Browse > Article
http://dx.doi.org/10.4191/kcers.2015.52.3.204

Effect of Room-temperature, Calcined Eggshell Reactants on Synthesis of Hydroxyapatite  

Kang, Tea-Sung (Department of Advanced Materials Science and Engineering, Mokpo National University)
Pantilimon, Cristian M. (Department of Advanced Materials Science and Engineering, Mokpo National University)
Lee, Sang-Jin (Department of Advanced Materials Science and Engineering, Mokpo National University)
Publication Information
Journal of the Korean Ceramic Society / v.52, no.3, 2015 , pp. 204-208 More about this Journal
Abstract
Synthesis of hydroxyapatite (HA) was attempted through a room-temperature reaction of calcined eggshell with phosphoric acid. Ball-milled, calcined eggshell powder, which has a specific surface area of $31.6m^2/g$, was mixed with various concentrations of phosphoric acid at room temperature. The mixtures showed high reactivity and a vigorous exothermic reaction ; the reacted samples showed both $Ca(OH)_2$ and $CaHPO_4$ crystal phases. After heating at temperatures above $400^{\circ}C$, an HA crystal phase was observed in all samples. The calcined eggshell showed a pure CaO single phase, while the $Ca(OH)_2$ phase was only observed in the wet, ball-milled calcined powder. The degree of formation of the HA crystal phase increased as the phosphoric acid concentration and the heating temperature were increased. A mixture with 50 wt% phosphoric acid concentration showed a well-developed HA crystal phase after heat treatment at $800^{\circ}C$, while the formation of a more intensive amorphous phase was observed in the products of the room-temperature reaction.
Keywords
Biomaterials; Powder processing; Crystallization; X-ray diffraction; Hydroxyapatite;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 T. Kokubo, "Recent Progress in Glass-based Materials for Biomedical Applications," J. Ceram. Soc. Jpn., 99 965-73 (1991).   DOI
2 L. L. Hench, "Bioceramics: from Concept to Clinic," J. Am. Ceram. Soc., 74 1487-510 (1991).   DOI
3 H. M. Kim, "Bioactive Ceramics: Challenges and Perspectives," J. Ceram. Soc. Jpn., 109 49-57 (2001).   DOI
4 C. Ohtsuki, H. Kushitani, T. Kokubo, S. Kotani, and T. Yamamuro, "Apatite Formation on the Surface of Ceravital-type Glass-ceramic in the Body," J. Biomed. Mater. Res., 25 1363-70 (1991).   DOI
5 W. W. Thein-Han and R. D. K. Misra, "Biomimetic Chitosan-Nanohydroxyapatite Composite Scaffolds for Bone Tissue Engineering," Acta Biomater., 5 [4] 1182-97 (2009).   DOI
6 C. Tsioptsias, I. Tsivintzelis, L. Papadopoulou, and C. Panayiotou, "A Novel Method for Producing Tissue Engineering Scaffolds from Chitin, Chitin-Hydroxyapatite, and Cellulose," Mater. Sci. Eng., 29 [1] 159-64 (2009).   DOI
7 S. Koutsopoulos, "Synthesis and Characterization of Hydroxyapatite Crystals: A Review Study on the Analytical Methods," J. Biomed. Mater. Res., 62 [4] 600-12 (2002).   DOI
8 Y. Torrent-Burgues, J. Gomez-Morales, A. Lopez-Macipe, and Y. A. Rodriguez-Clemente, "Continuous Precipitation of Hydroxyapatite from Ca/Citrate/Phosphate Solutions Using Microwave Heating," Cryst. Res. Technol., 34 [5-6] 757-62 (1999).   DOI
9 M. H. Fathi and A. Hanifi, "Evaluation and Characterization of Nanostructure Hydroxyapatite Powder Prepared by Simple Sol-Gel Method," Mater. Lett., 61 [8] 3978-83 (2007).   DOI
10 Z. H. Zhou, P. L. Zhou, S. P. Yang, X. B. Yu, and L. Z. Yang, "Controllable Synthesis of Hydroxyapatite Nano-crystals via a Dendrimer-Assisted Hydrothermal Process," Mater. Res. Bull., 42 [9] 1611-18 (2007).   DOI
11 X. Zhang and K. S. Vecchio, "Hydrothermal Synthesis of Hydroxyapatite Rods," J. Cryst. Growth, 308 [1] 133-40 (2007).   DOI
12 S. Kannan, J. H. G. Rocha, S. Agathopoulos, and J. M. F. Ferreira, "Fluorine Substituted Hydroxyapatite Scaffolds Hydrothermally Grown from Aragonitic Cuttlefish Bones," Acta Biomater., 3 [2] 243-49 (2007).   DOI
13 A. Wang, D. Liu, H. Yin, H. Wu, Y. Wada, M. Ren, T. Jiang, X. Cheng, and Y. Xu, "Size-Controlled Synthesis of Hydroxyapatite Nano-rods by Chemical Precipitation in the Presence of Organic Modifiers," Mater. Sci. Eng., 27[4] 865-69 (2007).   DOI   ScienceOn
14 M. Akao, H. Aoki, and K. Kato, "Mechanical Properties of Sintered Hydroxyapatite for Prosthetic Applications," J. Mater. Sci., 16 809-12 (1981).   DOI
15 A. Banerjee, A. Bandyopadhyay, and S. Bose, "Hydroxyapatite Nano-powders: Synthesis, Densification and Cell-Materials interaction," Mater. Sci. Eng., 27 [4] 729-35 (2007).   DOI   ScienceOn
16 H. Monma, T. Kamiya, M. Tsutsumi, and Y. T. Hasegawa, "Comparative Study on Compaction and Sintering Properties of Hydroxyapatite Powders," Gypsum & Lime, 208 [3] 127-35 (1987).
17 M. Akao, N. Miura, and H. Aoki, "Fracture Toughness of Sintered Hydroxyapatite and Beta-tricalcium Phosphate," J. Ceram. Soc. Jpn., 92 [11] 672-74 (1984).
18 I. J. Macha, L. S. Ozyegin, J. Chou, R. Samur, F. N. Oktar, and B. Ben-Nissan, "An Alternative Synthesis Method for Dicalcium Phosphate (Monetite) Powders from Mediterranean Mussel (Mytilus Glloprovincialis) Shells," J. Aust. Ceram. Soc., 49 [2] 122-28 (2013).
19 H. Onoda, M. Ichimura, and A. Takenaka, "Preparation and Lead Removal Effects of Calcium Phosphates with Sea Urchin Sells," Phosphorus Res. Bull., 24 49-53 (2010).   DOI
20 H. Onoda and H. Nakanishi, "Preparation of Calcium Phosphate with Oyster Shells," Nat. Resources, 3 [2] 71-4 (2012).   DOI
21 M. D. Kwon, S. H. Oh, and S. J. Lee, "Synthesis of ${\beta}$-tricalcium Phosphate by Using an Eggshell," J. Korean Ceram. Soc., 39 [11] 1103-07 (2002).   DOI
22 S. J. Lee, Y. S. Yoon, M. H. Lee, and N. S. Oh, "Highly Sinterable ${\beta}$-tricalcium Phosphate Synthesized from Eggshells," Mater. Lett., 61 1279-82 (2007).   DOI
23 S. J. Lee, Y. C. Lee, and Y. S. Yoon, "Characteristics of Calcium Phosphate Powders Synthesized from Cuttlefish Bone and Phosphoric Acid," J. Ceram. Proc. Res., 8 [6] 427-30 (2007).