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http://dx.doi.org/10.7318/KJFC/2020.35.5.478

Protective Effect of Gryllus Bimaculatus Methanol Extract on UVB-induced Photoaging in Human Skin Fibroblasts  

Jeong, Taekyoung (Department of Food Science and Biotechnology, Chungbuk National University)
Yu, Myeongnam (Department of Food Science and Biotechnology, Chungbuk National University)
Heo, Huijin (Department of Food Science and Biotechnology, Chungbuk National University)
Yang, Jinwoo (Wheat research team, National Institute of Crop Science)
Jeong, Heonsang (Department of Food Science and Biotechnology, Chungbuk National University)
Lee, Junsoo (Department of Food Science and Biotechnology, Chungbuk National University)
Publication Information
Journal of the Korean Society of Food Culture / v.35, no.5, 2020 , pp. 478-482 More about this Journal
Abstract
We evaluated the protective effects of cricket methanol extract (CME) on ultra-violet B (UVB)-induced photoaging in human skin fibroblasts. The fibroblast cells were treated with 10, 50, and 100 ㎍/mL of CME for 24 h, and then exposed to UVB (30 mJ/㎠). CME showed a dose-dependent cytoprotective effect without any observable cytotoxicity. CME reduced UVB-induced production of reactive oxygen species (ROS) by 34.4, 34.9, 40.6% at concentrations of 10, 50, 100 ㎍/mL respectively. CME inhibited the release of matrix metalloproteinase (MMP) 1 and 3. Furthermore, CME also reduced UVB-induced collagen degradation in the fibroblast cells. Taken together, our data suggests that CME has a significant protective effect on UVB-induced photoaging of the skin. This benefit occurs through multiple mechanisms. The results also suggest a potential role for CME as an ingredient in anti-photoaging cosmetic products in the future.
Keywords
Gryllus bimaculatus; fibroblast; photoaging; collagen;
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