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http://dx.doi.org/10.11002/kjfp.2016.23.1.20

Hyaluronidase inhibitory activity of extracted phenolic compounds from ultrafine grind Saururus chinensis  

Park, Ki-Tae (School of Culinary Art and Baking Technology, Dongju College University)
Oh, Sang-Lyong (School of Food Science and Biotechnology / Food and Bio-Industry Research Institute, Kyungpook National University)
Cho, Young-Je (School of Food Science and Biotechnology / Food and Bio-Industry Research Institute, Kyungpook National University)
Publication Information
Food Science and Preservation / v.23, no.1, 2016 , pp. 20-26 More about this Journal
Abstract
In this study, the anti-inflammatory effect of hyaluronidase (HAase) inhibition was determined from 92 species of oriental herbal medicine extracted with water and ethanol solvents because of their non-toxicity in the human body. The water extracts of Evodia officinalis (86.8%), Thuja orientalis (80.8%), Carthami semen (66.5%), Melia azedarach (74.7%), Siegesbeckia pubescens (61.3%), Saururus chinensis (49.15%) showed a relatively greater anti-inflammatory activity. The ethanol extracts of Ailanthus altissima and Saururus chinensis demonstrated the highest anti-inflammatory effect at above 90%. Saururus chinensis was selected for its high anti-inflammatory effect in both water and ethanol extract. Ethanol was more effective than water and optimal extraction conditions for phenolic compounds was determined to be extraction with 50% ethanol for 12 hours. The extracts from Saururus chinensis in optimal condition showed 70~80% anti-inflammatory effect when $100{\sim}250{\mu}g/mL$ phenolic concentration was treated. Concentration of above $500{\mu}g/mL$ decreased the inhibitory effect. The anti-inflammatory effect and extraction yield were increased by ultra-fine grind technology, indicating that this method can be used to increase the extraction yield of phenolic compounds from medicinal plants.
Keywords
anti-inflammatory activity; Saururus chinensis; extracts; phenolic compounds; ultrafine-grinding;
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Times Cited By KSCI : 8  (Citation Analysis)
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