving effect of intraoral sucrose replacement in neonates. Korean J Child Health Nurs 2001;7:35-50. |
30 | Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ 1999;319:1393-7. DOI ScienceOn |
31 | Willis DM, Chabot J, Radde IC, Chance GW. Unsuspected hyperosmolality of oral solutions contributing to necrotizing enterocolitis in very-low-birth-weight infants. Pediatrics 1977;60:535-8. |
32 | Johnston CC, Filion F, Snider L, Majnemer A, Limperopoulos C, Walker CD, et al. Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks' postconceptional age. Pediatrics 2002;110:523-8. DOI ScienceOn |
33 | Abdulkader HM, Freer Y, Fleetwood-Walker SM, McIntosh N. Effect of suckling on the peripheral sensitivity of full-term newborn infants. Arch Dis Child Fetal Neonatal Ed 2007;92:F130-1. DOI |
34 | Blass E, Fitzgerald E, Kehoe P. Interactions between sucrose, pain and isolation distress. Pharmacol Biochem Behav 1987;26:483-9. DOI ScienceOn |
![]() |