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http://dx.doi.org/10.11002/kjfp.2011.18.6.998

Inhibitory Effect of Angelica keiskei Extracts on Melanogenesis  

Son, Hyeong-U (Department of Food Science & Biotechnology, Kyungpook National University)
Nam, Dong-Yoon (Department of Food Science & Biotechnology, Kyungpook National University)
Kim, Min-Ah (Department of Food Science & Biotechnology, Kyungpook National University)
Cha, Yong-Su (Department of Food Science & Biotechnology, Kyungpook National University)
Kim, Jong-Myung (Bion Co., Ltd.)
Shin, Yong-Kyu (Bion Co., Ltd.)
Lee, Sang-Han (Department of Food Science & Biotechnology, Kyungpook National University)
Publication Information
Food Science and Preservation / v.18, no.6, 2011 , pp. 998-1001 More about this Journal
Abstract
Angelica keiskei is a perennial herb belonging to the Umbelliferae family. In this study, the whitening effect of A. keiskei extracts was examined through melanogenesis and tyrosinase inhibitory assays. The ethanol extract (50%) significantly inhibited tyrosinase in a concentration-dependent manner. RT-PCR revealed that the extract exhibited decreased expression of tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, and melanocyte-inducing transcription factor. These results suggest that the extract can be used as an ingredient for the development of cosmeceuticals.
Keywords
Angelica keiskei; melanogenesis; tyrosinase; B16F10;
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Times Cited By KSCI : 4  (Citation Analysis)
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