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Comparison of Radical Scavenging and Immunomodulatory Activities Exhibited by an Aqueous Extract of Diospyros kaki Thunb. Fruit (Persimmon)  

Heo, Jin-Chul (Department of Food Science & Technology, Kyungpook National University)
Chae, Jang-Heui (Gyeongsangbukdo Agricultural Research & Extension Services)
Lee, Sook-Hee (Gyeongsangbukdo Agricultural Research & Extension Services)
Lee, Yun-Rae (Department of Food Science & Technology, Kyungpook National University)
Moon, Kwang-Deog (Department of Food Science & Technology, Kyungpook National University)
Chung, Shin-Kyo (Department of Food Science & Technology, Kyungpook National University)
Lee, Sang-Han (Department of Food Science & Technology, Kyungpook National University)
Publication Information
Food Science and Preservation / v.15, no.5, 2008 , pp. 749-753 More about this Journal
Abstract
To assess the relationship between anti-oxidant and immunomodulatory activities of Diospyros kaki Thunb. fruit, we harvested persimmons on the first Friday of every month from July to October, and conducted a DPPH assay, a T-bet promoter assay, and an ELISA for IL-4 determination. Anti-oxidant activity increased as fruit weight rose. When the fruit was extracted with five different solvents, and the extracts examined for radical scavenging activity, such activity exhibited a pattern similar to that seen when anti-oxidant activity was assessed. T-bet promoter activity decreased on ripening, whereas IL-4 expression increased, as tested in a DNFB-induced animal model. Collectively, the results suggest that inflammation-inhibitory activity, valuable in treatment of some immune diseases, rises as persimmons ripen.
Keywords
Diospyros kaki Thunb.; anti-oxidant activity; immuno-modulatory activity; T-bet; IL-4;
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Times Cited By KSCI : 5  (Citation Analysis)
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1 Heo, J.C., Woo, S.W., Kweon, M.A., Park, J.Y., Lee, H.K., Son, M., Rho, J.R. and Lee, S.-H. (2008) Aqueous extract of a seed from Helianthus annuus alleviates asthmatic symptoms in vivo. Int. J. Mol. Med., 21, 56-61
2 Park, J.Y., Heo, J.C., An, S.M., Yoon, E.Y., Han, S.M., Hwang, J.S., Kang, S.W., Yun, C.Y., Lee, S.H. (2005) High through-put screening of anti-oxidant activity by medicinal insect libraries. Korean J. Food Preserv., 12, 482-488   과학기술학회마을
3 Woo, K.J., Lee, T.J., Lee, S.H., Jeong, Y.J., Park, J.W., and Kwon, T.K. (2007) Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. Biochem. Pharmacol., 73, 68-76   DOI   ScienceOn
4 Neis, M.M., Peters, B., Dreuw, A., Wenzel, J., Bieber, T., Mauch, C., Krieg, T., Stanzel, S., Heinrich, P.C., Merk, H.F. (2006) Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J. Allergy Clin. Immunol., 118, 930-937   DOI   ScienceOn
5 Finotto, S. (2008) T-cell regulation in asthmatic diseases. Chem. Immunol. Allergy, 94, 83-92   DOI   ScienceOn
6 Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G., Glimcher, L.H. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell, 100, 655-669   DOI   ScienceOn
7 Bellanti, J.A. (1998) Cytokines and allergic diseases: clinical aspects. Allergy Asthma Proc., 9, 337-341
8 Kang, W.W., Kim, K.Y., Kim, J.K., Oh, S.R. (2000) Quality characteristics of the bread added persimmon leaves powder. Korean J. Food Culinary Sci., 16, 336-341   과학기술학회마을
9 Zheng, Q.L., Nakatsuka, A., Itamura, H. (2006) Involvement of negative feedback regulation in wound- induced ethylene synthesis in 'Saijo' persimmon. J. Agric. Food Chem., 54, 5875-5879   DOI   ScienceOn
10 Woo, S.U. Anti-inflammation activities of Diospyros kaki extracts using an atopy-induced animal model and T-bet promoter assay. Feb. 2008. MS thesis, Kyungpook National University, Daegu, Korea.
11 Matsumoto, M., Kotani, M., Fujita, A., Higa, S., Kishimoto, T., Suemura, M., Tanaka, T. (2002) Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br. J. Dermatol., 146, 221-227   DOI   ScienceOn
12 Heo, J.C., Park, J.Y., An, S.M., Lee, J.M., Yun, C.Y., Shin, H.M., Kwon, T.K., Lee, S.H. (2006) Anti-oxidant and anti-tumor activities of Gastrodia elata Blume extracts. Korean J. Food Preserv., 13, 83-87   과학기술학회마을
13 Calcagni, E., Elenkov, I. (2006) Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann. NY Acad. Sci., 1069, 62-76   DOI   ScienceOn
14 Seo, J.H., Jeong, Y.J., Kim, K.S. (2000) Physiological characteristics of tannins isolated from astringent persimmon fruits. Korean J. Food Sci., 32, 212-217   과학기술학회마을
15 Jung, H.S., Jeong, H.S., Lee, J.B., Sung, J.H., Choi, J.U. (2001) Effects of storage conditions on quality change after storage of deastringencied persimmons. Korean J. Food Preserv., 8, 1-8
16 Cha, H.S. (1999) Studies on the Utilization of astringent persimmon. Report of Korea Food Research Institute, pp1-76
17 Hong, J.S., Chae, K.Y. (2005) Physicochemical characteristics and antioxidant activity of astringent persimmon concentrate by boiling. Korean J. Food Culinary Sci., 21, 709-716   과학기술학회마을