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http://dx.doi.org/10.11002/kjfp.2015.22.1.134

Anti-diabetic effects of Allium tuberosum rottler extracts and lactic acid bacteria fermented extracts in type 2 diabetic mice model  

Kim, Bae Jin (Biohealth Convergence Center, Daegu Technopark)
Jo, Seung Kyeung (Biohealth Convergence Center, Daegu Technopark)
Jeong, Yoo Seok (Biohealth Convergence Center, Daegu Technopark)
Jung, Hee Kyoung (Biohealth Convergence Center, Daegu Technopark)
Publication Information
Food Science and Preservation / v.22, no.1, 2015 , pp. 134-144 More about this Journal
Abstract
The anti-diabetic effects of Allium tuberosum Rottler extracts (ATE) and ATE fermented with lactic acid bacteria in db/db mice were evaluated. The electron donating activity of ATE fermented with Lactobacillus plantarum, and Lactobacillus casei, respectively, increased compared to that of ATE, but the superoxide radical scavenging activity of the ATE incubated with L. plantarum decreased. The superoxide radical scavenging activity of the ATE fermented with both L. plantarum and L. casei was similar to that of the ATE. Therefore, fermented ATE (FATE) was prepared for in vivo testing by incubating it with both L. plantarum and L. casei. The db/db mice were divided into six groups: normal (non-diabetic mice), diabetic control (DM), and four experimental groups administered 200 or 400 mg/kg/day ATE (ATE200 and ATE400) and 200 or 400 mg/kg/day FATE (FATE200 and FATE400). Weight gain was significantly inhibited in the FATE200 group compared with that in the other db/db mice groups (p<0.05). The areas under the curve of the ATE400 and FATE400 groups were significantly smaller than that of the DM group in the glucose tolerance evaluation. The serum glucagon-like peptide-1 levels in the ATE400 and FATE400 groups increased. These results indicate that administering ATE and FATE may be effective against anti-hyperglycemia by regulating insulin resistance. In particular, FATE may be beneficial for controlling obesity in type 2 diabetes.
Keywords
Allium tuberosum rottler; db/db mouse; oral glucose tolerance test; insulin resistance; type 2 diabetes mellitus;
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1 Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL (1998) Overweight and obesity in the United States: prevalence and trends, 1960-1994. J Obes Relat Metab Disord, 22, 39-47   DOI   ScienceOn
2 Korean National Statistical Office (2010) Annual report on the cause of death statistics. 2010. Korean National Statistical Office, Seoul, Korea
3 Guthrie RA, Guthrie DW (2004) Pathophysiology of diabetes mellitus. Crit Care Nurs Q, 27, 113-125   DOI
4 Gonuth SM (1973) Plasma insulin and glucose profiles in normal, obese and diabetic persons. Am Intern Med, 79, 812-822   DOI
5 Semenkovich CF (2006) Insulin resistance and artherosclerosis. J Clin Invest, 116, 1813-1822   DOI
6 Wolff SP, Jiang ZY, Hunt JV (1998) Protein glycation and oxidative stress in diabetic mellitus. Free Radic Biol Med, 10, 339-352
7 Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Lund DD, Yorek MA (2001) Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes, 50, 1927-1937   DOI
8 Lee SZ, Park SH, Lee HS (2001) Change in in vivo lipid peroxidation and antioxidant defecse system in streptozotocin-induced diabetic rats : a time course study. Korean J Nutr, 34, 253-264
9 Bagg W, Plank LD, Gamble G, Drury PL, Sharpe N, Braatvedt GD (2001) The effects of intensive slycemic control on body composition in patients with type 2 diabetes. Diabetes Obes Metab, 3, 410-416   DOI
10 Srinivasan BT, Jarvis J, Khunti K, Davies MJ (2008) Recent advances in the management of type 2 diabetes mellitus : a review. Postgrad Med J, 84, 524-531   DOI
11 Lee SH, Lim SW, Lee YM, Hur JM, Lee HS, Kim DK (2010) Anti-diabetic effects of Triticum aestivum L. water extracts in db/db mice as an animal model of diabetes mellitus type II. Korean J Pharmacogn, 41, 282-288
12 Min OJ Sharma BR, Park CM, Rhyu DY (2011) Effect of Myadis Stigma water extract on adipogenesis and blood glucose in 3T3-L1 adipocytes and db/db mice. Korean J Pharmacogn, 42, 201-208
13 Lee JJ, Kim AR, Chang HC, Jung HO, Lee MY (2012) Effects of soybean and DJI Chungkukjang powder on blood glucose and serum lipid reduction in db/db mice. J Korean Soc Food Sci Nutr, 41, 1086-1093   DOI   ScienceOn
14 Yoo SO, Bae JH (1993) Investigation of Korean native chinese chives on flower bud differentiation. J Korean Soc Hort Sci, 34, 395-401
15 Hubert J, Berger M, Nepveu F, Paul F, Dayd J (2008) Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ. Food Chem, 109, 709-721   DOI
16 Kwak YJ, Jun HJ, Lee MJ, Kwon TW, Kim JS (1998) Modulation of anticarcinogenic enzyme and plasma testosterone level in male mouse fed leek-supplemented diet. J Korean Soc Food Sci Nutr, 27, 968-972
17 Hong JH, Lee MH, Kang MC, Hur SH (2000) Separation and identification of antimicrobial compounds from Korean leek (Allium tuberosum). J Fd Hyg Safety, 15, 235-240
18 Cha JY, Kim SK, Kim HJ, Song JY, Cho YS (2000) Chemical compositions and antioxidative activity of leek (Allium tuberusum) seeds. J Life Sci, 10, 273-278
19 Han SK (2005) Quality improvement of effective microorganisms (EM) pork produced by using EM. J Korean Soc Food Sci Nutr, 34, 734-737   DOI
20 Park JH, Sung KS, Kim SS, shin GS, Han CK (2012) Effects of puffed and fermented red ginseng on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr, 41, 630-637   DOI   ScienceOn
21 Park SJ, Kim KD, Lee JR (2000) Influence of activation temperature of surface and adsorption properties of PAN-based activated carbon fibers/phenolic resin matrix composites. Polym Korea, 24, 97-104
22 Yoon SP, Lee MH, Kim HK, Lee GD (2006) Change in functional properties by extraction condition of roasted Pleurotus eryngii. J Korean Soc Food Sci Nutr, 26, 262-270
23 Parejo I, Viladomat F, Bastida J, Rosas-Romero A, Saavedra G, Muricia MA, Jimenez AM, Colina C (2003) Investigation of Bolivian plant extracts for their radical scavenging activity and antioxidant activity. Life Sci, 73, 1667-1681   DOI
24 Shin DH (1989) A yogurt like product development from rice by lactic acid bacteria. Korean J Food Sci Technol, 21, 686-690
25 Dash DK, Ghosh T, Yeligar VC, Murugesh K, Nayak SS, Maiti BC, Maity TK (2007) Effect of Ichnocarpus frutescens extract on antihyperglycemic, antihyperlipidemic and antioxidant status in streptozotocin-induced diabetic rats. Orient Pharm Exp Med, 7, 244-253   DOI
26 Ko MS, Shin KM, Lee MY (2002) Effects of Hijikia fusifome ethanol extract on antioxidative enzymes in ethanol-induced hepatotoxicity of rat liver. J Korean Soc Food Sci Nutr, 31, 87-91   DOI
27 Pruessner JC, Kirschbaum C, Meinlschmid G, Hellharmmer DH (2003) Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916-931   DOI
28 Lee JS, Lee TS, Noh BS, Park SO (1996) Quality characteristics of mash of Takju prepared by different raw materials. Korean J Food Sci Technol, 28, 330-336
29 Ahn MS, Kim HJ, Seo MS (2005) The antioxidative and antimicrobial activities of the three species of leeks (Allium tuberosun R.) ethanol extracts. Korean J Food Culture, 20, 186-193
30 Jeong YS, Hong JH, Jung HK (2011) Effect of the extracts from Schisandra chinensis fruit and Morus alba leaf on insulin secretion in glucose-induced HIT-T15 Cells. Korean J Food Preserv, 18, 1002-1008   DOI
31 Kwon MJ, Jung HS, Kim MK, Kang SH, Song GW, Song JK, Yoon TY, Jeon MK, Ha TH, Yoon CS, Lee WJ, Noh, JH, Kwon SK, Kim DJ, Koh KS, Rhee BD, Lim KH, Lee SH, Park JH (2007) Cytoprotective effect by antioxidant activity of quercetin in INS-1 cell line. J Korean Diabetes Assoc, 31, 383-390   DOI
32 Yang M, Kwak JS, Jang S, Jia Y, Park IS (2013) Antioxidant activity of soybean yogurt added tomato extract by Bacillus subtilis and Lactobacillus plantarum. Korean J Food Nutr, 26, 280-286   DOI   ScienceOn
33 Kim CH, Kim Ch, Park HK, Suh KI, Lee KU (2002) Effects of antioxidants on ethidium bromide-induced inhibition of insulin secretion in rat pancreatic islets. J Korean Diabetes Assoc, 26, 199-207
34 Seo MY, Lee JK, Ahn BH, Cha SK (2005) The changes of microflora during the fermentation of Takju and Yakju. Korean J Food Sci Technol, 37, 61-66
35 Jang IT, Kim YH, Na KC, Lee JS (2013) Physiological functionality of fermented pear fruitlet product made by mixed fermentation of Saccharomyces cerevisiae, Kluyveromyces fragilis and Lactobacillus plantarum. Korean J Mycol, 41, 33-37   DOI
36 Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med, 334, 292-295   DOI
37 Stivam GP (2001) Protection against Helicobacter pylori and other bacterial infections by garlic. J Nutr, 1321, 1106S-1108S
38 Ahn YM, Lim SJ, Han HK, Choi SS (2006) Effects of Allium vegetable intake on levels of plasma glucose, lipid and minerals in streptozotocin induced diabetic rats. Korean J Nutr, 39, 433-443
39 Kim MJ, Ahn JH, Choi KH, Lee YH, Woo GJ, Hong EK, Chung YS (2006) Effects of pine needle extract oil on blood glucose and serum insulin levels in db/db mice. J Korean Soc Food Sci Nutr, 35, 321-327   DOI
40 Han CK, Kim SS, Choi SY, Park JH. Lee BH (2009) Effects of rice added with mulberry leaves and fruit on blood glucose, body fat and serum lipid levels in rats. J Korean Soc Food Sci Nutr, 38, 1336-1341   DOI
41 Lee YR, Woo KS, Hwang IG, Kim HY, Lee SH, Kim YB, Lee JS, Jeong HS (2012) Anti-diabetic activity of germinated Ilpum rough rice extract supplement in mice. J Korean Soc Food Sci Nutr, 41, 339-344   DOI
42 Stancoven A, McGuire DK (2007) Preventing macrovascular complications in type 2 diabetes mellitus: glucose control and beyond. Am J Cardiol, 99, 5H-11H   DOI
43 Gerich JE (2003) Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med, 163, 1306-1316   DOI
44 Hanefed M, Temelkova-Kurktschiev T (2002) Control of post-prandial and hyperglycemia-an essential part of good diabetes treatment and prevention of cardiovascular complications. Nutr Metab Cardiovasc Dis, 12, 98-107
45 Nathan DM, Singer DE, Godine JE, Harrington CH, Perlmuter LC (1986) Retinopathy in older type II diabetics association with glucose control. Diabetes, 35, 797-801   DOI
46 Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome-a new world-side definition : IDF epidemiology task force consensus group. Lancet, 366, 1059-1062   DOI
47 Despres, JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ (1996) Hyperinsulinemia as an independant risk factor for ischemic heart disease. N Engl J Med, 334, 952-957   DOI
48 Trumper K, Trumper A, Trusheim H, Arnold R, Goke B, Horsch D (2000) Integrative mitogenic role of protein kinase B/Akt in beta-cells. Ann NY Acad Sci, 921, 242-250
49 Seifarth C, Bergmann J, Holst JJ, Ritzel R, Schmiegel W, Nauck MA (1998) Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in type 2 diabetic patients. Diabet Med, 15, 485-491   DOI
50 Sandhu H, Wiesenthal S, MacDonald PE, McCall RH, Tchipashvili V, Rashid S, Satkunarajah M, Irwin DM, Shi ZQ, Brubaker PL, Wheeler MB, Vranic M, Efendic S, Giacca A (1999) Glucagon-like peptide-1 increases insulin sensitivity in depancreatized dogs. Diabetes, 48, 1045-1053   DOI