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Effects on Hot Water Extract of Schizandra chinensis on Colon Cancer  

Ryu, Min-Ju (Department of Food and Nutrition, Duksung Women's University)
Chung, Ha-Sook (Department of Food and Nutrition, Duksung Women's University)
Publication Information
Food Engineering Progress / v.15, no.1, 2011 , pp. 64-69 More about this Journal
Abstract
The anticancer activity of Schizandra chinensis Baillon was investigated for the development of functional food resources. The antiproliferative activity of hot water extracts of Schizandra chinensis Baillon in human colon cancer cell line (HT-29) were identified using cell viability, morphology study, cell cycle and RT-PCR analyses. HT-29 cells were cultured in several concentrations (0, 1.0, 2.0, 4.0 mg/mL) of water extracts of Schizandra chinensis Baillon. In our study, colon cancer cell growth could be inhibited by hot water extracts of Schizandra chinensis Baillon in a dose-dependent manners. It was associated with morphological changes and apoptotic cell death with cell shrinking, chromatin condensation, apoptotic bodies and cell cycle analysis. These results suggest that Schizandra chinensis Baillon may inhibit the growth of human colon cancer cells by various apoptosis-aiding activities as well as apoptosis itself.
Keywords
Schizandra chinensis Baillon; hot water extraction; freeze drying; colon cancer; apoptosis;
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