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http://dx.doi.org/10.11002/kjfp.2017.24.8.1158

Immunomodulatory effects of β-1,3/1,6-glucan and lactic acid bacteria in LP-BM5 murine leukemia viruses-induced murine acquired immune deficiency syndrome  

Kim, Min-Soo (Microbial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, JoongSu (Microbial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Ryu, Min Jung (Department of Cosmetology science, Nambu University)
Kim, Ki hong (Jeonnam Institute for Regional Program Evaluation)
Hwang, Kwontack (Department of Food and Nutrition, Nambu University)
Publication Information
Food Science and Preservation / v.24, no.8, 2017 , pp. 1158-1167 More about this Journal
Abstract
In this study, ${\beta}$-1,3/1,6-glucan, lactic acid bacteria, and ${\beta}$-1,3/1,6-glucan+lactic acid bacteria were tested for 10 weeks using an immunodeficient animal model infected with LP-BM5 murine AIDS virus On the immune activity. Cytokines production, plasma immunoglobulin concentration, T cell and B cell proliferation were measured. As a result, the T cell proliferative capacity which was weakened by immunization with LP-BM5 murine AIDS virus increased significantly T cell proliferative capacity compared with the red ginseng control group. B cell proliferative capacity was significantly higher than the infected control group. Increased B cell proliferation was reduced. In the cytokine production, IL-2, IL-12 and IL-15 in the Th1-type cytokine increased the secretion of IL-2, IL-12 and IL-15 compared to the infected control. The proliferative capacity of the treated group was higher than that of the mixed treatment group. TNF-${\alpha}$ was significantly decreased compared with the infected control group. The IL-4, IL-6 and IL-10 levels were significantly inhibited in the infected control group and the Th1/Th2 type cytokine expression was regulated by immunohistochemistry. IgE, IgA, and IgG levels were significantly lower in the immunoglobulin secretion assay than in the control. As a result, the immunomodulatory effect of ${\beta}$-1,3/1,6-glucan+lactic acid bacteria was confirmed by mixing with LP-BM5 murine AIDS virus-infected immunodeficient animal model.
Keywords
${\beta}$-1,3/1,6-glucan; lactic acid bacteria; immunomodulatory effect; in vivo; cytokines;
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1 Kimura Y, Sumiyoshi M, Suzuki T, Sakanaka, M (2006) Antitumor and antimetastatic activity of a novel water-soluble low molecular weight ${\beta}$-1, 3-D-glucan (branch ${\beta}$-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast. Anticancer Res, 26, 4131-4141
2 Brown GD, Gordon S (2005) Immune recognition of fungal ${\beta}$ glucans. Cell Microbiol, 7, 471-479   DOI
3 Brown GD (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol, 6, 33-43   DOI
4 Lee DH, Kim HW (2014) Innate immunity induced by fungal ${\beta}$-glucans via dectin-1 signaling pathway. Int J Med Mushrooms, 16, 1-16   DOI
5 Brown GD, Taylor PR, Reid DM, Willment JA, Williams, DL, Martinez-Pomares L, Wong SYC, Gordon S (2002) Dectin-1 is a major ${\beta}$-glucan receptor on macrophages. J Exp Med, 196, 407-412   DOI
6 Furrie E (2005) Probiotics and allergy. Proc Nutr Soc, 64, 465-469   DOI
7 Park HS, Lee SH, Uhm TB (1998) Selection of microorganisms for probiotics and their characterization. J Korean Soc Food Sci Nutr, 27, 433-440
8 Rather IA, Bajpai VK, Kumar S, Lim JH, Paek WK, Park YH (2016) Probiotics and Atopic Dermatitis: An Overview. Front Microbiol. 7, 1-7
9 Laiho K, Hoppu U, Ouwehand AC, Salminen S, Isolauri E (2002) Probiotics: on-going research on atopic individuals. Br J Nutr, 88, S19-S27   DOI
10 Kim HJ, Kim YJ, Lee SH, Yu J, Jeong SK, Hong SJ (2014) Effects of Lactobacillus rhamnosus on allergic march model by suppressing Th2, Th17, and TSLP responses via $CD4^{(+)}CD25^{(+)}Foxp3^{(+)}$ Tregs. Clin immunol, 153, 178-186   DOI
11 Odeleye OE, Eskelson CD, Watson RR (1992) Changes in hepatic lipid composition after infection by LP-BM5 murine leukemia virus causing murine AIDS. Life Sci, 51, 129-134   DOI
12 Yoon JY, Hwang KT (2016) An in vitro study of immune activity by ${\beta}$-1,3/1,6-glucan isolated from Aureobasidium pullulans. Korean J Food Preserv, 23, 906-912
13 Lee SJ, Ahn KH, Park CS, Yoon BD, Kim MS (2009) Analysis of ${\beta}$-(1$\rightarrow$3)(1$\rightarrow$6)-glucan produced by Aureobasidium pullulans IMS-822. Korean J Microbiol, 45, 63-68
14 W Oboshi, M Amakawa, R Kato (2014) Effects of ${\beta}$-glucan and lactic acid bacteria on gut immune system. Jap J Med Technol, 63, 673-679
15 Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M, Nabeshima T (2000) Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-${\alpha}$ gene. FASEB J, 14, 1023-1031   DOI
16 Liang B, Wang JY, Watson RR (1996) Murine AIDS, a key to understanding retrovirus-induced immunodeficiency. Viral Immunol, 9, 225-239   DOI
17 Dimitrov DS, Norwood D, Stantchev TS, Feng Y, Xiao X, Broder CC (1999) A mechanism of resistance to HIV-1 entry: inefficient interactions of CXCR4 with CD4 and gp120 in macrophages. Virology, 259, 1-6   DOI
18 Moir S, Buckner CM, Ho J, Wang W, Chen J, Waldner AJ, Posada JG, Kardava L, O'Shea MA, Kottilil S, Chun TW, Proschan MA, Fauci AS (2010) B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood, 116, 5571-5579   DOI
19 Tomasi TB Jr, Tan EM, Solomon A, Prendergast RA (1965) Characteristics of an immune system common to certain external secretions. J Exp Med, 121, 101-124   DOI
20 Gougeon ML, Lecoeur H, Dulioust A, Enouf MG, Crouvoiser M, Goujard C, Debord T, Montagnier L (1996) Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol, 156, 3509-3520
21 Moir S, Malaspina A, Li Y, Chun TW, Lowe T, Adelsberger J, Baseler M, Ehler LA, Liu S, Davey RT Jr, Mican JA, Fauci AS (2000) B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells. J Exp Med, 192, 637-645   DOI
22 Morris L, Binley JM, Clas BA, Bonhoeffer S, Astill TP, Kost R, Hurley A, Cao Y, Markowitz M, Ho DD, Moore JP (1998) HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J Exp Med, 188, 233-245   DOI
23 Meyaard L, Schuitemaker H, Miedema F (1993) T-cell dysfunction in HIV infection: anergy due to defective antigen- presenting cell function? Immunol Today, 14, 161-164   DOI
24 Zimmerli SC, Harari A, Cellerai C, Vallelian F, Bart PA, Pantaleo G (2005) HIV-1-specific IFN-${\gamma}$/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. PNAS, 102, 7239-7244   DOI
25 McIntosh M, Stone BA, Stanisich VA (2005) Curdlan and other bacterial (1$\rightarrow$ 3)-${\beta}$-D-glucans. Appl Microbiol Biotechnol, 68, 163-173   DOI
26 Gonzalez-Rey E, Chorny A, Delgado M (2007) Regulation of immune tolerance by anti-inflammatory neuropeptides. Nat Rev Immunol, 7, 52-63   DOI
27 Kim JS (2001) Mechanism of aging and prevention. Immune Network, 1, 104-108   DOI
28 KHSA (2016) Health functional food market trends and consumer survey. Korea Health Supplements Association. Seongnam, Korea, p 142-144
29 Cui SW, Wang Q (2009) Cell wall polysaccharides in cereals: chemical structures and functional properties. Struct Chem, 20, 291-297   DOI
30 Matse AM, Knott ER, Teunissen PGM, Bartels PV (2000) Effects of high isostatic pressure on mushrooms. J Food Eng, 45, 11-6   DOI