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http://dx.doi.org/10.7318/KJFC/2022.37.3.248

Inhibitory Effect of Fermented Spanish Extract on Inorganic phosphate-induced Vascular Calcification in ex vivo Aortic Rings  

Lee, Sang Hee (Korea Food Research Institute)
Hong, Sun Mi (Marine Industry Research Institute for Eastrim (MIRE))
Sung, Mi Jeong (Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Culture / v.37, no.3, 2022 , pp. 248-255 More about this Journal
Abstract
Spinach (Spinacia oleracea L.), a green leafy vegetable, is well known as a functional food due to its biological activities. Vascular calcification is associated with several disease conditions including atherosclerosis, diabetes, and chronic kidney disease (CKD), and is known to raise the risk of cardiovascular diseases related morbidity and mortality. However, there are no previous studies that have investigated the effects of fermented spinach exract (FSE) against aortic and its underlying mechanisms. Therefore, this study investigated the effects and action of possible mechanisms of FSE on inorganic phosphate (PI)-induced vascular calcification in ex vivo mouse aortic rings. PI increased vascular calcification through calcium deposition in ex vivo aortic rings. FSE inhibited calcium accumulation and osteogenic key marker, runt-related transcription factor 2 (Runx2), and bone Morphogenetic Protein 2 (BMP-2) protein expression in ex vivo aortic rings. And, FSE inhibited PI-induced extracellular signal-regulated kinase (ERK) and p38 phosphorylation in ex vivo aortic rings. These results show that FSE can prevent vascular calcification which may be a crucial way for the prevention and treatment of vascular disease association with vascular calcification.
Keywords
Vascular calcification; fermented spanish extracts; calcium accumulation; osteogenic differentiation protein;
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