Browse > Article

Nomogram of Transcutaneous Bilirubin Level after Birth Driven from a Single Center  

Han, Young-Ji (Department of Pediatrics, Sung-Ae General Hospital)
Kim, Eun-Ryoung (Department of Pediatrics, Sung-Ae General Hospital)
Lee, Myung-Sook (Department of Pediatrics, Gwang Myang Sung-Ae General Hospital)
Lee, Won-Uk (Department of Pediatrics, Gwang Myang Sung-Ae General Hospital)
Park, Su-Hwa (Department of Pediatrics, Gwang Myang Sung-Ae General Hospital)
Lee, Jung-Ju (Department of Pediatrics, College of Medicine, Chung-Ang Uninversity)
Publication Information
Neonatal Medicine / v.17, no.1, 2010 , pp. 102-108 More about this Journal
Abstract
Purpose : The goal of this study was to measure bilirubin levels over 6 hours using a transcutaneous bilirubinometer. The change in the bilirubin levels were recorded in anomogram. The natural progress of jaundice in neonates was monitored using the nomogram and cases were identified that needed further follow-up observation and treatment. Methods : The subjects of this study were 986 healthy term or near-term infants at the age of 35 weeks or older who were born at Sung-Ae General Hospital during the period from October 1, 2007 to April 30, 2009 and whose parents were both Koreans. Transcutaneous bilirubin measurements were obtained using a transcutaneous bilirubinometer (Minolta, JM-103) from 6 hours of life to discharge at intervals of 6 hours. A nomogram was derived from the obtained data and compared to the delivery method, gestational age, and feeding method. Results : Percentile graphs were drawn according to time. Based on the graphs, phototherapy was necessary in more than 90 percent of the infants between 35 and 37.6 weeks of age and in 95 percent of the infants 38 weeks and older. The mean bilirubin level at 24, 48, 72 and 96 hours after birth were compared according to the delivery method, gestational age, and feeding method. The bilirubin level in 48 hours was significantly higher in neonates born via cesarean section delivery compared to the neonates born via vaginal delivery, however the levels were not statistically different at the other hours. Conclusion : The results of this study show the nomogram derived from hour-specific transcutaneous bilirubin levels. This information can be used to predict the risk for subsequent significant hyperbilirubinemia.
Keywords
Newborn; Neonatal jaundice;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kliegman RM, Behrman RE, Jenson HB. Nelson textbook pediatrics. 17th ed. Philadelphia : WB Saunders Co, 2004:592-9.
2 Smith DW, Inguillo D, Martin D, Vreman HJ, Cohen RS, Stevenson DK. Use of noninvasive tests to predict significant jaundice in full-term infants: preliminary studies. Pediatrics 1985;75:278-80.
3 Yamauchi Y, Yamanouchi I. Clinical application of transcutaneous bilirubin measurement. Early prediction of hyperbilirubinemia. Acta Paediatr Scand 1990;79:385-90.   DOI
4 Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 1999;103:6-14.   DOI   ScienceOn
5 Maisels MJ, Kring E. Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation. Pediatrics 2006;117:1169-73.   DOI   ScienceOn
6 Canale ST, Manugian AH. Neonatal osteomyelitis of the oscalcis: a complication of repeated heel punctures. Clin Orthop Relat Res 1981;178-82.
7 An JR, Park SW, Lee HC, Kim KA, Ko SY, Lee YK, et al. Usefulness of the transcutaneous bilirubinometer in neonatal jaundice. Korean J Pediatr 2004;47:1287-92.
8 Maisels MJ, Ostrea EM Jr, Touch S, Clune SE, Cepeda E, Kring E, et al. Evaluation of a new transcutaneous bilirubinometer. Pediatrics 2004;113:1628-35.   DOI   ScienceOn
9 Harish R, Sharma DB. Transcutaneous bilirubinometry in neonates: evaluation of Minolta Air shields jaundicemeter. Indian Pediatr 1998;35:264-7.
10 Kim JW, Choi YH, Cha JK, Ryoo KY. Clinical significance of the transcutaneous bilirubinometry as screening test for prediction of the early neonatal jaundice. Korean J Perinatol 1999;10:30-9.
11 American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297-316.   DOI   ScienceOn
12 De Luca D, Romagnoli C, Tiberi E, Zuppa AA, Zecca E. Skin bilirubin nomogram for the first 96 h of life in a European normal healthy newborn population, obtained with multiwavelength transcutaneous bilirubinometry. Acta Paediatr 2008;97:146-50.   DOI   ScienceOn
13 Roh EJ, Lim JW, Cheon EJ, Ko OK. Predictive ability of predischarge transcutaneous bilirubin measurement for subsequent significant hyperbilirubinemia. J Korean Soc Neonatol 2006;13:58-67.
14 Lee SJ, Ro HS, Kum DH. A statistical observation of neonatal jaundice. J Korean Pediatr Soc 1978;21:130-5.
15 Norr KF, Nacion K. Outcomes of postpartum early discharge, 1960-1986. A comparative review. Birth 1987;14:135-41.   DOI   ScienceOn
16 Choi ES, Lee CH, Yun CK. Total serum bilirubin concentration of physiologic jaundice of healthy, full-term infants. J Korean Pediatr Soc 1980;23:111-7.
17 Maisels MJ, Kring E. Length of stay, jaundice, and hospital readmission. Pediatrics 1998;101:995-8.   DOI   ScienceOn
18 Lee KS, Perlman M, Ballantyne M, Elliott I, To T. Association between duration of neonatal hospital stay and readmission rate. J Pediatr 1995;127:758-66.   DOI   ScienceOn
19 Carty EM, Bradley CF. A randomized, controlled evaluation of early postpartum hospital discharge. Birth 1990;17:199-204.   DOI   ScienceOn
20 Waldenstrom U. Early and late discharge after hospital birth: father's involvement in infant care. Early Hum Dev 1988;17:19-28.   DOI   ScienceOn
21 Burgos AE, Schmitt SK, Stevenson DK, Phibbs CS. Readmission for neonatal jaundice in California, 1991-2000: trends and implications. Pediatrics 2008;121:e864-9.   DOI   ScienceOn
22 Sanpavat S, Nuchprayoon I, Smathakanee C, Hansuebsai R. Nomogram for prediction of the risk of neonatal hyperbilirubinemia, using transcutaneous bilirubin. J Med Assoc Thai 2005;88:1187-93.
23 Keren R, Bhutani VK, Luan X, Nihtianova S, Cnaan A, Schwartz JS. Identifying newborns at risk of significant hyperbilirubinaemia: a comparison of two recommended approaches. Arch Dis Child 2005;90:415-21.   DOI   ScienceOn
24 Newman TB, Liljestrand P, Escobar GJ. Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med 2005;159:113-9.   DOI   ScienceOn
25 Stevenson DK, Fanaroff AA, Maisels MJ, Young BW, Wong RJ, Vreman HJ, et al. Prediction of hyperbilirubinemia in near-term and term infants. Pediatrics 2001;108:31-9.   DOI   ScienceOn
26 Alpay F, Sarici SU, Tosuncuk HD, Serdar MA, Inanc N, Gokcay E. The value of first-day bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy term newborns. Pediatrics 2000;106:E16.   DOI   ScienceOn
27 Carbonell X, Botet F, Figueras J, Riu-Godo A. Prediction of hyperbilirubinaemia in the healthy term newborn. Acta Paediatr 2001;90:166-70.   DOI   ScienceOn
28 Kaplan M, Hammerman C, Feldman R, Brisk R. Predischarge bilirubin screening in glucose-6-phosphate dehydrogenase-deficient neonates. Pediatrics 2000;105:533-7.   DOI   ScienceOn
29 Grohmann K, Roser M, Rolinski B, Kadow I, Muller C, Goerlach-Graw A, et al. Bilirubin measurement for neonates: comparison of 9 frequently used methods. Pediatrics 2006;117:1174-83.   DOI   ScienceOn