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http://dx.doi.org/10.7318/KJFC.2008.23.6.812

Effect of Ecklonia cava on the Blood Glucose, Lipids and Renal Oxidative Stress in Diabetic Rats  

Kim, Eun (Major in Food and Nutrition, Mokpo National University)
Kim, Min-Sook (Major in Food and Nutrition, Mokpo National University)
Kim, Se-Youn (Samkwang Medical Laboratories)
Kim, Hyeon-A (Major in Food and Nutrition, Mokpo National University)
Publication Information
Journal of the Korean Society of Food Culture / v.23, no.6, 2008 , pp. 812-819 More about this Journal
Abstract
In this study, we assessed the effects of dietary supplementation with Ecklonia cava on blood glucose, lipid metabolism, and renal oxidative stress in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into a normal rat group fed on a control diet and diabetic rats fed on a control diet or supplemented with powder (15% w/w) or water extract of Ecklonia cava (2.5% w/w). Diabetes was induced by a single injection of STZ (60 mg/kg, ip) in citrate buffer. The animals were fed ad libitum with the experimental diet and water for 5 weeks. Dietary supplementation of Ecklonia cava powder and water extract was shown to reduce blood glucose levels in the diabetic rats, and the water extract was more effective than the powder. Dietary supplementation with Ecklonia cava also reduced LDL cholesterol and increased HDL-cholesterol levels in the diabetic rats. Renal glutathione S-transferase activity was increased in the diabetic rats as compared to the normal rats, but reverted to near control values as the result of dietary supplementation with Ecklonia cava. These results show that Eklonia cava exerts an anti-diabetic effect by improving blood glucose concentrations, LDL/HDL-cholesterol ratios, and antioxidative effects on the kidney in diabetic rats.
Keywords
Ecklonia cava.; Diabetes; Blood glucose; Serum lipid; Renal oxidative stress;
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