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http://dx.doi.org/10.4191/KCERS.2003.40.6.601

Osteoblast Cell Morphology, Proliferation, and Differentiation in Variation with Biomaterials  

김학관 (㈜우리동명 치과재료연구소)
장주웅 (㈜우리동명 치과재료연구소)
정희석 (㈜우리동명 치과재료연구소)
이득용 (대림대학 재료정보공학과)
Publication Information
Journal of the Korean Ceramic Society / v.40, no.6, 2003 , pp. 601-607 More about this Journal
Abstract
Osteoblast-like cell morphology, proliferation, and differentiation were examined in variation with biomaterials. Cells were cultured on TiO$_2$, Ti, 3Y-TZP, HA (Hydroxyapatite) and Thermanox was used as a control specimen. Generally, all specimens have similar cell morphology within the same time interval. However, cells on HA seem to be more thicker than those on TiO$_2$, Ti, 3Y-TZP and cell overlapping was detected very frequently on HA. In case of cell proliferation and differentiation, bioactive material such as HA could help osteoblast-like cell proliferate and provoke a sharp increase of ALP. On the other hand, whether the substrate material is a bioinert ceramics or metal, it does not so strongly affect the cell attachment, proliferation. and differentiation.
Keywords
Osteoblast; Morphology; Proliferation; Differentiation; Bioactive; Bioinert;
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