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Anti-Immunomodulating Activities in Mycelial Filtrates and Culture Broth of Cordyceps ochraceostromat  

Heo, Jin-Chul (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Nam, Sung-Hee (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA)
Lee, Kwang-Gil (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA)
Yeo, Joo-Hong (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA)
Yoon, Chul-Sik (Mycoplus Co., Ltd.)
Park, Chul-Hong (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Nam, So-Hyun (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Son, Min-Sik (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Chung, Shin-Kyo (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Lee, Sang-Han (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
Publication Information
Food Science and Preservation / v.16, no.2, 2009 , pp. 253-258 More about this Journal
Abstract
This study investigated the effects of mycelium and culture supernatant of Cordyceps ochraceostromat(Co) on air way hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of atopy and asthma. After ConA(+/-) activation of mouse primary spleen cells, decreased IL-4 and IL-13 cytokine production were seen in the presence of Co mycelium extracts and culture supernatant. The asthma model involved mice sensitized to ovalbumin by i.p. injection treatment; Co mycelium extract was also injected. The atopy model was the dinitrofenylbenzene-treated mouse ear. Ear thicken ing induced by DNFB was decreased by Co mycelium extract, and the extract also inhibited lung cell infiltration in ovalbumin-induced asthmatic mice. The results thus indicated that the Co mycelial extract reduced the undesirable immune responses seen in asthma and atopy.
Keywords
Cordyceps ochraceostromat; atopy; asthma; airway hyper-responsiveness;
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