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http://dx.doi.org/10.7318/KJFC/2020.35.5.467

Anti-proliferative Effects of Traditional Korean Doenjang across Different Aging Periods on Cancer Cell Lines  

Yang, Hye Jeong (Korea Food Research Institute)
Hur, Jinyoung (Korea Food Research Institute)
Hong, Sang Pil (Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Culture / v.35, no.5, 2020 , pp. 467-477 More about this Journal
Abstract
Doenjang is a major fermented soy-based food in Korea. Recent investigations have shown that fermented soybean foods have immunity-enhancing, anti-cancer, anti-obesity and anti-diabetic effects. Several studies also have reported that genistein and daidzein, which are easily absorbed in the body are produced in larger quantities in aged doenjang. The purpose of this study was to evaluate the variations in the anti-cancer effects of commercialized doenjang as it ages. Four groups were formed for this study according to aging periods of doenjang, namely short (under 5 years, S group), mid (under 10 years, M group), long (under 15 years, L group) and very long (over 15 years, E group). The anti-cancer effects of doenjang were determined by cell cytotoxicity assays in A549, YAC-1, and HepG2 cancer cell lines. Also, NK cell activity and splenocyte proliferation were assayed for cancer immunotherapy. The quantities of phenolic compounds in doenjang at different ages were also measured. The results showed that the anti-cancer effects increased in the S and M groups for all three cancer cell lines. Interestingly, similar to this result, splenocyte proliferation and NK activity were also the highest in the S and M groups. In contrast, the E group showed significantly reduced splenocyte proliferation. The quantity of phenolic compounds was similar to that of the anti-cancer results. Collectively, these results suggest that the fermentation period of doenjang plays a very important role in determining its anti-cancer effects.
Keywords
Doenjang; aging period; anti-cancer effect; NK activity; splenocyte;
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Times Cited By KSCI : 9  (Citation Analysis)
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