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http://dx.doi.org/10.11002/kjfp.2017.24.8.1122

Inflammation inhibitory effect of water extract from pumpkin's tendril  

Jeong, Ha-Na (Department of and BK21 Plus Program, Chonnam National University)
Choi, Ju-Hee (Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University)
Lee, Ha-Nul (Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University)
Lee, So-Hyeon (Department of and BK21 Plus Program, Chonnam National University)
Cho, Soon-Chang (NaturePureKor)
Park, Jong-Hwan (Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University)
Kim, Young-Min (Department of and BK21 Plus Program, Chonnam National University)
Publication Information
Food Science and Preservation / v.24, no.8, 2017 , pp. 1122-1128 More about this Journal
Abstract
Pumpkin has long been used as traditional health materials in oriental medicine, pharmacy, medicine, and food industries in many countries. In this study, the water extract and two active components from tendril of young C. moschata Duch. were investigated on inflammation inhibitory activity. The water extract of young C. moschata Duch. showed high cell viability over 95% and it decreased the production of interlukin 6 (IL-6) and tumor necrosis factor (TNF-${\alpha}$) in the capacity of mouse bone marrow-derived macrophages (BMDM) upon lipopolysaccharide (LPS) stimulation. Also, isolated fraction (B4) suppressed the secretion of IL-6 and TNF-${\alpha}$. Among the domestically cultivated pumpkins, B4 fraction contained in the tendril part of them and it comprised of the order of tendril from Cucurbita pepo var. cylindrica, old of C. moschata Duch., and young of C. moschata Duch. These results suggest that water extracts of C. moschata Duch. and purified active compound, rutin, show anti-inflammation activity by suppression of the secretion of IL-6 and TNF-${\alpha}$. It can be applicable as pharmaceutical materials.
Keywords
Cucurbita moschata Duch.; tendril; inflammation inhibitory effect; interleukin 6; tumor necrosis factor ${\alpha}$;
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Times Cited By KSCI : 4  (Citation Analysis)
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