Browse > Article
http://dx.doi.org/10.4191/kcers.2011.48.5.390

Fabrication of Hydroxyapatite Ceramics to Mimic the Natural Bone Structure  

Moon, Dae-Hee (Department of Nanomedical Engineering, Pusan National University)
Ryu, Su-Chak (Department of Nanomedical Engineering, Pusan National University)
Publication Information
Journal of the Korean Ceramic Society / v.48, no.5, 2011 , pp. 390-395 More about this Journal
Abstract
The objective of our study was to produce an imitation bone material consisting of hydroxyapatite with a compact and spongy structure. This study shows the ideal content of $SiO_2$ and the sintering temperature to produce imitation bone that has the mechanical properties of natural bone. On the basis of our determination of the ideal conditions, a compact part was produced and its mechanical properties were tested. A compact part made of 0.5 wt% $SiO_2$ and sintered at $1350^{\circ}C$ showed excellent mechanical properties. The bioactivity of the compact part under this condition was tested, and it was found to be bioactive. The porous part was produced by controlling the powder size, and the dual structure was manufactured by combining the compact and porous parts. A water permeability test confirmed that the dual structure had an interconnected pore structure. Therefore, this dual-body structure is feasible for use in the creation of implants.
Keywords
Hydroxyapatite; Dual; Porous; Compact; Implant;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 N. Tamai, A. Myoui, T. Tomita, T. Nakase, J. Tanaka, T. Ochi, and H. Yoshikawa, "Novel Hydroxyapatite Ceramics with an Interconnective Porous Structure Exhibit Superior Osteoconduction in Vivo," J. Biomed. Mater. Res., 59 [1] 110-17 (2002).   DOI
2 M. Sayer, A. D. Stratilatov, J. Reid, L. Calderin, M. J. Stott, X. Yin, M. MacKenzie, T. J. N. Smith, J. A. Hendry, and S. D. Langstaff, "Structure and Composition of Silicon-stabilized Tricalcium Phosphate," Biomaterials, 24 [3] 369-82 (2003).   DOI
3 S. Padilla, J. Rombn, S. Sbnchez-Salcedo, and M. Vallet-Regi, "$Hydroxyapatite/SiO_2-CaO-P_2O_5$ Glass Materials: In Vitro Bioactivity and Biocompatibility," Acta Biomaterialia, 2 [3] 331-42 (2006).   DOI
4 A. Mortier, J. Lemaitre, L. Rodrique, and P. G. Rouxhet, "Synthesis and Thermal Behavior of Well-crystallized Calcium-Deficient Phosphate Apatite," J. Solid State Chem., 78 [2] 215-19 (1989).   DOI
5 R. L. Fullman, "Measurement of Particle Sizes in Opaque Bodies," Trans. Metall. Soc. AIME, 197 447-52 (1953).
6 S. Deb, M. Braden, and W. Bonfield, "Water Absorption Characteristics of Modified Hydroxyapatite Bone Cements," Biomaterials, 16 [14] 1095-100 (1995).   DOI
7 J. Y. Kim, J. W. Lee, S. J. Lee, E. K. Park, S. Y. Kim, and D. W. Cho, "Development of a Bone Scaffold using HA Nanopowder and Micro-stereolithography Technology," Microelectro. Engi., 84 [5-8] 1762-65 (2005).
8 S. C. Ryu, S.-H. Min, and Y.-M. Park, "Mechanical Properties of Hydroxyapatite ${\beta}-TCP$ Composite with Changing $SiO_2$ Contents," Kor. J. Mater. Res., 17 [9] 480-83 (2011).   과학기술학회마을   DOI
9 S. Blindow, M. Pulkin, D. Koch, G. Grathwohl, and K. Rezwan, "$Hydroxyapatite/SiO_2$ Composites via Freeze Casting for Bone Tissue Engineering," Adv. Eng. Mater., 11 [11] 875-84 (2009).   DOI
10 M. O. Dean, "Fabrication of Hydroxyapatite Ceramic with Controlled Porosity," J. Mater. Sci.: Mater. Medicine, 8 [4] 227-32 (1997).   DOI
11 S. H. Kim, B. K. Lim, F. Sun, K. Koh, S. C. Ryu, H. S. Kim, and J. Lee, "Preparation of High Flexible Composite Film of Hydroxyapatite and Chitosan," Polymer Bulletin, 62 [1] 111-8 (2009).   DOI
12 S. C. Ryu, B. K. Lim, F. Sun, K. Koh, D. W. Han, and J. Lee, "Regeneration of a Micro-Scratched Tooth Enamel Layer by Nanoscale Hydroxyapatite Solution," Bull. Kor. Chem. Soc., 30 [1] 887-90 (2009).   과학기술학회마을   DOI
13 B. K. Lim, S. C. Ryu, F. Sun, K. Koh, D. W. Han, and J. Lee, "Hydroxyapatite Coating on Damaged Tooth Surfaces by Immersion," Biomedical Materials, 4 [2] 025017 (2009).   DOI
14 N. Kot, M. Timutin, and F. Korkusuz, "Fabrication and Characterization of Porous Tricalcium Phosphate Ceramics," Ceram. International, 30 [2] 205-11 (2004).   DOI
15 R. A. Ayers, S. J. Simske, C. R. Nunes, and L. M. Wolford, "Long-term Bone Ingrowth and Residual Microhardness of Porous Block Hydroxyapatite Implants in Humans," J. Oral and Maxillofacial Surgery, 56 [11] 1297-301 (1998).   DOI
16 S. R. Levitt, P. H. Crayton, E. A. Monroe, and R. A. Condrate, "Forming Method for Apatite Prostheses," J. Biomed. Mater. Res., 3 [4] 683-84 (1969).   DOI
17 M. Ogiso, "Reassessment of Long-term use of Dense HA as Dental Implant: Case Report," J. Biomed. Mater. Res., 43 [3] 318-20 (1998).   DOI
18 T.-M. G. Chu, D. G. Orton, S. J. Hollister, S. E. Feinberg, and J. W. Halloran, "Mechanical and in Vivo Performance of Hydroxyapatite Implants with Controlled Architectures," Biomaterials, 23 [5] 1283-93 (2002).   DOI
19 L. Le Guehennec, A. Soueidan, P. Layrolle, and Y. Amouriq, "Surface Treatments of Titanium Dental Implants for Rapid Osseointegration," Dental Materials, 23 [7] 844-54 (2007).   DOI
20 M. H. Fathi, M. Salehi, A. Saatchi, V. Mortazavi, and S. B. Moosavi, "In Vitro Corrosion Behavior of Bioceramic, Metallic, and Bioceramic-metallic Coated Stainless Steel Dental Implants," Dental Materials, 19 [3] 188-98 (2003).   DOI
21 J. P. Schmitz, J. O. Hollinger, and S. B. Milam, "Reconstruction of Bone using Calcium Phosphate Bone Cements: A Critical Review," J. Oral and Maxillofacial Surgery, 57 [9] 1122-26 (1999).   DOI
22 Z. Mazor, M. Peleg, A. K. Garg, and G. Chaushu, "The Use of Hydroxyapatite Bone Cement for Sinus Floor Augmentation with Simultaneous Implant Placement in the Atrophic Maxilla. A Report of 10 Cases," J. Periodontology, 71 [7] 1187-94 (2000).   DOI
23 R. B. Martin, "Bone as a Ceramic Composite Material," Materials Science Forum, 293 5-16 (1999).   DOI
24 J. A. Hubbell, "Biomaterials in Tissue Engineering," Nat Biotech, 13 [6] 565-76 (1995).   DOI
25 Langer R and Vacanti JP, "Tissue Engineering," Science, 260 [5110] 920-26 (1993).   DOI
26 W. W. Minuth, M. Sittinger, and S. Kloth, "Tissue Engineering: Generation of Differentiated Artificial Tissues for Biomedical Applications," Cell and Tissue Research, 291 [1] 1-11 (1997).   DOI
27 C. R. Nunes, S. J. Simske, R. Sachdeva, and L. M. Wolford, "Long-term Ingrowth and Apposition of Porous Hydroxylapatite Implants," J. Biomed. Mater. Res., 36 [4] 560-63 (1997).   DOI
28 H. Yoshikawa and A. Myoui,"Bone Tissue Engineering with Porous Hydroxyapatite Ceramics," J. Artificial Organs, 8 [3] 131-36 (2005).   DOI
29 E. A. Monroe, W. Votava, D. B. Bass, and J. M. Mullen, "New Calcium Phosphate Ceramic Material for Bone and Tooth Implants," J. Dental Research, 50 [4] 860-61 (1971).   DOI