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Effects of Aqueous Medicinal Herb Extracts and Aqueous Fermented Extracts on Alcohol-Metabolizing Enzyme Activities  

Lee, Ka-Soon (Geumsan Ginseng & Medicinal Crop Experiment Station, CNARES.)
Kim, Gwan-Hou (Geumsan Ginseng & Medicinal Crop Experiment Station, CNARES.)
Seong, Bong-Jae (Geumsan Ginseng & Medicinal Crop Experiment Station, CNARES.)
Kim, Hyun-Ho (Geumsan Ginseng & Medicinal Crop Experiment Station, CNARES.)
Kim, Mi-Yeon (Department of Food and Nutrition, Chungnam National University)
Kim, Mee-Ree (Department of Food and Nutrition, Chungnam National University)
Publication Information
Food Science and Preservation / v.16, no.2, 2009 , pp. 259-265 More about this Journal
Abstract
To develop an effective anti-hangover product, hot-water extracts of 25 medicinal herbs were screened for inhibition or activation of alcohol dehydrogenase(ADH) and acetaldehyde dehydrogenase(ALDH), and 12 herbs were selected for further study. Chosen medicinal herb extracts(CMHEs) were fermented by Lactobacillus delbruechii subspecies lactis for 10 days at $35^{\circ}C$ after saccharification with nuruk(malt inoculated by 5 types of microbs) for 72 hours at $35^{\circ}C$ and both CMHEs and fermented CMHEs(FCMHEs) were explored for anti-hangover effects in vitro. We found significant ADH inhibition by hot-water extracts of Pueraria thunbergiana, Hovenia dulcis Thunb, Lycium chinense, Glycyrrhiza uralensis, Acanthopanax sessiliflorus, Liriope platyphylla, and Ixeris dentata, and significant ALDH activation by extracts of Acanthopanax sessiliflorus, Lycium chinense, Ixeris dentata, and Polypori umbellati of the Polyporaceae. The ADH effects on CMHE and FCMHE were -20.22% and -62.63% of control values, and the ALDH effects 173.20% and 280.17%, respectively. In rats given 20%(v/v) alcohol(15 mL/kg), FCMHEs significantly decreased blood acetaldehyde concentrations on 3 hours after ethanol administration, in a dose-dependent manner(p<0.05). Notably, blood acetaldehyde concentrations were markedly reduced in animals given FCMHEs(400 mg/kg) compared to levels seen in rats receiving CADB(commercial alcohol detoxification beverage). Thus, anti-hangover effects were promoted by fermentation of certain medicinal herb extracts.
Keywords
medicinal herbs; hot-water extract; ferment; ADH; ALDH; anti-hangover;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Jerez, S.J. and Coviello, A. (1998) Alcohol drinking and blood pressure among adolescents. Alcohol, 16, 1-5   DOI   ScienceOn
2 Nagaya, T., Yoshida, H., Takahashi, H., Matsuda, Y. and Kawai, M. (1999) Dose-response relationships between drinking and serum tests in Japanese men aged 40~59 years. Alcohol, 17, 133-138   DOI   ScienceOn
3 Lieber C.S. (1995) Medical disorders of alcoholism. New England J. Med., 133, 1058-1065
4 Lieber C.S. (2004) Milestones in liver disease. J. Hepatology, 40, 198-202   DOI   PUBMED   ScienceOn
5 Kweon M.H., Hwang H.J. and Sung H.C. (2001) Identification and antioxidant activity of novel dhlorogenic acid derivatives from bamboo (Phyllostachys edulis). J. Agri. Food Chem., 49, 4646-4655   DOI   ScienceOn
6 Kim C.I. (1999) Cause and effect of hangover. Food Ind. Nutr., 4, 26-30
7 Racker E. (1955) Alcohol dehydrogenase from bakers yeast. Methods of Enzymology, 1, 500-506   DOI
8 Tuskamoto, S., Kanegae, T., Uchigasaki, S., Kitazawa, M., Fusioka, T., Fusioka, S., Imamura, Y., Nagoya, T., Shimamura, M. and Mieda, Y. (1993) Changes in free and bound alcohol metabolites in the urine during ethanol oxidation. Japan J. Alcohol Drug Dependence, 28, 441-452
9 Lieber C.S., Garro A, Leo MA, Mak K.M. and Wornor T. (1986). Alcohol and cancer. Hepatology 6, 1005-1019   DOI   PUBMED
10 Song I, Choi I.S., Yoon H.K. and Koo S.J. (2005) The effect of Camellia sinensis LINNE on alcohol concentration and hangover in normal healthy students. Korean J. Food Cookery Sci., 21, 591-598
11 Yu H.E., Lianiza M.M.D.P., Bae Y.J., Lee D.H., Park J.S., Kwak H.S., Kim H.K. and Lee J.S. (2005) Screening and extraction condition of antiaging bioactive substances from medicinal plants. Korean J. Soc. Food Sci. Nutr., 34, 1136-1142   DOI
12 Xu B.J., Zheng Y.N. and Sung C.K. (2005) Natural medicines for alcoholism treatment: a review. Drug Alcohol Rev., 24, 525-536   DOI   ScienceOn
13 Lieber C.S. (1982) Medical disorders of alcoholism:pathogenesis and treatment. Philadelphia Saunders 53-56
14 Lieber C.S. (1994) Alcohol and liver update. Gastroenterology, 106, 1085-1090   DOI   PUBMED
15 Moon J.S., Kim S.J., Park Y.M., Hwang I.S., Kim E.H., Park J.W., Park I.B., Kim S.W., Kang S.G., Park Y.K. and Jung S.T. (2004) Activities of antioxidation and alcohol dehydrogenase inhibition of methanol extracts from some medicinal herbs. Korean J. Food Preserv., 11, 201-206
16 Hwang J.Y., Ham J.W. and Nam S.H. (2004) Effect of Maesil (Prunus mume) juice on the alcohol metabolizing enzyme activities. Korean J. Food Sci. Technol., 36, 329-332
17 Tottmar S.O., Petterson H. snd Kiessling K.H. (1973) The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. J. Biochem., 135, 577-581   DOI
18 Yu T.S., Choi H.J. and Yoon C.G. (2003) Effect of Monascus pigment extract on the alcohol metabolism in rats. Korean J. Soc. Food Sci. Nutr., 32, 603-607   DOI
19 Kim J.S. (2004) Effect of a alcohol detoxification beverage (ADB) contained Radix puerariae and Banbusae caules in Liquamen Phyllostachyos on the alcohol administered mouse. Korean J. Soci. Food Sci. Nutr., 33, 318-323   DOI
20 McGregor N.R. (2007) Pueraria lobata(Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk. Alcohol, 41, 469-478   DOI   PUBMED   ScienceOn
21 Shumate R.P., Crowther R.F. and Zaraafshan H. (1967) A study of the metabolism rates of alcohol in the human body. J. Forensic Med., 14, 83-100   PUBMED
22 Tuskamoto, S., Muto, T., Nagoya, T., Shimamura, M., Saito, M. and Tainaka, H. (1989) Determination of ethanol, acetaldehyde and acetate in blood and urine during alcohol oxidation in man. Alcohol Alcoholism, 24, 101-108   DOI
23 Lee M.K., Kim Y.G., An S.W., Kim M.H., Lee J.H. and Lee H.Y. (1999) Biological activity of Hovenia dulcis Thunb. Korean J. Med. Crop Sci., 7, 185-192
24 Park E.M., Ye E.J., Kim S.J., Choi H.I. and Bae M.J. (2006) Eliminatory effect of health drink containing Hovenia Dulcis thunb extract on ethanol-induced hangover in rats. Korean J. Food Cult., 21, 71-75
25 Swift R. and Davidson D. (1998) Alcohol hangover, mechanism and mediators. Alcohol Health Res. World, 22, 54-60
26 Lee H.J. and Lee K.M. (1999) Screening of alcohol dehydrogenase inhibitors from natural products. J. Korean Soc. Pharm., 43, 481-486
27 Jo Y.O., Koo S.J., Choi I.S., Kong Y.H. and, Choi S.Y. (2007) Effects of Camellia sinensis extracts on the antioxidant system and alcohol down-regulation enzymes in sub-acute ethanol treated ICR mice. Korean J. Soc. Food Sci. Nutr., 36, 1134-1139   DOI   ScienceOn
28 Choi J.T., Joo H.K. and Lee S.K. (1995) The effect of Schizandrae Fructus extract on alcohol fermentation and enzyme activities of Saccharomyces cerevisiae. Agric. Chem. Biotechnol., 38, 278-282
29 Yang D.S., Hong S.G., Choi S.M., Kim B.N., Sung H.J. and Yoon Y.S. (2004) Effect of an oriental herbal composition, Jang baek union(JBU), on alcohol-induced hangover and CCl4-induced liver injury in rats. Korean J. Soc. Food Sci. Nutr., 33, 78-82   DOI