Browse > Article
http://dx.doi.org/10.7318/KJFC/2020.35.5.493

Study on the Correlation between Dietary Vitamin B Intakes and Clinical Indices of Type 2 Diabetes Patients  

Shim, Eugene (Department of Food and Nutrition, Soongeui Women's College)
Kwon, Ji-young (Graduate School of Human Environmental Sciences, Yonsei University)
Chung, Hae-Yun (Department of Food and Nutrition, Soongeui Women's College)
Publication Information
Journal of the Korean Society of Food Culture / v.35, no.5, 2020 , pp. 493-502 More about this Journal
Abstract
The objective of this study was to investigate the effects of dietary vitamin B intake on biomarkers related to lipid metabolism, inflammation and blood glucose control, that are important in the development of type 2 diabetes and its complications. Seventy-six adults (42 males, 34 females) were recruited from a group of diabetes patients who had visited the medical center for treatment. Data on anthropometric characteristics and dietary intake of thiamine, riboflavin, niacin, vitamin B6 and folate were collected using 24-hour diet recall and the CAN Pro 4.0 program. Also, data on clinical indices such as serum lipids, blood pressure, high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c) and homeostasis model assessment 2-insulin resistance (HOMA2-IR) were collected and analyzed for correlation with dietary vitamin B intake. Results from the dietary intake survey showed that riboflavin and folate intake (in males) and folate intake (in females) were below the Dietary Reference Intake for Koreans. Statistical analysis revealed a negative correlation between hs-CRP and dietary intake of B vitamins. Riboflavin intake was inversely associated with systolic blood pressure after adjustments for age, BMI, smoking, alcohol consumption, exercise, ingestion of diabetes mellitus medication and energy intake (p<0.05). Our results suggest that dietary vitamin B may influence inflammation and consequently may help in better management of type 2 diabetes.
Keywords
Type 2 diabetes; C-reactive protein; hemoglobin A1c; dietary vitamin B intake;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Adaikalakoteswari A, Rabbani N, Waspadji S. 2012. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia-Link to renal status, glycemic control and vascular inflammation. Diabetes Res. Clin. Pract., 95(3):415-424   DOI
2 Ahn HJ, Min KW, Cho YO. 2011. Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes. Nutr. Res. Pract., 5(1):34-39   DOI
3 Ahn J, Kim I, Lee J. 2019. Relationship of Riboflavin and Niacin with Cardiovascular Disease. Korean J. Clin. Lab. Sci., 51(4):484-494   DOI
4 Alaei-Shahmiri F, Soares M, Zhao Y, Sherriff J. 2013. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. Eur. J. Nutr., 52(7):1821-1824   DOI
5 Al-Attas O, Al-Daghri N, Alokail M, Abd-Alrahman S, Vinodson B, Sabico S. 2014. Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2. Clin. Med. Insights Endocrinol. Diabetes, 7:1-6   DOI
6 Cho N, Jang H, Park H, Cho Y. 2006. Waist circumference is the key risk factor for diabetes in Korean women with history of gestational diabetes. Diabetes Res. Clin. Pract., 71(2):177-83   DOI
7 Bose J. 1948. The Role of Vitamin B1 in the Treatment of Diabetes. Ind. Med. Gaz., 83(12):554-556
8 Brando-Lima P, Carvalho G, Santos R, Santos B, Dias-Vasconcelos N, Rocha V, Barbosa K, Pires L. 2018. Intakes of Zinc, Potassium, Calcium, and Magnesium of Individuals with Type 2 Diabetes Mellitus and the Relationship with Glycemic Control. Nutrients, 10(12):1948   DOI
9 Cao Y, Wittert G, Taylor AW, Adams R, Appleton S, Shi Z. 2017. Nutrient patterns and chronic inflammation in a cohort of community dwelling middle-aged men. Clin. Nutr., 36(4):1040-1047   DOI
10 Cumings JN. 1947. Nicotinamide and blood sugar. Br. Med. J., 2(4528):613   DOI
11 Frana C, Vianna L. 2010. Effectiveness of B Vitamins on the Control of Hypertension and Stroke Events of SHRSP Rats. J. Dietary Suppl., 7(1):71-77   DOI
12 Friedman A, Hunsicker LG, Selhub J, Bostom AG. 2004. Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy. Atherosclerosis, 172(1): 121-125   DOI
13 Hwang HJ, Choi YJ. 2019. Comparison of metabolic syndrome indicators and nutrient intakes in postmenopausal women: from the Korean National Health and Nutrition Examination Survey, 2010-2012. J. Korea Convergence Soc., 10(9):99-110
14 Friso S, Jacques PF, Wilson PWF, Rosenberg IH, Selhub J. 2001. Low Circulating Vitamin B6 Is Associated With Elevation of the Inflammation Marker C-Reactive Protein Independently of Plasma Homocysteine Levels. Circulation, 103(23):2788-2791   DOI
15 Gargari BP, Aghamohammadi V, Aliasgharzadeh A. 2011. Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes. Diabetes Res. Clin. Pract., 94(1):33-38   DOI
16 Gulliford M, Ukoumunne O. 2001. Determinants of glycated haemoglobin in the general population: associations with diet, alcohol and cigarette smoking. Eur. J. Clin. Nutr., 55:615-623   DOI
17 Hooper P, Hooper E, Hunt W, Garry P, Goodwin J. 1983. Vitamins, lipids and lipoproteins in a healthy elderly population. Int. J. Vitam. Nutr. Res., 53(4):412-419
18 Huber AM, Gershoff SN, Hegsted DM. 1964. Carbohydrate and fat metabolism and response to insulin in vitamin B6-deficient rats. J. Nutr., 82(3):371-378   DOI
19 Julius U, Fischer S. 2013. Nicotinic acid as a lipid-modifying drug - a review. Atheroscler. Suppl., 14(1):7-13   DOI
20 Kwon J, Chung H. 2013. Study on the Correlation between the Nutrient Intakes and Clinical Indices of Type 2 Diabetes Patients. Kor. J. Food Nutr., 26(4):909-918   DOI
21 Liu R, Mi B, Zhao Y, Li Q, Yan H, Dang S. 2017. Effect of B Vitamins from Diet on Hypertension. Arch. Med. Res., 48(2):187-194   DOI
22 Larkin J, Zhang F, Godfrey L, Molostvov G, Zehnder D, Rabbani N, Thornalley P. 2012. Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes. PLoS One, 7(12):e53175   DOI
23 Lee J, Lee S, Min H, Kim Y, Choi S, Kim Y. 2004. The correlation between vitamin C intake and plasma highsensitive C-reactive protein concentration. J. Korean Acad. Fam. Med., 25:314-321
24 Lee J, Park H, Kang J, Lee S, Cho Y, Song H, Kim S, Lee J. 2008. State of diabetes care in Korean adults-According to the American Diabetes Association Recommendations. J. Korean Acad. Fam. Med., 29:658-667
25 Mazur-Bialy A, Poche E. 2016. Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Molecules, 21(12):1724   DOI
26 Mahalle N, Kulkarni MV, Naik SS, Garg MK. 2014. Association of dietary factors with insulin resistance and inflammatory markers in subjects with diabetes mellitus and coronary artery disease in Indian population. J. Diabetes Complications, 28(4):536-541   DOI
27 Mahdavifard S, Nakhjavani M. 2020. Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers. Med. J. Islam. Repub. Iran, 34:47
28 Makris A, Gershoff SN. 1974. Insulin sensitivity in vitamin $B_6$-deficient rats. Effects of acute and chronic growth hormone treatment. Nutr. Metab., 16(6):337-351   DOI
29 Ministry of Health and Welfare. 2019. Korea National Health and Nutrition Examination Survey 2018
30 Ministry of Health and Welfare. 2008. Korea National Health and Nutrition Examination Survey 2007
31 Park SY, Han JS. 2005. Effects of Web-Based Nutrition Counseling on Nutrient Intake and Blood Glucose in Type II Diabetic Patients. J. Korean Soc. Food Sci. Nutr., 34(9):1398-1406   DOI
32 Plows JF, Budin F, Andersson R, Stanley JL. 2017. The effects of myo-inositol and B and D vitamin supplementation in the db/+ mouse model of gestational diabetes mellitus. Nutrients. 9(2):141   DOI
33 Rabbani N, Alam S, Riaz S, Larkin J, Akhtar M. 2009. High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. Diabetologia, 52(2):208-12   DOI
34 Tzoulaki I, Patel CJ, Okamura T, Chan Q, Elliott P. 2012. A nutrient-wide association study on blood pressure. Circulation, 126(21):2456-2464   DOI
35 Shimakawa T, Warram JH. 1993. Usual dietary intake and hemoglobin A1 level in patients with insulin-dependent diabetes. J. Am. Diet. Assoc., 93(12):1409-1412   DOI
36 Shin WY, Kim JH. 2019. Low riboflavin intake is associated with cardiometabolic risks in Korean women. Asia Pac. J. Clin. Nutr., 28(2):285-299
37 Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W. 2012. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Res. Clin. Pract., 98(1):151-158   DOI
38 Tamai Y, Wada K, Tsuji M, Nakamura K, Sahashi Y, Watanabe K, Yamamoto K, Ando K, Nagata C. 2011. Dietary intake of vitamin B12 and folic acid is associated with lower blood pressure in Japanese preschool children. Am. J. Hypertension, 24(11):1215-1221   DOI
39 Thornalley P, Babaei-Jadidi R, Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer C. 2007. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia, 50:2164-2170   DOI
40 van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB. 2002. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann. Intern. Med., 136(3):201-209   DOI
41 Waheed P, Naveed AK, Ahmed T. 2013. Thiamine deficiency and its correlation with dyslipiaemia in diabetics with microalbuminuria. J. Pak. Med. Assoc., 63(3):340-345
42 Vindedzis S, Stanton K, Sherriff J. 2008. Thiamine deficiency in diabetes-is diet relevant?. Diabetes Vasc. Dis. Res., 5(3):215   DOI