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http://dx.doi.org/10.7318/KJFC/2012.27.5.535

Brown Rice Phytosterol Improves Hypertension and Lipid Metabolism in Spontaneously Hypertensive Rats  

Hong, Kyung Hee (Department of Food and Nutrition, Baewha Women's University)
Kim, In-Hwan (Department of Food and Nutrition, Korea University)
Choue, Eun Kyung (Division of Metabolism and Functionality Research, Korea Food Research Institute)
Ahn, Jiyun (Division of Metabolism and Functionality Research, Korea Food Research Institute)
Ha, Tae Youl (Division of Metabolism and Functionality Research, Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Culture / v.27, no.5, 2012 , pp. 535-543 More about this Journal
Abstract
This study was conducted to investigate the effects of brown rice and brown rice phytosterol on blood pressure and lipid levels in spontaneously hypertension rats (SHR). SHR were grouped according to blood pressure and fed either a control diet or experimental diets containing 50% brown rice powder or 5% brown rice phytosterol for 3 weeks. Body weight gain and epididymal fat weight were significantly reduced in the brown rice powder and brown rice phytosterol groups compared to control. Brown rice and brown rice phytosterol diets suppressed age-dependent increases in systolic blood pressure compared to control. In addition, brown rice and brown rice phytosterol diets decreased total lipid, triglyceride, and cholesterol levels in the liver, whereas serum HDL cholesterol increased. Lastly, brown rice phytosterol reduced TBARS contents in the kidney. These results suggest that brown rice and brown rice phytosterol exert antihypertensive effects that improve lipid metabolism in SHR.
Keywords
Brown rice; phytosterol; hypotensive effect; lipid profile; spontaneously hypertensive rats;
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1 Ardiansyah, Shirakawa H, Koseki T, Ohinata K, Hashizume K, Komai M. 2006. Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in strokeprone spontaneously hypertensive rats. J Agric Food Chem. 54(5):1914-1920   DOI   ScienceOn
2 Ardiansyah, Shirakawa H, Koseki T, Hashizume K, Komai M. 2007. The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid. Br J Nutr. 97(1):67-76   DOI
3 Baker WL, Baker EL, Coleman CI. 2009. The effect of plant sterols or stanols on lipid parameters in patients with type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. 84(2):e33-37   DOI
4 Bartnick M, Szafranska J. 1987. Change in phatase content and phytase during the germination of some cereals. J Cereal Sci 5:23-28   DOI
5 Billingsley M, Suria A. 1982. Effects of peripherally administered GABA and other amino acids on cardiopulmonary responses in anesthetized rats and dogs. Arch Int Pharmacod 255:131-140
6 Chen CW, Cheng HH. 2006. A rice bran oil diet increases LDLreceptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/ nicotinamide-induced type 2 diabetes. J Nutr. 136(6):1472-1476
7 Choi HD, Kim YS, Choi IW, Park YK, Park YD. 2006. Hypotensive effect of germinated brown rice on spontaneously hypertensive rats. Korean J Food Sci Technol. 38(3):448-451   과학기술학회마을
8 Choi SW, Nam SH, Choi HC. 1996. Antioxidant activit of ethanolic extracts of rice brans. Food Biotechnol 5:305- 309
9 de Jong A, Plat J, Mensink RP 2003. Metabolic effects of plant sterols and stanols. J Nutr Biochem 14:362-369   DOI   ScienceOn
10 Dominiczak AF, Bohr DF. 1995. Nitric oxide and its putative role in hypertension. Hypertension 25(6):1202-1211   DOI
11 Ehlers PI, Kivimäki AS, Turpeinen AM, Korpela R, Vapaatalo H. 2011. High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension. Br J Nutr. 106(9):1353-1363   DOI
12 Hallfrisch J, Scholfield DJ, Behall KM. 2003. Blood pressure reduced by whole grain diet containing barley or whole wheat and brown rice in moderately hyperchoelsterolemic men. Nutr Res 23:1631-1642   DOI
13 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.. 2001. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. Miettinen TA, Gylling H. 2004. Plant stanol and sterol esters in prevention of cardiovascular diseases. Ann Med. 36(2):126-134
14 Folch J, lees M, Sloane GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
15 Fukuda S, Tsuchikura S, Iida H. 2004. Age-related changes in blood pressure, hematological values, concentrations of serum biochemical constituents and weights of organs in the SHR/Izm, SHRSP/Izm and WKY/Izm. Exp Anim. 53(1):67-72   DOI   ScienceOn
16 Hallikainen M, Lyyra-Laitinen T, Laitinen T, Agren JJ, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. 2006. Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. Atherosclerosis. 188(2):425-432   DOI
17 Ha TY, Ko SN, Lee SM, Chung SH, Kim SR, Yoon HH, Kim IH. 2006. Changes in nutraceutical lipid components of rice at different of milling. Eur J Lipid Sci Technol 108:175-181   DOI
18 Hernandez-Ledesma B, Amigo L, Ramos M, Recio I. 2004. Angiotensin converting enzyme inhibitory activity in commercial fermented products. Formation of peptides under simulated gastrointestinal digestion. J Agric Food Chem. 52(6):1504-1510.   DOI   ScienceOn
19 Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M, Sansawa H. 2003. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr. 57(3):490-495   DOI
20 Houston MC. 2005. Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis. 47(6):396-449   DOI
21 Jakala P, Pere E, Lehtinen R, Turpeinen A, Korpela R, Vapaatalo H. 2009. Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats. J Physiol Pharmacol. 60(4):11-20
22 Jones PJ, Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY, Parsons WE. 2000. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res. 41(5):697-705
23 Jung EH, Kim SR, Hwang IK, Ha TY. 2007. Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. J Agric Food Chem. 55(24):9800-9804   DOI   ScienceOn
24 Justo ML, Rodriguez-Rodriguez R, Claro CM, Alvarez de Sotomayor M, Parrado J, Herrera MD. 2012. Watersoluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats. Eur J Nutr. [Epub ahead of print]
25 Kannel WB, Dawber TR, Sorlic P. 1976. components of blood pressure and risk of atherothrombotic brain infarction. Stroke 7:327-331   DOI
26 Kim BH, Sandock KD, Robertson TP, Lewis SJ, Akoh CC. 2008. Dietary structured lipids and phytosteryl esters: blood lipids and cardiovascular status in spontaneously hypertensive rats. Lipids. 43(1):55-64   DOI
27 Koo BS, Lee JW. 2004. Effect of phytosterol treatment on plasma lipids and glucose in rats. Korean J Food Culture 19(4):429-434   과학기술학회마을
28 Lee YR. 2004. Studies of functional foods using giant embryonic rice. Ph. D. degree thesis. Kyungpook National University. pp 159-164
29 Lai MH, Chen YT, Chen YY, Chang JH, Cheng HH. 2012. Effects of rice bran oil on the blood lipids profiles and insulin resistance in type 2 diabetes patients. J Clin Biochem Nutr. 51(1):15-18   DOI
30 Lee MH, Son HS, Choi OK, OH SK, Kwon TB. 1994. Change physicochemical properties and mineral contents during buckwheat germination. Korean J Food Nutr 7:267-273
31 Ling WH, Wang LL, Ma J. 2002. Supplementation of the black rice outer layer fraction to rabbits decreases atherosclerotic plaque formation and increases antioxidant status. J Nutr. 132(1):20-26
32 Miettinen TA, Gylling H. 2004. Plant stanol and sterol esters in prevention of cardiovascular diseases. Ann Med. 36(2):126-134   DOI
33 Miller NE. 1978. The evidence for the antiatherogenicity of high density lipoprotein in man. AOCS Annual Meeting st. Louis, Missouri
34 Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobartituric acid reaction. Anal Biochem 95:35-41
35 Patil GS, Corewell DG. 1978. Intergradical oxidation of ${\alpha}$- tocopherol the surface properties of its oxidation products. J Lipid Res 19:416-422
36 Rhee SJ, Choe WK. 1996. Effects of vitamin E and selenium on the antioxidantative defense system in STZ-induced diabetes rats. Korean J Nutr 29:22-31
37 Rocha M, Banuls C, Bellod L, Jover A, Victor VM, Hernandez-Mijares A. 2011. A review on the role of phytosterols: new insights into cardiovascular risk. Curr Pharm Des. 17(36):4061-4075   DOI
38 Toyokuni S, Itani T, Morimitsu Y, Okada K, Ozeki M, Kondo S, Uchida K, Osawa T, Hiai H, Tashiro T. 2002. Protective effect of colored rice over white rice on Fenton reactionbased renal lipid peroxidation in rats. Free Radic Res. 36(5):583-592   DOI   ScienceOn
39 Suzuki A, Kagawa D, Fujii A, Ochiai R, Tokimitsu I, Saito I. 2002. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens. 15(4 Pt 1):351-357   DOI
40 Sáez GT, Tormos C, Giner V, Chaves J, Lozano JV, Iradi A, Redón J. 2004. Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension. Am J Hypertens. 17(9):809-816   DOI
41 Woyengo TA, Ramprasath VR, Jones PJ. 2009. Anticancer effects of phytosterols. Eur J Clin Nutr. 63(7):813-820   DOI